Modulation of anxiety circuits by serotonergic systems

Christopher A Lowry; Philip L Johnson; Anders Hay-Schmidt; Jens Mikkelsen; Anantha Shekhar

doi:10.1080/10253890500492787

Modulation of anxiety circuits by serotonergic systems

Christopher A Lowry, Philip L Johnson, Anders Hay-Schmidt, Jens Mikkelsen, Anantha Shekhar

Eyepath Lab

222 Citationer (Scopus)

Abstract

Anxiety is a complex emotional state associated with sustained heightened autonomic and behavioral arousal and an increase in avoidance behavior. Anxiety-related behavior is a form of risk assessment behavior that is associated with a level of uncertainty or unpredictability regarding the outcome of emotionally salient events, often when both rewarding and aversive outcomes are possible. In this review, we highlight recent advances in our understanding of the neural circuits regulating anxiety states and anxiety-related behavior with an emphasis on the role of brainstem serotonergic systems in modulating anxiety-related circuits. In particular, we explore the possibility that the regulation of anxiety states and anxiety-related behavior by serotonergic systems is dependent on a specific, topographically organized mesolimbocortical serotonergic system that originates in the mid-rostrocaudal and caudal parts of the dorsal raphe nucleus.

Originalsprog	Engelsk
Tidsskrift	Stress: The International Journal on the Biology of Stress
Vol/bind	8
Udgave nummer	4
Sider (fra-til)	233-246
Antal sider	14
ISSN	1025-3890
DOI	https://doi.org/10.1080/10253890500492787
Status	Udgivet - dec. 2005

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10.1080/10253890500492787

Citationsformater

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title = "Modulation of anxiety circuits by serotonergic systems",

abstract = "Anxiety is a complex emotional state associated with sustained heightened autonomic and behavioral arousal and an increase in avoidance behavior. Anxiety-related behavior is a form of risk assessment behavior that is associated with a level of uncertainty or unpredictability regarding the outcome of emotionally salient events, often when both rewarding and aversive outcomes are possible. In this review, we highlight recent advances in our understanding of the neural circuits regulating anxiety states and anxiety-related behavior with an emphasis on the role of brainstem serotonergic systems in modulating anxiety-related circuits. In particular, we explore the possibility that the regulation of anxiety states and anxiety-related behavior by serotonergic systems is dependent on a specific, topographically organized mesolimbocortical serotonergic system that originates in the mid-rostrocaudal and caudal parts of the dorsal raphe nucleus.",

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AU - Lowry, Christopher A

AU - Johnson, Philip L

AU - Hay-Schmidt, Anders

AU - Mikkelsen, Jens

AU - Shekhar, Anantha

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Y1 - 2005/12

N2 - Anxiety is a complex emotional state associated with sustained heightened autonomic and behavioral arousal and an increase in avoidance behavior. Anxiety-related behavior is a form of risk assessment behavior that is associated with a level of uncertainty or unpredictability regarding the outcome of emotionally salient events, often when both rewarding and aversive outcomes are possible. In this review, we highlight recent advances in our understanding of the neural circuits regulating anxiety states and anxiety-related behavior with an emphasis on the role of brainstem serotonergic systems in modulating anxiety-related circuits. In particular, we explore the possibility that the regulation of anxiety states and anxiety-related behavior by serotonergic systems is dependent on a specific, topographically organized mesolimbocortical serotonergic system that originates in the mid-rostrocaudal and caudal parts of the dorsal raphe nucleus.

AB - Anxiety is a complex emotional state associated with sustained heightened autonomic and behavioral arousal and an increase in avoidance behavior. Anxiety-related behavior is a form of risk assessment behavior that is associated with a level of uncertainty or unpredictability regarding the outcome of emotionally salient events, often when both rewarding and aversive outcomes are possible. In this review, we highlight recent advances in our understanding of the neural circuits regulating anxiety states and anxiety-related behavior with an emphasis on the role of brainstem serotonergic systems in modulating anxiety-related circuits. In particular, we explore the possibility that the regulation of anxiety states and anxiety-related behavior by serotonergic systems is dependent on a specific, topographically organized mesolimbocortical serotonergic system that originates in the mid-rostrocaudal and caudal parts of the dorsal raphe nucleus.

KW - Amygdala

KW - Animals

KW - Anxiety

KW - Brain Mapping

KW - Disease Models, Animal

KW - Mental Disorders

KW - Models, Biological

KW - Neurons

KW - Rats

KW - Rats, Wistar

KW - Serotonin

KW - Serotonin Agents

KW - Serotonin Antagonists

KW - Serotonin Receptor Agonists

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DO - 10.1080/10253890500492787

M3 - Journal article

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JO - Stress: The International Journal on the Biology of Stress

JF - Stress: The International Journal on the Biology of Stress

IS - 4

ER -

Modulation of anxiety circuits by serotonergic systems

Abstract

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