TY - JOUR
T1 - Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid
AU - Malle, Ernst
AU - Marsche, Gunther
AU - Arnhold, Jürgen
AU - Davies, Michael Jonathan
PY - 2006/4
Y1 - 2006/4
N2 - Substantial evidence supports the notion that oxidative processes contribute to the pathogenesis of atherosclerosis and coronary heart disease. The nature of the oxidants that give rise to the elevated levels of oxidised lipids and proteins, and decreased levels of antioxidants, detected in human atherosclerotic lesions are, however, unclear, with multiple species having been invoked. Over the last few years, considerable data have been obtained in support of the hypothesis that oxidants generated by the heme enzyme myeloperoxidase play a key role in oxidation reactions in the artery wall. In this article, the evidence for a role of myeloperoxidase, and oxidants generated therefrom, in the modification of low-density lipoprotein, the major source of lipids in atherosclerotic lesions, is reviewed. Particular emphasis is placed on the reactions of the reactive species generated by this enzyme, the mechanisms and sites of damage, the role of modification of the different components of low-density lipoprotein, and the biological consequences of such oxidation on cell types present in the artery wall and in the circulation, respectively.
AB - Substantial evidence supports the notion that oxidative processes contribute to the pathogenesis of atherosclerosis and coronary heart disease. The nature of the oxidants that give rise to the elevated levels of oxidised lipids and proteins, and decreased levels of antioxidants, detected in human atherosclerotic lesions are, however, unclear, with multiple species having been invoked. Over the last few years, considerable data have been obtained in support of the hypothesis that oxidants generated by the heme enzyme myeloperoxidase play a key role in oxidation reactions in the artery wall. In this article, the evidence for a role of myeloperoxidase, and oxidants generated therefrom, in the modification of low-density lipoprotein, the major source of lipids in atherosclerotic lesions, is reviewed. Particular emphasis is placed on the reactions of the reactive species generated by this enzyme, the mechanisms and sites of damage, the role of modification of the different components of low-density lipoprotein, and the biological consequences of such oxidation on cell types present in the artery wall and in the circulation, respectively.
KW - Animals
KW - Apolipoprotein B-100
KW - Apolipoproteins B
KW - Atherosclerosis
KW - Humans
KW - Hypochlorous Acid
KW - Lipid Peroxidation
KW - Lipoproteins, LDL
KW - Oxidants
KW - Oxidation-Reduction
KW - Peroxidase
U2 - 10.1016/j.bbalip.2006.03.024
DO - 10.1016/j.bbalip.2006.03.024
M3 - Journal article
C2 - 16698314
SN - 0304-419X
VL - 1761
SP - 392
EP - 415
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 4
ER -
