Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment

TY - JOUR

T1 - Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment

AU - Hojman, Pernille

AU - Gehl, Julie

AU - Christensen, Jesper F.

AU - Pedersen, Bente K.

PY - 2018/1/9

Y1 - 2018/1/9

N2 - The benefits of exercise training for cancer patients are becoming increasingly evident. Physical exercise has been shown to reduce cancer incidence and inhibit tumor growth. Here we provide the status of the current molecular understanding of the effect of exercise on cancer. We propose that exercise has a role in controlling cancer progression through a direct effect on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of anti-cancer treatment efficacy. These findings have wide-ranging societal implications, as this understanding may lead to changes in cancer treatment strategies. Hojman et al. discuss the role of exercise in controlling cancer progression through direct effects on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of cancer treatment efficacy. Understanding these mechanistic interactions is warranted for pursuing exercise as cancer medicine.

AB - The benefits of exercise training for cancer patients are becoming increasingly evident. Physical exercise has been shown to reduce cancer incidence and inhibit tumor growth. Here we provide the status of the current molecular understanding of the effect of exercise on cancer. We propose that exercise has a role in controlling cancer progression through a direct effect on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of anti-cancer treatment efficacy. These findings have wide-ranging societal implications, as this understanding may lead to changes in cancer treatment strategies. Hojman et al. discuss the role of exercise in controlling cancer progression through direct effects on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of cancer treatment efficacy. Understanding these mechanistic interactions is warranted for pursuing exercise as cancer medicine.

KW - Biomarkers

KW - Cancer

KW - Cancer therapy

KW - Cancer-related depression

KW - Epinephrine

KW - Exercise training

KW - Immune surveillance

KW - Physical activity

KW - Tumor

KW - Tumor microenvironment

U2 - 10.1016/j.cmet.2017.09.015

DO - 10.1016/j.cmet.2017.09.015

M3 - Review

C2 - 29056514

AN - SCOPUS:85031826765

SN - 1550-4131

VL - 27

SP - 10

EP - 21

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -