Microscopic colitis: Current status, present and future challenges: statements of the European Microscopic Colitis Group

TY - JOUR

T1 - Microscopic colitis

T2 - Current status, present and future challenges: statements of the European Microscopic Colitis Group

AU - Münch, A

AU - Aust, D

AU - Bohr, Jakob

AU - Bonderup, Ole Kristian

AU - Fernández Bañares, F

AU - Hjortswang, H

AU - Madisch, A

AU - Munck, L K

AU - Ström, M

AU - Tysk, C

AU - Miehlke, S

AU - European Microscopic Colitis Group (EMCG)

N1 - Copyright © 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

PY - 2012/10

Y1 - 2012/10

N2 - Microscopic colitis (MC) is an inflammatory bowel disease presenting with chronic, non-bloody watery diarrhoea and few or no endoscopic abnormalities. The histological examination reveals mainly two subtypes of MC, lymphocytic or collagenous colitis. Despite the fact that the incidence in MC has been rising over the last decades, research has been sparse and our knowledge about MC remains limited. Specialists in the field have initiated the European Microscopic Colitis Group (EMCG) with the primary goal to create awareness on MC. The EMCG is furthermore a forum with the intention to promote clinical and basic research. In this article statements and comments are given that all members of the EMCG have considered being of importance for a better understanding of MC. The paper focuses on the newest updates in epidemiology, symptoms and diagnostic criteria, pathophysiology and highlights some unsolved problems. Moreover, a new treatment algorithm is proposed on the basis of new evidence from well-designed, randomized control trials.

AB - Microscopic colitis (MC) is an inflammatory bowel disease presenting with chronic, non-bloody watery diarrhoea and few or no endoscopic abnormalities. The histological examination reveals mainly two subtypes of MC, lymphocytic or collagenous colitis. Despite the fact that the incidence in MC has been rising over the last decades, research has been sparse and our knowledge about MC remains limited. Specialists in the field have initiated the European Microscopic Colitis Group (EMCG) with the primary goal to create awareness on MC. The EMCG is furthermore a forum with the intention to promote clinical and basic research. In this article statements and comments are given that all members of the EMCG have considered being of importance for a better understanding of MC. The paper focuses on the newest updates in epidemiology, symptoms and diagnostic criteria, pathophysiology and highlights some unsolved problems. Moreover, a new treatment algorithm is proposed on the basis of new evidence from well-designed, randomized control trials.

KW - Algorithms

KW - Anti-Inflammatory Agents

KW - Budesonide

KW - Colitis, Microscopic

KW - Colonoscopy

KW - Diarrhea

KW - Humans

KW - Immunosuppressive Agents

KW - Probiotics

U2 - 10.1016/j.crohns.2012.05.014

DO - 10.1016/j.crohns.2012.05.014

M3 - Journal article

C2 - 22704658

SN - 1873-9946

VL - 6

SP - 932

EP - 945

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

IS - 9

ER -