Molecular Perturbations in Cholangiocarcinoma: Is it Time for Precision Medicine?

TY - JOUR

T1 - Molecular Perturbations in Cholangiocarcinoma

T2 - Is it Time for Precision Medicine?

AU - Braconi, Chiara

AU - Roessler, Stephanie

AU - Kruk, Beata

AU - Lammert, Frank

AU - Krawczyk, Marcin

AU - Andersen, Jesper B

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/5

Y1 - 2019/5

N2 - The complexity of cholangiocarcinoma (CCA) cellularity and the molecular perturbation mechanisms that underlie the diversity of growth patterns of this malignancy remain a clinical concern. Tumours of the biliary system display significant intrinsic chemoresistance, caused by significant stromal involvement and genome–wide tumour heterogeneity, hampering disease remission and palliation as well as promoting the metastatic behaviour. It is crucial to advance our present understanding of the risk and molecular pathogenesis of CCA. This will facilitate the delineation of patient subsets based on molecular perturbations and adjust for precision therapies.

AB - The complexity of cholangiocarcinoma (CCA) cellularity and the molecular perturbation mechanisms that underlie the diversity of growth patterns of this malignancy remain a clinical concern. Tumours of the biliary system display significant intrinsic chemoresistance, caused by significant stromal involvement and genome–wide tumour heterogeneity, hampering disease remission and palliation as well as promoting the metastatic behaviour. It is crucial to advance our present understanding of the risk and molecular pathogenesis of CCA. This will facilitate the delineation of patient subsets based on molecular perturbations and adjust for precision therapies.

U2 - 10.1111/liv.14085

DO - 10.1111/liv.14085

M3 - Review

C2 - 30829432

SN - 1478-3223

VL - 39

SP - 32

EP - 42

JO - Liver International

JF - Liver International

IS - Suppl. 1

ER -