TY - JOUR
T1 - Metazoan promoters
T2 - emerging characteristics and insights into transcriptional regulation
AU - Lenhard, Boris
AU - Sandelin, Albin Gustav
AU - Carninci, Piero
PY - 2012/4
Y1 - 2012/4
N2 - Promoters are crucial for gene regulation. They vary greatly in terms of associated regulatory elements, sequence motifs, the choice of transcription start sites and other features. Several technologies that harness next-generation sequencing have enabled recent advances in identifying promoters and their features, helping researchers who are investigating functional categories of promoters and their modes of regulation. Additional features of promoters that are being characterized include types of histone modifications, nucleosome positioning, RNA polymerase pausing and novel small RNAs. In this Review, we discuss recent findings relating to metazoan promoters and how these findings are leading to a revised picture of what a gene promoter is and how it works.
AB - Promoters are crucial for gene regulation. They vary greatly in terms of associated regulatory elements, sequence motifs, the choice of transcription start sites and other features. Several technologies that harness next-generation sequencing have enabled recent advances in identifying promoters and their features, helping researchers who are investigating functional categories of promoters and their modes of regulation. Additional features of promoters that are being characterized include types of histone modifications, nucleosome positioning, RNA polymerase pausing and novel small RNAs. In this Review, we discuss recent findings relating to metazoan promoters and how these findings are leading to a revised picture of what a gene promoter is and how it works.
U2 - 10.1038/nrg3163
DO - 10.1038/nrg3163
M3 - Journal article
C2 - 22392219
SN - 1471-0056
VL - 13
SP - 233
EP - 245
JO - Nature Reviews. Genetics
JF - Nature Reviews. Genetics
IS - 4
ER -