TY - JOUR
T1 - Migraine and cluster headache - the common link
AU - Vollesen, Anne Luise
AU - Benemei, Silvia
AU - Cortese, Francesca
AU - Labastida-Ramírez, Alejandro
AU - Marchese, Francesca
AU - Pellesi, Lanfranco
AU - Romoli, Michele
AU - Ashina, Messoud
AU - Lampl, Christian
AU - School of Advanced Studies of the European Headache Federation (EHF-SAS)
PY - 2018/9/21
Y1 - 2018/9/21
N2 - Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients.
AB - Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients.
KW - Calcitonin Gene-Related Peptide/antagonists & inhibitors
KW - Cluster Headache/blood
KW - Deep Brain Stimulation/statistics & numerical data
KW - Humans
KW - Implantable Neurostimulators/statistics & numerical data
KW - Migraine Disorders/blood
KW - Nitroglycerin/adverse effects
KW - Tryptamines/pharmacology
U2 - 10.1186/s10194-018-0909-4
DO - 10.1186/s10194-018-0909-4
M3 - Review
C2 - 30242519
SN - 1129-2369
VL - 19
SP - 1
EP - 15
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
IS - 1
M1 - 89
ER -