MicroRNAs, Regulatory Networks, and Comorbidities: Decoding Complex Systems

Francesco Russo; Kirstine Belling; Anders Boeck Jensen; Flavia Scoyni; Søren Brunak; Marco Pellegrini

doi:10.1007/978-1-4939-6866-4_19

MicroRNAs, Regulatory Networks, and Comorbidities: Decoding Complex Systems

Francesco Russo, Kirstine Belling, Anders Boeck Jensen, Flavia Scoyni, Søren Brunak, Marco Pellegrini

Disease Systems Biology Program

1 Citationer (Scopus)

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs involved in the posttranscriptional regulation of messenger RNAs (mRNAs). Each miRNA targets a specific set of mRNAs. Upon binding the miRNA inhibits mRNA translation or facilitate mRNA degradation. miRNAs are frequently deregulated in several pathologies including cancer and cardiovascular diseases. Since miRNAs have a crucial role in fine-tuning the expression of their targets, they have been proposed as biomarkers of disease progression and prognostication.In this chapter we discuss different approaches for computational predictions of miRNA targets based on sequence complementarity and integration of expression data. In the last section of the chapter we discuss new opportunities in the study of miRNA regulatory networks in the context of temporal disease progression and comorbidities.

Originalsprog	Engelsk
Tidsskrift	Methods in molecular biology (Clifton, N.J.)
Vol/bind	1580
Sider (fra-til)	281-295
Antal sider	15
ISSN	1064-3745
DOI	https://doi.org/10.1007/978-1-4939-6866-4_19
Status	Udgivet - 2017

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10.1007/978-1-4939-6866-4_19

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T2 - Decoding Complex Systems

AU - Russo, Francesco

AU - Belling, Kirstine

AU - Jensen, Anders Boeck

AU - Scoyni, Flavia

AU - Brunak, Søren

AU - Pellegrini, Marco

PY - 2017

Y1 - 2017

N2 - MicroRNAs (miRNAs) are small noncoding RNAs involved in the posttranscriptional regulation of messenger RNAs (mRNAs). Each miRNA targets a specific set of mRNAs. Upon binding the miRNA inhibits mRNA translation or facilitate mRNA degradation. miRNAs are frequently deregulated in several pathologies including cancer and cardiovascular diseases. Since miRNAs have a crucial role in fine-tuning the expression of their targets, they have been proposed as biomarkers of disease progression and prognostication.In this chapter we discuss different approaches for computational predictions of miRNA targets based on sequence complementarity and integration of expression data. In the last section of the chapter we discuss new opportunities in the study of miRNA regulatory networks in the context of temporal disease progression and comorbidities.

AB - MicroRNAs (miRNAs) are small noncoding RNAs involved in the posttranscriptional regulation of messenger RNAs (mRNAs). Each miRNA targets a specific set of mRNAs. Upon binding the miRNA inhibits mRNA translation or facilitate mRNA degradation. miRNAs are frequently deregulated in several pathologies including cancer and cardiovascular diseases. Since miRNAs have a crucial role in fine-tuning the expression of their targets, they have been proposed as biomarkers of disease progression and prognostication.In this chapter we discuss different approaches for computational predictions of miRNA targets based on sequence complementarity and integration of expression data. In the last section of the chapter we discuss new opportunities in the study of miRNA regulatory networks in the context of temporal disease progression and comorbidities.

KW - Journal Article

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JO - Methods in molecular biology (Clifton, N.J.)

JF - Methods in molecular biology (Clifton, N.J.)

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MicroRNAs, Regulatory Networks, and Comorbidities: Decoding Complex Systems

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