Molecular Pharmacology of CXCR4 inhibition

TY - CHAP

T1 - Molecular Pharmacology of CXCR4 inhibition

AU - Steen, Anne

AU - Rosenkilde, Mette Marie

PY - 2012/1/1

Y1 - 2012/1/1

N2 - In recent years, the chemokine receptor CXCR4 has been shown to beimplemented in the mobilization of progenitor cells from the bone marrow. Thisfinding has prompted a search for CXCR4 antagonists acting as stem cell mobilizingagents. In accordance, it is important to look into the molecular pharmacologyof well-known CXCR4 antagonists in order to augment the potency and affinity andto increase the specificity of future CXCR4-targeting compounds. In this chapter,binding modes of CXCR4 antagonists that have been shown to mobilize stem cellsare discussed. In addition, comparisons between results obtained from structure–function studies and findings from newly released crystal structures are drawn.

AB - In recent years, the chemokine receptor CXCR4 has been shown to beimplemented in the mobilization of progenitor cells from the bone marrow. Thisfinding has prompted a search for CXCR4 antagonists acting as stem cell mobilizingagents. In accordance, it is important to look into the molecular pharmacologyof well-known CXCR4 antagonists in order to augment the potency and affinity andto increase the specificity of future CXCR4-targeting compounds. In this chapter,binding modes of CXCR4 antagonists that have been shown to mobilize stem cellsare discussed. In addition, comparisons between results obtained from structure–function studies and findings from newly released crystal structures are drawn.

U2 - 10.1007/978-1-4614-1960-0_2

DO - 10.1007/978-1-4614-1960-0_2

M3 - Book chapter

SN - 978-1-4614-1959-4

SP - 23

EP - 35

BT - Novel Developments in Stem Cell Mobilization

A2 - Fruehauf, Stefan

A2 - Zeller, Jens W.

A2 - Calandra, Gary

PB - Springer Science+Business Media

ER -