Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men

Ping Wang; Paul P C A Menheere; Arne Astrup; Malene R Andersen; Marleen A van Baak; Thomas Meinert Larsen; Susan Jebb; Anthony Kafatos; Andreas F H Pfeiffer; J Alfredo Martinez; Teodora Handjieva-Darlenska; Petr Hlavaty; Nathalie Viguerie; Dominique Langin; Wim H M Saris; Edwin C M Mariman; on behalf of Diogenes consortium

doi:10.1002/oby.20311

Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men

Ping Wang, Paul P C A Menheere, Arne Astrup, Malene R Andersen, Marleen A van Baak, Thomas Meinert Larsen, Susan Jebb, Anthony Kafatos, Andreas F H Pfeiffer, J Alfredo Martinez, Teodora Handjieva-Darlenska, Petr Hlavaty, Nathalie Viguerie, Dominique Langin, Wim H M Saris, Edwin C M Mariman, on behalf of Diogenes consortium

14 Citationer (Scopus)

Abstract

Objective Weight loss helps reduce the symptoms of the metabolic syndrome (MetS) in the obese, but weight regain after active weight loss is common. The changes and predictive role of circulating adipokines and sex hormones for weight regain in men during dietary intervention, and also the effect of basal MetS status on weight regain, were investigated. Design and Methods Twenty-four men who continued to lose weight (WL) and 24 men who regained weight (WR) during the 6-month follow-up period after weight loss were selected from the Diogenes Study. Their circulating concentrations of leptin, adiponectin, retinol-binding protein 4 (RBP4), luteinizing hormone, prolactin, progesterone, total and free testosterone, and sex hormone-binding globulin (SHBG) were measured at baseline, after 8-week low-calorie diet-induced active weight loss, and after a subsequent 26-week ad libitum weight maintenance diet, and analyzed together with anthropometrical and physiological parameters. Results Overweight and obese men with MetS at baseline had higher risk to regain weight (odds ratio = 2.8, P = 0.015). High baseline RBP4, low total testosterone, and low SHBG are predictors of weight loss regain (different between WR and WL with P = 0.001, 0.038, and 0.044, respectively). Conclusions These variables may play roles in the link between MetS and weight loss regain.

Originalsprog	Engelsk
Tidsskrift	Obesity
Vol/bind	21
Udgave nummer	10
Sider (fra-til)	1997-2006
Antal sider	10
ISSN	1930-7381
DOI	https://doi.org/10.1002/oby.20311
Status	Udgivet - okt. 2013

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10.1002/oby.20311

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/oby.20311

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Wang, P., Menheere, P. P. C. A., Astrup, A., Andersen, M. R., Baak, M. A. V., Larsen, T. M., Jebb, S., Kafatos, A., Pfeiffer, A. F. H., Martinez, J. A., Handjieva-Darlenska, T., Hlavaty, P., Viguerie, N., Langin, D., Saris, W. H. M., Mariman, E. C. M., & on behalf of Diogenes consortium (2013). Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men. Obesity, 21(10), 1997-2006. https://doi.org/10.1002/oby.20311

Wang, P, Menheere, PPCA, Astrup, A, Andersen, MR, Baak, MAV, Larsen, TM, Jebb, S, Kafatos, A, Pfeiffer, AFH, Martinez, JA, Handjieva-Darlenska, T, Hlavaty, P, Viguerie, N, Langin, D, Saris, WHM, Mariman, ECM & on behalf of Diogenes consortium 2013, 'Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men', Obesity, bind 21, nr. 10, s. 1997-2006. https://doi.org/10.1002/oby.20311

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title = "Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men",

abstract = "Objective Weight loss helps reduce the symptoms of the metabolic syndrome (MetS) in the obese, but weight regain after active weight loss is common. The changes and predictive role of circulating adipokines and sex hormones for weight regain in men during dietary intervention, and also the effect of basal MetS status on weight regain, were investigated. Design and Methods Twenty-four men who continued to lose weight (WL) and 24 men who regained weight (WR) during the 6-month follow-up period after weight loss were selected from the Diogenes Study. Their circulating concentrations of leptin, adiponectin, retinol-binding protein 4 (RBP4), luteinizing hormone, prolactin, progesterone, total and free testosterone, and sex hormone-binding globulin (SHBG) were measured at baseline, after 8-week low-calorie diet-induced active weight loss, and after a subsequent 26-week ad libitum weight maintenance diet, and analyzed together with anthropometrical and physiological parameters. Results Overweight and obese men with MetS at baseline had higher risk to regain weight (odds ratio = 2.8, P = 0.015). High baseline RBP4, low total testosterone, and low SHBG are predictors of weight loss regain (different between WR and WL with P = 0.001, 0.038, and 0.044, respectively). Conclusions These variables may play roles in the link between MetS and weight loss regain.",

author = "Ping Wang and Menheere, {Paul P C A} and Arne Astrup and Andersen, {Malene R} and Baak, {Marleen A van} and Larsen, {Thomas Meinert} and Susan Jebb and Anthony Kafatos and Pfeiffer, {Andreas F H} and Martinez, {J Alfredo} and Teodora Handjieva-Darlenska and Petr Hlavaty and Nathalie Viguerie and Dominique Langin and Saris, {Wim H M} and Mariman, {Edwin C M} and {on behalf of Diogenes consortium}",

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year = "2013",

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doi = "10.1002/oby.20311",

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TY - JOUR

T1 - Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men

AU - Wang, Ping

AU - Menheere, Paul P C A

AU - Astrup, Arne

AU - Andersen, Malene R

AU - Baak, Marleen A van

AU - Larsen, Thomas Meinert

AU - Jebb, Susan

AU - Kafatos, Anthony

AU - Pfeiffer, Andreas F H

AU - Martinez, J Alfredo

AU - Handjieva-Darlenska, Teodora

AU - Hlavaty, Petr

AU - Viguerie, Nathalie

AU - Langin, Dominique

AU - Saris, Wim H M

AU - Mariman, Edwin C M

AU - on behalf of Diogenes consortium

N1 - CURIS 2013 NEXS 076

PY - 2013/10

Y1 - 2013/10

N2 - Objective Weight loss helps reduce the symptoms of the metabolic syndrome (MetS) in the obese, but weight regain after active weight loss is common. The changes and predictive role of circulating adipokines and sex hormones for weight regain in men during dietary intervention, and also the effect of basal MetS status on weight regain, were investigated. Design and Methods Twenty-four men who continued to lose weight (WL) and 24 men who regained weight (WR) during the 6-month follow-up period after weight loss were selected from the Diogenes Study. Their circulating concentrations of leptin, adiponectin, retinol-binding protein 4 (RBP4), luteinizing hormone, prolactin, progesterone, total and free testosterone, and sex hormone-binding globulin (SHBG) were measured at baseline, after 8-week low-calorie diet-induced active weight loss, and after a subsequent 26-week ad libitum weight maintenance diet, and analyzed together with anthropometrical and physiological parameters. Results Overweight and obese men with MetS at baseline had higher risk to regain weight (odds ratio = 2.8, P = 0.015). High baseline RBP4, low total testosterone, and low SHBG are predictors of weight loss regain (different between WR and WL with P = 0.001, 0.038, and 0.044, respectively). Conclusions These variables may play roles in the link between MetS and weight loss regain.

AB - Objective Weight loss helps reduce the symptoms of the metabolic syndrome (MetS) in the obese, but weight regain after active weight loss is common. The changes and predictive role of circulating adipokines and sex hormones for weight regain in men during dietary intervention, and also the effect of basal MetS status on weight regain, were investigated. Design and Methods Twenty-four men who continued to lose weight (WL) and 24 men who regained weight (WR) during the 6-month follow-up period after weight loss were selected from the Diogenes Study. Their circulating concentrations of leptin, adiponectin, retinol-binding protein 4 (RBP4), luteinizing hormone, prolactin, progesterone, total and free testosterone, and sex hormone-binding globulin (SHBG) were measured at baseline, after 8-week low-calorie diet-induced active weight loss, and after a subsequent 26-week ad libitum weight maintenance diet, and analyzed together with anthropometrical and physiological parameters. Results Overweight and obese men with MetS at baseline had higher risk to regain weight (odds ratio = 2.8, P = 0.015). High baseline RBP4, low total testosterone, and low SHBG are predictors of weight loss regain (different between WR and WL with P = 0.001, 0.038, and 0.044, respectively). Conclusions These variables may play roles in the link between MetS and weight loss regain.

U2 - 10.1002/oby.20311

DO - 10.1002/oby.20311

M3 - Journal article

C2 - 23408763

SN - 1930-7381

VL - 21

SP - 1997

EP - 2006

JO - Obesity

JF - Obesity

IS - 10

ER -

Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men

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