miRNAs in inflammatory skin diseases and their clinical implications

TY - JOUR

T1 - miRNAs in inflammatory skin diseases and their clinical implications

AU - Løvendorf, Marianne B

AU - Skov, Lone

PY - 2015/4/1

Y1 - 2015/4/1

N2 - miRNAs are a class of non-coding RNA molecules that modulate gene expression post-transcriptionally. They have a major impact on several physiological and pathological cellular processes including modulation of the innate and the adaptive immune system. The role of miRNAs in skin biology is still incomplete; however, it is known that miRNAs are implicated in various cellular processes of both normal and diseased skin. Some miRNAs appear to be consistently deregulated in several different inflammatory skin diseases, including psoriasis and atopic dermatitis, indicating a common role in fundamental biological processes. The clinical implications of miRNAs are intriguing, both from a diagnostic and a therapeutic perspective. Accordingly, there is emerging evidence for the clinical potential of miRNAs as both biomarkers and possible therapeutic targets in skin diseases. Future studies will hopefully establish the biological significance of miRNAs in skin biology, paving the way for new miRNA-based diagnostic and therapeutic applications in dermatology.

AB - miRNAs are a class of non-coding RNA molecules that modulate gene expression post-transcriptionally. They have a major impact on several physiological and pathological cellular processes including modulation of the innate and the adaptive immune system. The role of miRNAs in skin biology is still incomplete; however, it is known that miRNAs are implicated in various cellular processes of both normal and diseased skin. Some miRNAs appear to be consistently deregulated in several different inflammatory skin diseases, including psoriasis and atopic dermatitis, indicating a common role in fundamental biological processes. The clinical implications of miRNAs are intriguing, both from a diagnostic and a therapeutic perspective. Accordingly, there is emerging evidence for the clinical potential of miRNAs as both biomarkers and possible therapeutic targets in skin diseases. Future studies will hopefully establish the biological significance of miRNAs in skin biology, paving the way for new miRNA-based diagnostic and therapeutic applications in dermatology.

KW - Adaptive Immunity

KW - Animals

KW - Biological Therapy

KW - Biomarkers

KW - Dermatitis, Atopic

KW - Humans

KW - Immunity, Innate

KW - MicroRNAs

KW - Psoriasis

KW - Skin

U2 - 10.1586/1744666X.2015.1020301

DO - 10.1586/1744666X.2015.1020301

M3 - Journal article

C2 - 25719822

SN - 1744-666X

VL - 11

SP - 467

EP - 477

JO - Expert Review of Clinical Immunology

JF - Expert Review of Clinical Immunology

IS - 4

ER -