@article{ef7f65805ca011dea8de000ea68e967b,
title = "Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by small changes in cell volume",
abstract = "The K+ channels Kir4.1 and Kir4.1-Kir5.1 are expressed in the glial cells of the CNS and are involved in regulation of the K+ homeostasis. Several studies have shown that Kir4.1 channels are co-localized with aquaporins (AQP4) in the glial endfeet, and a putative functional coupling between the Kir channels and aquaporins is therefore debated. To test a possible volume-sensitivity of the Kir channels, the Kir4.1 or Kir4.1-Kir5.1 channels were expressed in Xenopus oocytes with or without co-expression of aquaporins and subsequently exposed to cell volume alterations. Our results show an increase in Kir4.1 and Kir4.1-Kir5.1 currents upon swelling of the oocytes and a reduction in the current when the oocytes were shrunk. The volume-dependent changes in channel activity were not due to changes in the kinetics of the channels. These findings implicate a putative functional interaction between the Kir channels and aquaporins via small, fast cell volume changes in the glial cells.",
author = "Rikke Soe and Nanna Macaulay and Klaerke, {Dan Arne}",
year = "2009",
month = jun,
doi = "10.1016/j.neulet.2009.04.010",
language = "English",
volume = "457",
pages = "80--4",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",
}