TY - JOUR
T1 - Monitoring patients with rheumatoid arthritis in routine care
T2 - experiences from a treat-to-target strategy using the DANBIO registry
AU - Hetland, Merete Lund
AU - Jensen, Dorte Vendelbo
AU - Krogh, Niels Steen
PY - 2014
Y1 - 2014
N2 - Objective. Advances in aggressive use of conventional synthetic diseasemodifying anti-rheumatic drugs (csDMARDs) as well as biological DMARDs (bDMARDs) have improved the treatment armamentarium for rheumatologists, and modern treatment principles include a treat-to-target (T2T) strategy. However, little is known about the feasibility of a T2T strategy in patients with rheumatoid arthritis (RA) treated in routine care. The aim of the present study was to (i) present the annual number of patients included in DANBIO between 2006 and 2013 and their disease characteristics and (ii) estimate coverage of DANBIO by 2013. Methods. Patients who were registered with RA for the first time in the nationwide Danish DANBIO database between year 2006 and 2013 were included. Baseline characteristics were assessed in patients treated with bDMARDs and csDMARDs, respectively. The fraction of patients with low/ moderate/high disease activity (i.e. DAS28 (CRP-based, 4 variables) was calculated for each calendar year. Results. From 2006-2013 the number of patients increased from 2,395 to 14,249. By 2013, 29.8% of patients were receiving bDMARD. Patients in the csDMARD group were older, had shorter disease duration, lower disease activity, less disability and radiographic damage. By 2013, 19% of csDMARD (15% of bDMARD) patients were in ACR/Boolean remission. Coverage had increased to between 41% and 79% for patients with RA, for the bDMARD group it was 94%. Conclusion. Systematic monitoring of RA patients with real-time feedback to the physician is feasible, although the goal of treat-to-target is not achieved in a substantial proportion of patients in routine care.
AB - Objective. Advances in aggressive use of conventional synthetic diseasemodifying anti-rheumatic drugs (csDMARDs) as well as biological DMARDs (bDMARDs) have improved the treatment armamentarium for rheumatologists, and modern treatment principles include a treat-to-target (T2T) strategy. However, little is known about the feasibility of a T2T strategy in patients with rheumatoid arthritis (RA) treated in routine care. The aim of the present study was to (i) present the annual number of patients included in DANBIO between 2006 and 2013 and their disease characteristics and (ii) estimate coverage of DANBIO by 2013. Methods. Patients who were registered with RA for the first time in the nationwide Danish DANBIO database between year 2006 and 2013 were included. Baseline characteristics were assessed in patients treated with bDMARDs and csDMARDs, respectively. The fraction of patients with low/ moderate/high disease activity (i.e. DAS28 (CRP-based, 4 variables) was calculated for each calendar year. Results. From 2006-2013 the number of patients increased from 2,395 to 14,249. By 2013, 29.8% of patients were receiving bDMARD. Patients in the csDMARD group were older, had shorter disease duration, lower disease activity, less disability and radiographic damage. By 2013, 19% of csDMARD (15% of bDMARD) patients were in ACR/Boolean remission. Coverage had increased to between 41% and 79% for patients with RA, for the bDMARD group it was 94%. Conclusion. Systematic monitoring of RA patients with real-time feedback to the physician is feasible, although the goal of treat-to-target is not achieved in a substantial proportion of patients in routine care.
KW - Aged
KW - Antirheumatic Agents
KW - Arthritis, Rheumatoid
KW - Denmark
KW - Disability Evaluation
KW - Disease Progression
KW - Female
KW - Guideline Adherence
KW - Humans
KW - Male
KW - Middle Aged
KW - Outcome and Process Assessment (Health Care)
KW - Physician's Practice Patterns
KW - Practice Guidelines as Topic
KW - Predictive Value of Tests
KW - Registries
KW - Remission Induction
KW - Severity of Illness Index
KW - Standard of Care
KW - Time Factors
KW - Treatment Outcome
M3 - Journal article
C2 - 25365104
SN - 0392-856X
VL - 32
SP - s-141 -s-146
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
IS - Suppl 85
ER -