Mosaic maternal ancestry in the Great Lakes region of East Africa

Verónica Gomes; Maria Pala; Antonio Salas; Vanesa Alvarez-Iglesias; António Amorim; Albeto Gómez-Carballa; Ángel Carracedo; Douglas J Clarke; Catherine Hill; Maru Mormina; Marie-Anne Shaw; David W Dunne; Rui Pereira; Vania Pereira; Maria João Prata; Paula Sánchez Diz; Teresa Rito; Pedro Soares; Leonor Gusmão; Martin B Richards

doi:10.1007/s00439-015-1583-0

Mosaic maternal ancestry in the Great Lakes region of East Africa

Verónica Gomes, Maria Pala, Antonio Salas, Vanesa Alvarez-Iglesias, António Amorim, Albeto Gómez-Carballa, Ángel Carracedo, Douglas J Clarke, Catherine Hill, Maru Mormina, Marie-Anne Shaw, David W Dunne, Rui Pereira, Vania Pereira, Maria João Prata, Paula Sánchez Diz, Teresa Rito, Pedro Soares, Leonor Gusmão, Martin B Richards

Afdeling for Retsgenetik

9 Citationer (Scopus)

Abstract

The Great Lakes lie within a region of East Africa with very high human genetic diversity, home of many ethno-linguistic groups usually assumed to be the product of a small number of major dispersals. However, our knowledge of these dispersals relies primarily on the inferences of historical, linguistics and oral traditions, with attempts to match up the archaeological evidence where possible. This is an obvious area to which archaeogenetics can contribute, yet Uganda, at the heart of these developments, has not been studied for mitochondrial DNA (mtDNA) variation. Here, we compare mtDNA lineages at this putative genetic crossroads across 409 representatives of the major language groups: Bantu speakers and Eastern and Western Nilotic speakers. We show that Uganda harbours one of the highest mtDNA diversities within and between linguistic groups, with the various groups significantly differentiated from each other. Despite an inferred linguistic origin in South Sudan, the data from the two Nilotic-speaking groups point to a much more complex history, involving not only possible dispersals from Sudan and the Horn but also large-scale assimilation of autochthonous lineages within East Africa and even Uganda itself. The Eastern Nilotic group also carries signals characteristic of West-Central Africa, primarily due to Bantu influence, whereas a much stronger signal in the Western Nilotic group suggests direct West-Central African ancestry. Bantu speakers share lineages with both Nilotic groups, and also harbour East African lineages not found in Western Nilotic speakers, likely due to assimilating indigenous populations since arriving in the region ~3000 years ago.

Originalsprog	Engelsk
Tidsskrift	Human Genetics
Vol/bind	134
Udgave nummer	9
Sider (fra-til)	1013-1027
ISSN	0340-6717
DOI	https://doi.org/10.1007/s00439-015-1583-0
Status	Udgivet - 10 sep. 2015

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10.1007/s00439-015-1583-0

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Gomes, V., Pala, M., Salas, A., Alvarez-Iglesias, V., Amorim, A., Gómez-Carballa, A., Carracedo, Á., J Clarke, D., Hill, C., Mormina, M., Shaw, M.-A., Dunne, D. W., Pereira, R., Pereira, V., Prata, M. J., Sánchez Diz, P., Rito, T., Soares, P., Gusmão, L., & B Richards, M. (2015). Mosaic maternal ancestry in the Great Lakes region of East Africa. Human Genetics, 134(9), 1013-1027. https://doi.org/10.1007/s00439-015-1583-0

Gomes, V, Pala, M, Salas, A, Alvarez-Iglesias, V, Amorim, A, Gómez-Carballa, A, Carracedo, Á, J Clarke, D, Hill, C, Mormina, M, Shaw, M-A, Dunne, DW, Pereira, R, Pereira, V, Prata, MJ, Sánchez Diz, P, Rito, T, Soares, P, Gusmão, L & B Richards, M 2015, 'Mosaic maternal ancestry in the Great Lakes region of East Africa', Human Genetics, bind 134, nr. 9, s. 1013-1027. https://doi.org/10.1007/s00439-015-1583-0

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abstract = "The Great Lakes lie within a region of East Africa with very high human genetic diversity, home of many ethno-linguistic groups usually assumed to be the product of a small number of major dispersals. However, our knowledge of these dispersals relies primarily on the inferences of historical, linguistics and oral traditions, with attempts to match up the archaeological evidence where possible. This is an obvious area to which archaeogenetics can contribute, yet Uganda, at the heart of these developments, has not been studied for mitochondrial DNA (mtDNA) variation. Here, we compare mtDNA lineages at this putative genetic crossroads across 409 representatives of the major language groups: Bantu speakers and Eastern and Western Nilotic speakers. We show that Uganda harbours one of the highest mtDNA diversities within and between linguistic groups, with the various groups significantly differentiated from each other. Despite an inferred linguistic origin in South Sudan, the data from the two Nilotic-speaking groups point to a much more complex history, involving not only possible dispersals from Sudan and the Horn but also large-scale assimilation of autochthonous lineages within East Africa and even Uganda itself. The Eastern Nilotic group also carries signals characteristic of West-Central Africa, primarily due to Bantu influence, whereas a much stronger signal in the Western Nilotic group suggests direct West-Central African ancestry. Bantu speakers share lineages with both Nilotic groups, and also harbour East African lineages not found in Western Nilotic speakers, likely due to assimilating indigenous populations since arriving in the region ~3000 years ago.",

author = "Ver{\'o}nica Gomes and Maria Pala and Antonio Salas and Vanesa Alvarez-Iglesias and Ant{\'o}nio Amorim and Albeto G{\'o}mez-Carballa and {\'A}ngel Carracedo and {J Clarke}, Douglas and Catherine Hill and Maru Mormina and Marie-Anne Shaw and Dunne, {David W} and Rui Pereira and Vania Pereira and Prata, {Maria Jo{\~a}o} and {S{\'a}nchez Diz}, Paula and Teresa Rito and Pedro Soares and Leonor Gusm{\~a}o and {B Richards}, Martin",

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doi = "10.1007/s00439-015-1583-0",

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AU - Gomes, Verónica

AU - Pala, Maria

AU - Salas, Antonio

AU - Alvarez-Iglesias, Vanesa

AU - Amorim, António

AU - Gómez-Carballa, Albeto

AU - Carracedo, Ángel

AU - J Clarke, Douglas

AU - Hill, Catherine

AU - Mormina, Maru

AU - Shaw, Marie-Anne

AU - Dunne, David W

AU - Pereira, Rui

AU - Pereira, Vania

AU - Prata, Maria João

AU - Sánchez Diz, Paula

AU - Rito, Teresa

AU - Soares, Pedro

AU - Gusmão, Leonor

AU - B Richards, Martin

PY - 2015/9/10

Y1 - 2015/9/10

N2 - The Great Lakes lie within a region of East Africa with very high human genetic diversity, home of many ethno-linguistic groups usually assumed to be the product of a small number of major dispersals. However, our knowledge of these dispersals relies primarily on the inferences of historical, linguistics and oral traditions, with attempts to match up the archaeological evidence where possible. This is an obvious area to which archaeogenetics can contribute, yet Uganda, at the heart of these developments, has not been studied for mitochondrial DNA (mtDNA) variation. Here, we compare mtDNA lineages at this putative genetic crossroads across 409 representatives of the major language groups: Bantu speakers and Eastern and Western Nilotic speakers. We show that Uganda harbours one of the highest mtDNA diversities within and between linguistic groups, with the various groups significantly differentiated from each other. Despite an inferred linguistic origin in South Sudan, the data from the two Nilotic-speaking groups point to a much more complex history, involving not only possible dispersals from Sudan and the Horn but also large-scale assimilation of autochthonous lineages within East Africa and even Uganda itself. The Eastern Nilotic group also carries signals characteristic of West-Central Africa, primarily due to Bantu influence, whereas a much stronger signal in the Western Nilotic group suggests direct West-Central African ancestry. Bantu speakers share lineages with both Nilotic groups, and also harbour East African lineages not found in Western Nilotic speakers, likely due to assimilating indigenous populations since arriving in the region ~3000 years ago.

AB - The Great Lakes lie within a region of East Africa with very high human genetic diversity, home of many ethno-linguistic groups usually assumed to be the product of a small number of major dispersals. However, our knowledge of these dispersals relies primarily on the inferences of historical, linguistics and oral traditions, with attempts to match up the archaeological evidence where possible. This is an obvious area to which archaeogenetics can contribute, yet Uganda, at the heart of these developments, has not been studied for mitochondrial DNA (mtDNA) variation. Here, we compare mtDNA lineages at this putative genetic crossroads across 409 representatives of the major language groups: Bantu speakers and Eastern and Western Nilotic speakers. We show that Uganda harbours one of the highest mtDNA diversities within and between linguistic groups, with the various groups significantly differentiated from each other. Despite an inferred linguistic origin in South Sudan, the data from the two Nilotic-speaking groups point to a much more complex history, involving not only possible dispersals from Sudan and the Horn but also large-scale assimilation of autochthonous lineages within East Africa and even Uganda itself. The Eastern Nilotic group also carries signals characteristic of West-Central Africa, primarily due to Bantu influence, whereas a much stronger signal in the Western Nilotic group suggests direct West-Central African ancestry. Bantu speakers share lineages with both Nilotic groups, and also harbour East African lineages not found in Western Nilotic speakers, likely due to assimilating indigenous populations since arriving in the region ~3000 years ago.

U2 - 10.1007/s00439-015-1583-0

DO - 10.1007/s00439-015-1583-0

M3 - Journal article

C2 - 26188410

SN - 0340-6717

VL - 134

SP - 1013

EP - 1027

JO - Human Genetics

JF - Human Genetics

IS - 9

ER -

Mosaic maternal ancestry in the Great Lakes region of East Africa

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