Minireview: Syndecans and their crucial roles during tissue regeneration

TY - JOUR

T1 - Minireview

T2 - Syndecans and their crucial roles during tissue regeneration

AU - Chung, Heesung

AU - Multhaupt, Hinke A B

AU - Oh, Eok-Soo

AU - Couchman, John R

N1 - © 2016 Federation of European Biochemical Societies.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Syndecans are transmembrane heparan sulfate proteoglycans, with roles in development, tumorigenesis and inflammation, and growing evidence for involvement in tissue regeneration. This is a fast developing field with the prospect of utilizing tissue engineering and biomaterials in novel therapies. Syndecan receptors are not only ubiquitous in mammalian tissues, regulating cell adhesion, migration, proliferation, and differentiation through independent signaling but also working alongside other receptors. Their importance is highlighted by an ability to interact with a diverse array of ligands, including extracellular matrix glycoproteins, growth factors, morphogens, and cytokines that are important regulators of regeneration. We also discuss the potential for syndecans to regulate stem cell properties, and suggest that understanding these proteoglycans is relevant to exploiting cell, tissue, and materials technologies.

AB - Syndecans are transmembrane heparan sulfate proteoglycans, with roles in development, tumorigenesis and inflammation, and growing evidence for involvement in tissue regeneration. This is a fast developing field with the prospect of utilizing tissue engineering and biomaterials in novel therapies. Syndecan receptors are not only ubiquitous in mammalian tissues, regulating cell adhesion, migration, proliferation, and differentiation through independent signaling but also working alongside other receptors. Their importance is highlighted by an ability to interact with a diverse array of ligands, including extracellular matrix glycoproteins, growth factors, morphogens, and cytokines that are important regulators of regeneration. We also discuss the potential for syndecans to regulate stem cell properties, and suggest that understanding these proteoglycans is relevant to exploiting cell, tissue, and materials technologies.

U2 - 10.1002/1873-3468.12280

DO - 10.1002/1873-3468.12280

M3 - Review

C2 - 27383370

SN - 0014-5793

VL - 590

SP - 2408

EP - 2417

JO - FEBS Letters

JF - FEBS Letters

IS - 15

ER -