TY - JOUR
T1 - MRI-defined subcortical ischemic vascular disease: baseline clinical and neuropsychological findings. The LADIS Study
AU - Jokinen, Hanna
AU - Kalska, Hely
AU - Ylikoski, Raija
AU - Madureira, Sofia
AU - Verdelho, Ana
AU - Gouw, Alida
AU - Scheltens, Philip
AU - Barkhof, Frederik
AU - Visser, Marieke C
AU - Fazekas, Franz
AU - Schmidt, Reinhold
AU - O'Brien, John
AU - Hennerici, Michael
AU - Baezner, Hansjorg
AU - Waldemar, Gunhild
AU - Wallin, Anders
AU - Chabriat, Hugues
AU - Pantoni, Leonardo
AU - Inzitari, Domenico
AU - Erkinjuntti, Timo
AU - LADIS group
N1 - Keywords: Activities of Daily Living; Aged; Aged, 80 and over; Brain; Cognition; Dementia, Vascular; Disability Evaluation; Educational Status; Europe; Female; Humans; Hypertension; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Obesity; Psychomotor Performance
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Subcortical ischemic vascular disease (SIVD) is a common, but often overlooked cause of vascular cognitive impairment. Diagnostic research criteria for SIVD are based on magnetic resonance imaging (MRI) findings including substantial white matter lesions (WML) and multiple lacunar infarcts. Empirical studies validating these imaging criteria are still few. The purpose of the study was to describe the clinical and cognitive characteristics of the MRI-defined SIVD in a mixed sample of functionally independent elderly subjects with WML. METHODS: The subjects of the Leukoaraiosis and Disability (LADIS) study, aged 65-84 years, underwent comprehensive clinical and neuropsychological examinations, and brain MRI at the baseline assessment. The subjects meeting the SIVD imaging criteria (n = 89) were compared to the other subjects of the sample (n = 524). RESULTS: SIVD was associated with lower education, hypertension and, independently, with obesity. The subjects with SIVD had more often motor impairment, a history of falls, and subtle impairment in activities of daily living, but they did not differ for depressive symptoms. SIVD subjects performed significantly inferiorly in tests of global cognitive function, psychomotor speed, attention and executive functions, verbal fluency, and working memory. CONCLUSION: In this population of nondisabled older adults with WML, SIVD was related to specific clinical and functional characteristics. Neuropsychological features included psychomotor slowing as well as deficits in attention and executive functions.
AB - BACKGROUND: Subcortical ischemic vascular disease (SIVD) is a common, but often overlooked cause of vascular cognitive impairment. Diagnostic research criteria for SIVD are based on magnetic resonance imaging (MRI) findings including substantial white matter lesions (WML) and multiple lacunar infarcts. Empirical studies validating these imaging criteria are still few. The purpose of the study was to describe the clinical and cognitive characteristics of the MRI-defined SIVD in a mixed sample of functionally independent elderly subjects with WML. METHODS: The subjects of the Leukoaraiosis and Disability (LADIS) study, aged 65-84 years, underwent comprehensive clinical and neuropsychological examinations, and brain MRI at the baseline assessment. The subjects meeting the SIVD imaging criteria (n = 89) were compared to the other subjects of the sample (n = 524). RESULTS: SIVD was associated with lower education, hypertension and, independently, with obesity. The subjects with SIVD had more often motor impairment, a history of falls, and subtle impairment in activities of daily living, but they did not differ for depressive symptoms. SIVD subjects performed significantly inferiorly in tests of global cognitive function, psychomotor speed, attention and executive functions, verbal fluency, and working memory. CONCLUSION: In this population of nondisabled older adults with WML, SIVD was related to specific clinical and functional characteristics. Neuropsychological features included psychomotor slowing as well as deficits in attention and executive functions.
U2 - 10.1159/000202010
DO - 10.1159/000202010
M3 - Journal article
C2 - 19218799
SN - 1015-9770
VL - 27
SP - 336
EP - 344
JO - Cerebrovascular Diseases
JF - Cerebrovascular Diseases
IS - 4
ER -
