Molecular characterization of the Himalayan mink

Bernhard F. Benkel; Kirsti Rouvinen-Watt; Hossain Farid; Razvan Marian Anistoroaei

doi:10.1007/s00335-009-9177-6

Molecular characterization of the Himalayan mink

Bernhard F. Benkel, Kirsti Rouvinen-Watt, Hossain Farid, Razvan Marian Anistoroaei

15 Citationer (Scopus)

Abstract

A rare color variant of the American mink (Neovison vison), discovered on a ranch in Nova Scotia and referred to as the "marbled" variety, carries a distinctive pigment distribution pattern resembling that found in some other species, e.g., the Siamese cat and the Himalayan mouse. We tested the hypothesis that the color pattern in question-light-colored body with dark-colored points (ears, face, tail, and feet)-is due to a mutation in the melanin-producing enzyme tyrosinase (TYR) that results in temperature-sensitive pigment production. Our study shows that marbled mink carry a mutation in exon 4 of the TYR gene (c.1835C > G) which results in an amino acid substitution (p.H420Q). The location of this substitution corresponds to the amino acid position that is also mutated in the TYR protein of the Himalayan mouse. Thus, the marbled variant is more aptly referred to as the Himalayan mink.

Originalsprog	Engelsk
Tidsskrift	Mammalian Genome
Vol/bind	20
Udgave nummer	4
Sider (fra-til)	256-259
Antal sider	4
ISSN	0938-8990
DOI	https://doi.org/10.1007/s00335-009-9177-6
Status	Udgivet - 2009

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10.1007/s00335-009-9177-6

Citationsformater

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title = "Molecular characterization of the Himalayan mink",

abstract = "A rare color variant of the American mink (Neovison vison), discovered on a ranch in Nova Scotia and referred to as the {"}marbled{"} variety, carries a distinctive pigment distribution pattern resembling that found in some other species, e.g., the Siamese cat and the Himalayan mouse. We tested the hypothesis that the color pattern in question-light-colored body with dark-colored points (ears, face, tail, and feet)-is due to a mutation in the melanin-producing enzyme tyrosinase (TYR) that results in temperature-sensitive pigment production. Our study shows that marbled mink carry a mutation in exon 4 of the TYR gene (c.1835C > G) which results in an amino acid substitution (p.H420Q). The location of this substitution corresponds to the amino acid position that is also mutated in the TYR protein of the Himalayan mouse. Thus, the marbled variant is more aptly referred to as the Himalayan mink.",

author = "Benkel, {Bernhard F.} and Kirsti Rouvinen-Watt and Hossain Farid and Anistoroaei, {Razvan Marian}",

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T1 - Molecular characterization of the Himalayan mink

AU - Benkel, Bernhard F.

AU - Rouvinen-Watt, Kirsti

AU - Farid, Hossain

AU - Anistoroaei, Razvan Marian

PY - 2009

Y1 - 2009

N2 - A rare color variant of the American mink (Neovison vison), discovered on a ranch in Nova Scotia and referred to as the "marbled" variety, carries a distinctive pigment distribution pattern resembling that found in some other species, e.g., the Siamese cat and the Himalayan mouse. We tested the hypothesis that the color pattern in question-light-colored body with dark-colored points (ears, face, tail, and feet)-is due to a mutation in the melanin-producing enzyme tyrosinase (TYR) that results in temperature-sensitive pigment production. Our study shows that marbled mink carry a mutation in exon 4 of the TYR gene (c.1835C > G) which results in an amino acid substitution (p.H420Q). The location of this substitution corresponds to the amino acid position that is also mutated in the TYR protein of the Himalayan mouse. Thus, the marbled variant is more aptly referred to as the Himalayan mink.

AB - A rare color variant of the American mink (Neovison vison), discovered on a ranch in Nova Scotia and referred to as the "marbled" variety, carries a distinctive pigment distribution pattern resembling that found in some other species, e.g., the Siamese cat and the Himalayan mouse. We tested the hypothesis that the color pattern in question-light-colored body with dark-colored points (ears, face, tail, and feet)-is due to a mutation in the melanin-producing enzyme tyrosinase (TYR) that results in temperature-sensitive pigment production. Our study shows that marbled mink carry a mutation in exon 4 of the TYR gene (c.1835C > G) which results in an amino acid substitution (p.H420Q). The location of this substitution corresponds to the amino acid position that is also mutated in the TYR protein of the Himalayan mouse. Thus, the marbled variant is more aptly referred to as the Himalayan mink.

U2 - 10.1007/s00335-009-9177-6

DO - 10.1007/s00335-009-9177-6

M3 - Journal article

C2 - 19308642

SN - 0938-8990

VL - 20

SP - 256

EP - 259

JO - Mammalian Genome

JF - Mammalian Genome

IS - 4

ER -

Molecular characterization of the Himalayan mink

Abstract

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