@article{22c06aa01bcf11df8ed1000ea68e967b,
title = "Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities",
abstract = "Methods for selective alkylation of chalcones in the alpha- or beta-position and for selective reduction of the alpha,beta-double bond have been developed. The antiparasitic potencies of the alpha,beta-double bond modified chalcones only differ marginally from the potencies of the parent chalcones indicating that the propenone residue only functions as a spacer between the two benzene rings, which are the true pharmacophore.",
author = "Nielsen, {S F} and A Kharazmi and Christensen, {S B}",
note = "Keywords: Animals; Antimalarials; Chalcone; Erythrocytes; Leishmania major; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents",
year = "1998",
language = "English",
volume = "6",
pages = "937--45",
journal = "Bioorganic & Medicinal Chemistry",
issn = "0968-0896",
publisher = "Pergamon Press",
number = "7",
}