Modeling the airflow in a lung with cystic fibrosis

TY - JOUR

T1 - Modeling the airflow in a lung with cystic fibrosis

AU - Zarei, Sara

AU - Mitar, Ali

AU - Andresen, Bjarne Bøgeskov

AU - Salamon, Peter

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Cystic fibrosis (CF) is a chronic progressive pulmonary disorder caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene. A CF lung is generally characterized by obstructed airflow to an extent that leads to destruction of airway wall support structure. Airway resistance, resulting from both laminar and turbulent flow, is an important mechanical factor contributing to flow of air into and out of the airways. There are numerous research studies focusing on airflow in the respiratory system that assumed flow to be only laminar and steady. The goal of this research is to describe the air flow mathematically by considering the resistance from both laminar and turbulent airflow throughout the entire respiratory tract. Furthermore, we implement a model that includes airway clogging in CF lungs and recalculate the rate of air flow given these obstructions.

AB - Cystic fibrosis (CF) is a chronic progressive pulmonary disorder caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene. A CF lung is generally characterized by obstructed airflow to an extent that leads to destruction of airway wall support structure. Airway resistance, resulting from both laminar and turbulent flow, is an important mechanical factor contributing to flow of air into and out of the airways. There are numerous research studies focusing on airflow in the respiratory system that assumed flow to be only laminar and steady. The goal of this research is to describe the air flow mathematically by considering the resistance from both laminar and turbulent airflow throughout the entire respiratory tract. Furthermore, we implement a model that includes airway clogging in CF lungs and recalculate the rate of air flow given these obstructions.

U2 - 10.1515/jnetdy-2012-0019

DO - 10.1515/jnetdy-2012-0019

M3 - Journal article

SN - 0340-0204

VL - 38

SP - 119

EP - 140

JO - Journal of Non-Equilibrium Thermodynamics

JF - Journal of Non-Equilibrium Thermodynamics

IS - 2

ER -