Microtermolides A and B from termite-associated Streptomyces sp. and structural revision of vinylamycin

TY - JOUR

T1 - Microtermolides A and B from termite-associated Streptomyces sp. and structural revision of vinylamycin

AU - Carr, Gavin

AU - Poulsen, Michael

AU - Klassen, Jonathan L.

AU - Hou, Yanpeng

AU - Wyche, Thomas P.

AU - Bugni, Tim S.

AU - Currie, Cameron R.

AU - Clardy, Jon

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Microtermolides A (1) and B (2) were isolated from a Streptomyces sp. strain associated with fungus-growing termites. The structures of 1 and 2 were determined by 1D- and 2D-NMR spectroscopy and high-resolution mass spectrometry. Structural elucidation of 1 led to the re-examination of the structure originally proposed for vinylamycin (3). Based on a comparison of predicted and experimental (1)H and (13)C NMR chemical shifts, we propose that vinylamycin's structure be revised from 3 to 4.

AB - Microtermolides A (1) and B (2) were isolated from a Streptomyces sp. strain associated with fungus-growing termites. The structures of 1 and 2 were determined by 1D- and 2D-NMR spectroscopy and high-resolution mass spectrometry. Structural elucidation of 1 led to the re-examination of the structure originally proposed for vinylamycin (3). Based on a comparison of predicted and experimental (1)H and (13)C NMR chemical shifts, we propose that vinylamycin's structure be revised from 3 to 4.

U2 - 10.1021/ol301043p

DO - 10.1021/ol301043p

M3 - Journal article

C2 - 22591554

SN - 1523-7060

VL - 14

SP - 2822

EP - 2825

JO - Organic Letters

JF - Organic Letters

IS - 11

ER -