Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: Identification of deregulated genes of significance for inflammation and immune surveillance

TY - JOUR

T1 - Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms

T2 - Identification of deregulated genes of significance for inflammation and immune surveillance

AU - Skov, V.

AU - Thomassen, Mads

AU - Kruse, T.A.

AU - Larsen, T.S.

AU - Riley, C.H.

AU - Jensen, Morten Steen Kvistholm

AU - Bjerrum, O.W.

AU - Hasselbalch, H.C.

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) are hematopoietic stem cell neoplasms that may be associated with autoimmune or chronic inflammatory disorders. Earlier gene expression profiling studies have demonstrated aberrant expression of genes involved in inflammatory responses, mainly being performed on granulocytes or CD34+ cells. Using gene expression profiling of whole blood from patients with ET (n=16), PV (n=36), and PMF (n=9), several genes involved in inflammation and immune regulation were found to be significantly deregulated. Our findings may reflect chronic inflammation to be of pathogenetic importance for the progression of these neoplasms toward the myelofibrotic end-stage and may also account for the increased frequency of second cancer in these diseases.

AB - Essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) are hematopoietic stem cell neoplasms that may be associated with autoimmune or chronic inflammatory disorders. Earlier gene expression profiling studies have demonstrated aberrant expression of genes involved in inflammatory responses, mainly being performed on granulocytes or CD34+ cells. Using gene expression profiling of whole blood from patients with ET (n=16), PV (n=36), and PMF (n=9), several genes involved in inflammation and immune regulation were found to be significantly deregulated. Our findings may reflect chronic inflammation to be of pathogenetic importance for the progression of these neoplasms toward the myelofibrotic end-stage and may also account for the increased frequency of second cancer in these diseases.

UR - http://www.scopus.com/inward/record.url?scp=84866332049&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2012.07.009

DO - 10.1016/j.leukres.2012.07.009

M3 - Journal article

C2 - 22877729

AN - SCOPUS:84866332049

SN - 0145-2126

VL - 36

SP - 1387

EP - 1392

JO - Leukemia Research

JF - Leukemia Research

IS - 11

ER -