Morphological evidence of biofilm in chronic obstructive sialadenitis

S. A. Schrøder; S. Eickhardt; T. Bjarnsholt; T. Nørgaard; P. Homøe

doi:10.1017/S0022215118000646

Morphological evidence of biofilm in chronic obstructive sialadenitis

S. A. Schrøder^*, S. Eickhardt, T. Bjarnsholt, T. Nørgaard, P. Homøe

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

7 Citationer (Scopus)

Abstract

Objective Bacterial infection is a common finding in acute sialadenitis and may play a role in the chronicity of the condition. This study investigated if bacterial biofilm is present in submandibular chronic obstructive sialadenitis.Methods A descriptive case-control study was conducted that compared 10 histological sections of submandibular glands with chronic obstructive sialadenitis, to 10 histological sections of the healthy part of submandibular glands with pleomorphic adenoma. Fluorescence in situ hybridisation and confocal laser scanning microscopy visualised evidence of bacterial biofilm.Results In the chronic obstructive sialadenitis group, 5 out of 10 histological sections showed morphological evidence of bacterial biofilm. In the control group, there was no sign of bacterial biofilm formation.Conclusion Morphological evidence of bacterial biofilm was found in the submandibular gland sections from patients with chronic sialadenitis and suggests a role in the chronicity of submandibular chronic obstructive sialadenitis.

Originalsprog	Engelsk
Tidsskrift	Journal of Laryngology and Otology
Vol/bind	132
Udgave nummer	7
Sider (fra-til)	611-614
Antal sider	4
ISSN	0022-2151
DOI	https://doi.org/10.1017/S0022215118000646
Status	Udgivet - 2018

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10.1017/S0022215118000646

Citationsformater

@article{4b91ead3a5454e148bc21721b1341056,

title = "Morphological evidence of biofilm in chronic obstructive sialadenitis",

abstract = "Objective Bacterial infection is a common finding in acute sialadenitis and may play a role in the chronicity of the condition. This study investigated if bacterial biofilm is present in submandibular chronic obstructive sialadenitis.Methods A descriptive case-control study was conducted that compared 10 histological sections of submandibular glands with chronic obstructive sialadenitis, to 10 histological sections of the healthy part of submandibular glands with pleomorphic adenoma. Fluorescence in situ hybridisation and confocal laser scanning microscopy visualised evidence of bacterial biofilm.Results In the chronic obstructive sialadenitis group, 5 out of 10 histological sections showed morphological evidence of bacterial biofilm. In the control group, there was no sign of bacterial biofilm formation.Conclusion Morphological evidence of bacterial biofilm was found in the submandibular gland sections from patients with chronic sialadenitis and suggests a role in the chronicity of submandibular chronic obstructive sialadenitis.",

keywords = "Bacteria, Biofilms, Salivary Gland Calculi, Sialadenitis",

author = "Schr{\o}der, {S. A.} and S. Eickhardt and T. Bjarnsholt and T. N{\o}rgaard and P. Hom{\o}e",

year = "2018",

doi = "10.1017/S0022215118000646",

language = "English",

volume = "132",

pages = "611--614",

journal = "Journal of Laryngology and Otology",

issn = "0022-2151",

publisher = "Cambridge University Press",

number = "7",

}

TY - JOUR

T1 - Morphological evidence of biofilm in chronic obstructive sialadenitis

AU - Schrøder, S. A.

AU - Eickhardt, S.

AU - Bjarnsholt, T.

AU - Nørgaard, T.

AU - Homøe, P.

PY - 2018

Y1 - 2018

N2 - Objective Bacterial infection is a common finding in acute sialadenitis and may play a role in the chronicity of the condition. This study investigated if bacterial biofilm is present in submandibular chronic obstructive sialadenitis.Methods A descriptive case-control study was conducted that compared 10 histological sections of submandibular glands with chronic obstructive sialadenitis, to 10 histological sections of the healthy part of submandibular glands with pleomorphic adenoma. Fluorescence in situ hybridisation and confocal laser scanning microscopy visualised evidence of bacterial biofilm.Results In the chronic obstructive sialadenitis group, 5 out of 10 histological sections showed morphological evidence of bacterial biofilm. In the control group, there was no sign of bacterial biofilm formation.Conclusion Morphological evidence of bacterial biofilm was found in the submandibular gland sections from patients with chronic sialadenitis and suggests a role in the chronicity of submandibular chronic obstructive sialadenitis.

AB - Objective Bacterial infection is a common finding in acute sialadenitis and may play a role in the chronicity of the condition. This study investigated if bacterial biofilm is present in submandibular chronic obstructive sialadenitis.Methods A descriptive case-control study was conducted that compared 10 histological sections of submandibular glands with chronic obstructive sialadenitis, to 10 histological sections of the healthy part of submandibular glands with pleomorphic adenoma. Fluorescence in situ hybridisation and confocal laser scanning microscopy visualised evidence of bacterial biofilm.Results In the chronic obstructive sialadenitis group, 5 out of 10 histological sections showed morphological evidence of bacterial biofilm. In the control group, there was no sign of bacterial biofilm formation.Conclusion Morphological evidence of bacterial biofilm was found in the submandibular gland sections from patients with chronic sialadenitis and suggests a role in the chronicity of submandibular chronic obstructive sialadenitis.

KW - Bacteria

KW - Biofilms

KW - Salivary Gland Calculi

KW - Sialadenitis

U2 - 10.1017/S0022215118000646

DO - 10.1017/S0022215118000646

M3 - Journal article

C2 - 29986787

AN - SCOPUS:85049863656

SN - 0022-2151

VL - 132

SP - 611

EP - 614

JO - Journal of Laryngology and Otology

JF - Journal of Laryngology and Otology

IS - 7

ER -

Morphological evidence of biofilm in chronic obstructive sialadenitis

Abstract

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