Molecular Typing of Treponema pallidum in Denmark: A Nationwide Study of Syphilis

Kirsten Salado-Rasmussen; Susan Cowan; Jan Gerstoft; Helle Kiellberg Larsen; Steen Hoffmann; Troels Bygum Knudsen; Terese Lea Katzenstein; Jørgen Skov Jensen

doi:10.2340/00015555-2190

Molecular Typing of Treponema pallidum in Denmark: A Nationwide Study of Syphilis

Kirsten Salado-Rasmussen, Susan Cowan, Jan Gerstoft, Helle Kiellberg Larsen, Steen Hoffmann, Troels Bygum Knudsen, Terese Lea Katzenstein, Jørgen Skov Jensen

Institut for Klinisk Medicin

16 Citationer (Scopus)

Abstract

The aim of this nationwide study is to determine the strain type diversity among patients diagnosed with syphilis by PCR during a 4-year period in Denmark. Epidemiological data, including HIV status, for all patients were obtained from the Danish national syphilis registration system. Molecular strain typing was based on characterization of 3 variable treponemal genes, arp, tpr and tp0548. A total of 278 specimens from 269 patients were included. Among the fully typeable specimens (n = 197), 22 strain types were identified, with 1 type, 14d/g, accounting for 54%. The majority (93%) of the patients reported acquiring syphilis in Denmark. Among patients with concurrent HIV, 9 full strain types were identified and no difference in strain type was found by HIV status (p = 0.197). In conclusion, the majority of patients were infected in Denmark and the HIV-infected syphilis patients were diagnosed with a wide spectrum of different strain types of Treponema pallidum.

Originalsprog	Engelsk
Tidsskrift	Acta Dermatovenereologica
Vol/bind	96
Sider (fra-til)	202-206
Antal sider	5
ISSN	0001-5555
DOI	https://doi.org/10.2340/00015555-2190
Status	Udgivet - feb. 2016

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title = "Molecular Typing of Treponema pallidum in Denmark: A Nationwide Study of Syphilis",

abstract = "The aim of this nationwide study is to determine the strain type diversity among patients diagnosed with syphilis by PCR during a 4-year period in Denmark. Epidemiological data, including HIV status, for all patients were obtained from the Danish national syphilis registration system. Molecular strain typing was based on characterization of 3 variable treponemal genes, arp, tpr and tp0548. A total of 278 specimens from 269 patients were included. Among the fully typeable specimens (n = 197), 22 strain types were identified, with 1 type, 14d/g, accounting for 54%. The majority (93%) of the patients reported acquiring syphilis in Denmark. Among patients with concurrent HIV, 9 full strain types were identified and no difference in strain type was found by HIV status (p = 0.197). In conclusion, the majority of patients were infected in Denmark and the HIV-infected syphilis patients were diagnosed with a wide spectrum of different strain types of Treponema pallidum.",

author = "Kirsten Salado-Rasmussen and Susan Cowan and Jan Gerstoft and Larsen, {Helle Kiellberg} and Steen Hoffmann and Knudsen, {Troels Bygum} and Katzenstein, {Terese Lea} and Jensen, {J{\o}rgen Skov}",

year = "2016",

month = feb,

doi = "10.2340/00015555-2190",

language = "English",

volume = "96",

pages = "202--206",

journal = "Acta Dermato-Venereologica",

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T1 - Molecular Typing of Treponema pallidum in Denmark

T2 - A Nationwide Study of Syphilis

AU - Salado-Rasmussen, Kirsten

AU - Cowan, Susan

AU - Gerstoft, Jan

AU - Larsen, Helle Kiellberg

AU - Hoffmann, Steen

AU - Knudsen, Troels Bygum

AU - Katzenstein, Terese Lea

AU - Jensen, Jørgen Skov

PY - 2016/2

Y1 - 2016/2

N2 - The aim of this nationwide study is to determine the strain type diversity among patients diagnosed with syphilis by PCR during a 4-year period in Denmark. Epidemiological data, including HIV status, for all patients were obtained from the Danish national syphilis registration system. Molecular strain typing was based on characterization of 3 variable treponemal genes, arp, tpr and tp0548. A total of 278 specimens from 269 patients were included. Among the fully typeable specimens (n = 197), 22 strain types were identified, with 1 type, 14d/g, accounting for 54%. The majority (93%) of the patients reported acquiring syphilis in Denmark. Among patients with concurrent HIV, 9 full strain types were identified and no difference in strain type was found by HIV status (p = 0.197). In conclusion, the majority of patients were infected in Denmark and the HIV-infected syphilis patients were diagnosed with a wide spectrum of different strain types of Treponema pallidum.

AB - The aim of this nationwide study is to determine the strain type diversity among patients diagnosed with syphilis by PCR during a 4-year period in Denmark. Epidemiological data, including HIV status, for all patients were obtained from the Danish national syphilis registration system. Molecular strain typing was based on characterization of 3 variable treponemal genes, arp, tpr and tp0548. A total of 278 specimens from 269 patients were included. Among the fully typeable specimens (n = 197), 22 strain types were identified, with 1 type, 14d/g, accounting for 54%. The majority (93%) of the patients reported acquiring syphilis in Denmark. Among patients with concurrent HIV, 9 full strain types were identified and no difference in strain type was found by HIV status (p = 0.197). In conclusion, the majority of patients were infected in Denmark and the HIV-infected syphilis patients were diagnosed with a wide spectrum of different strain types of Treponema pallidum.

U2 - 10.2340/00015555-2190

DO - 10.2340/00015555-2190

M3 - Journal article

C2 - 26122912

SN - 0001-5555

VL - 96

SP - 202

EP - 206

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

ER -

Molecular Typing of Treponema pallidum in Denmark: A Nationwide Study of Syphilis

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