Methylphenidate misuse in adult patients and the impact of therapeutic use

L S Jensen; Anne Katrine Pagsberg; Kim Dalhoff

doi:10.1177/0960327114543935

Methylphenidate misuse in adult patients and the impact of therapeutic use

L S Jensen, Anne Katrine Pagsberg, Kim Dalhoff

Institut for Klinisk Medicin

4 Citationer (Scopus)

Abstract

OBJECTIVE: Methylphenidate (MPH) prescription rates for adults increase, but the extent of a parallel rise in toxic exposures and their causes and distribution between different MPH trade names are unexplored.

METHOD: We retrospectively analyzed adult MPH exposures reported to the Danish Poison Information Centre from January 2006 to July 2012 and the association with MPH sales and the number of patients prescribed MPH.

RESULTS: Of the 394 exposures (57% males, median age 27 years) reported, MPH status was available in 249 of whom 65.5% were prescribed MPH. Exposure was in 54% motivated by suicidal attempt and in 40% by recreational use (based on 375 cases). Exposure was dominated by one trade name and exposure incidence correlated significantly with sales ( p = 0.001) and prevalence of MPH-treated patients ( p = 0.0008).

CONCLUSIONS: The increase in MPH exposures parallels the prescription rates (particularly Ritalin(®)/Ritalin(®) Uno). Most exposures were intentional and motivated by suicide attempts or recreational use.

Originalsprog	Engelsk
Tidsskrift	Human & Experimental Toxicology
Vol/bind	34
Udgave nummer	5
Sider (fra-til)	460-467
Antal sider	8
ISSN	0960-3271
DOI	https://doi.org/10.1177/0960327114543935
Status	Udgivet - 21 maj 2015

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10.1177/0960327114543935

https://journals.sagepub.com/doi/pdf/10.1177/0960327114543935

Citationsformater

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title = "Methylphenidate misuse in adult patients and the impact of therapeutic use",

abstract = "OBJECTIVE: Methylphenidate (MPH) prescription rates for adults increase, but the extent of a parallel rise in toxic exposures and their causes and distribution between different MPH trade names are unexplored.METHOD: We retrospectively analyzed adult MPH exposures reported to the Danish Poison Information Centre from January 2006 to July 2012 and the association with MPH sales and the number of patients prescribed MPH.RESULTS: Of the 394 exposures (57% males, median age 27 years) reported, MPH status was available in 249 of whom 65.5% were prescribed MPH. Exposure was in 54% motivated by suicidal attempt and in 40% by recreational use (based on 375 cases). Exposure was dominated by one trade name and exposure incidence correlated significantly with sales ( p = 0.001) and prevalence of MPH-treated patients ( p = 0.0008).CONCLUSIONS: The increase in MPH exposures parallels the prescription rates (particularly Ritalin({\textregistered})/Ritalin({\textregistered}) Uno). Most exposures were intentional and motivated by suicide attempts or recreational use.",

author = "Jensen, {L S} and Pagsberg, {Anne Katrine} and Kim Dalhoff",

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T1 - Methylphenidate misuse in adult patients and the impact of therapeutic use

AU - Jensen, L S

AU - Pagsberg, Anne Katrine

AU - Dalhoff, Kim

PY - 2015/5/21

Y1 - 2015/5/21

N2 - OBJECTIVE: Methylphenidate (MPH) prescription rates for adults increase, but the extent of a parallel rise in toxic exposures and their causes and distribution between different MPH trade names are unexplored.METHOD: We retrospectively analyzed adult MPH exposures reported to the Danish Poison Information Centre from January 2006 to July 2012 and the association with MPH sales and the number of patients prescribed MPH.RESULTS: Of the 394 exposures (57% males, median age 27 years) reported, MPH status was available in 249 of whom 65.5% were prescribed MPH. Exposure was in 54% motivated by suicidal attempt and in 40% by recreational use (based on 375 cases). Exposure was dominated by one trade name and exposure incidence correlated significantly with sales ( p = 0.001) and prevalence of MPH-treated patients ( p = 0.0008).CONCLUSIONS: The increase in MPH exposures parallels the prescription rates (particularly Ritalin(®)/Ritalin(®) Uno). Most exposures were intentional and motivated by suicide attempts or recreational use.

AB - OBJECTIVE: Methylphenidate (MPH) prescription rates for adults increase, but the extent of a parallel rise in toxic exposures and their causes and distribution between different MPH trade names are unexplored.METHOD: We retrospectively analyzed adult MPH exposures reported to the Danish Poison Information Centre from January 2006 to July 2012 and the association with MPH sales and the number of patients prescribed MPH.RESULTS: Of the 394 exposures (57% males, median age 27 years) reported, MPH status was available in 249 of whom 65.5% were prescribed MPH. Exposure was in 54% motivated by suicidal attempt and in 40% by recreational use (based on 375 cases). Exposure was dominated by one trade name and exposure incidence correlated significantly with sales ( p = 0.001) and prevalence of MPH-treated patients ( p = 0.0008).CONCLUSIONS: The increase in MPH exposures parallels the prescription rates (particularly Ritalin(®)/Ritalin(®) Uno). Most exposures were intentional and motivated by suicide attempts or recreational use.

U2 - 10.1177/0960327114543935

DO - 10.1177/0960327114543935

M3 - Journal article

C2 - 25062974

SN - 0960-3271

VL - 34

SP - 460

EP - 467

JO - Human & Experimental Toxicology

JF - Human & Experimental Toxicology

IS - 5

ER -

Methylphenidate misuse in adult patients and the impact of therapeutic use

Abstract

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