Metabolic Rather Than Body Composition Measurements Are Associated With Lower Serum Natriuretic Peptide Concentrations in Normal Weight and Obese Men

Camilla L Asferg; Søren J Nielsen; Ulrik B Andersen; Allan Linneberg; Daniel V Møller; Paula L Hedley; Michael Christiansen; Jens P Gøtze; Jørgen L Jeppesen

doi:10.1093/ajh/hpt145

Metabolic Rather Than Body Composition Measurements Are Associated With Lower Serum Natriuretic Peptide Concentrations in Normal Weight and Obese Men

Camilla L Asferg, Søren J Nielsen, Ulrik B Andersen, Allan Linneberg, Daniel V Møller, Paula L Hedley, Michael Christiansen, Jens P Gøtze, Jørgen L Jeppesen

12 Citationer (Scopus)

Abstract

BACKGROUND: Several studies have shown that obese persons have lower circulating natriuretic peptide (NP) concentrations. The cause of the relative NP deficiency seen in obese persons is poorly understood, although variation in body composition and metabolic abnormalities has been suggested to play a role. Thus, the aim of this study was to assess whether variation in circulating NP concentrations would be associated with differences in metabolic disturbances rather than with differences in body composition.

METHODS: In 27 normal weight men (body mass index (BMI) = 20.0-24.9kg/m(2)) and 103 obese men (BMI ≥ 30kg/m(2)), we determined body composition (total, android, and gynoid fat mass) by dual energy x-ray absorptiometry scanning, and we measured fasting serum concentrations of midregional proatrial NP (MR-proANP) and insulin, as well as fasting plasma glucose concentrations.

RESULTS: Mean weight ± SD was 74.9±6.7kg in the normal weight men and 106.1±10.8kg in obese men. Applying multiple regressions, adjusting for age and weight status (normal weight vs. obese), serum MR-proANP concentrations were significantly inversely associated with serum insulin concentrations (β = -0.39; P < 0.0001) and plasma glucose concentrations (β = -0.21; P = 0.02) but not with total (β = 0.00), android (β = -0.01), or gynoid (β = 0.03) fat mass percentage (P > 0.76). No significant interaction effects between metabolic measurements or body composition measurements and weight status on MR-proANP concentrations were found (P > 0.08).

CONCLUSIONS: In normal weight and obese men, lower circulating NP concentrations are associated with higher insulin and glucose concentrations and not with the proportion of total fat mass or the distribution of fat mass.

Originalsprog	Engelsk
Tidsskrift	American Journal of Hypertension
Vol/bind	27
Udgave nummer	4
Sider (fra-til)	620-627
Antal sider	8
ISSN	0895-7061
DOI	https://doi.org/10.1093/ajh/hpt145
Status	Udgivet - apr. 2014

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10.1093/ajh/hpt145

https://academic.oup.com/ajh/article-pdf/27/4/620/8663873/hpt145.pdf

Citationsformater

Asferg, C. L., Nielsen, S. J., Andersen, U. B., Linneberg, A., Møller, D. V., Hedley, P. L., Christiansen, M., Gøtze, J. P., & Jeppesen, J. L. (2014). Metabolic Rather Than Body Composition Measurements Are Associated With Lower Serum Natriuretic Peptide Concentrations in Normal Weight and Obese Men. American Journal of Hypertension, 27(4), 620-627. https://doi.org/10.1093/ajh/hpt145

Metabolic Rather Than Body Composition Measurements Are Associated With Lower Serum Natriuretic Peptide Concentrations in Normal Weight and Obese Men. / Asferg, Camilla L; Nielsen, Søren J; Andersen, Ulrik B et al.
I: American Journal of Hypertension, Bind 27, Nr. 4, 04.2014, s. 620-627.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Asferg, CL, Nielsen, SJ, Andersen, UB, Linneberg, A, Møller, DV, Hedley, PL, Christiansen, M, Gøtze, JP & Jeppesen, JL 2014, 'Metabolic Rather Than Body Composition Measurements Are Associated With Lower Serum Natriuretic Peptide Concentrations in Normal Weight and Obese Men', American Journal of Hypertension, bind 27, nr. 4, s. 620-627. https://doi.org/10.1093/ajh/hpt145

@article{203b05190b5e4ed889d51b684b6152f3,

title = "Metabolic Rather Than Body Composition Measurements Are Associated With Lower Serum Natriuretic Peptide Concentrations in Normal Weight and Obese Men",

abstract = "BACKGROUND: Several studies have shown that obese persons have lower circulating natriuretic peptide (NP) concentrations. The cause of the relative NP deficiency seen in obese persons is poorly understood, although variation in body composition and metabolic abnormalities has been suggested to play a role. Thus, the aim of this study was to assess whether variation in circulating NP concentrations would be associated with differences in metabolic disturbances rather than with differences in body composition.METHODS: In 27 normal weight men (body mass index (BMI) = 20.0-24.9kg/m(2)) and 103 obese men (BMI ≥ 30kg/m(2)), we determined body composition (total, android, and gynoid fat mass) by dual energy x-ray absorptiometry scanning, and we measured fasting serum concentrations of midregional proatrial NP (MR-proANP) and insulin, as well as fasting plasma glucose concentrations.RESULTS: Mean weight ± SD was 74.9±6.7kg in the normal weight men and 106.1±10.8kg in obese men. Applying multiple regressions, adjusting for age and weight status (normal weight vs. obese), serum MR-proANP concentrations were significantly inversely associated with serum insulin concentrations (β = -0.39; P < 0.0001) and plasma glucose concentrations (β = -0.21; P = 0.02) but not with total (β = 0.00), android (β = -0.01), or gynoid (β = 0.03) fat mass percentage (P > 0.76). No significant interaction effects between metabolic measurements or body composition measurements and weight status on MR-proANP concentrations were found (P > 0.08).CONCLUSIONS: In normal weight and obese men, lower circulating NP concentrations are associated with higher insulin and glucose concentrations and not with the proportion of total fat mass or the distribution of fat mass.",

keywords = "Adult, Aged, Atrial Natriuretic Factor, Blood Glucose, Body Composition, Body Mass Index, Cross-Sectional Studies, Humans, Insulin, Male, Middle Aged, Obesity",

author = "Asferg, {Camilla L} and Nielsen, {S{\o}ren J} and Andersen, {Ulrik B} and Allan Linneberg and M{\o}ller, {Daniel V} and Hedley, {Paula L} and Michael Christiansen and G{\o}tze, {Jens P} and Jeppesen, {J{\o}rgen L}",

year = "2014",

month = apr,

doi = "10.1093/ajh/hpt145",

language = "English",

volume = "27",

pages = "620--627",

journal = "American Journal of Hypertension",

issn = "0895-7061",

publisher = "Oxford University Press",

number = "4",

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TY - JOUR

T1 - Metabolic Rather Than Body Composition Measurements Are Associated With Lower Serum Natriuretic Peptide Concentrations in Normal Weight and Obese Men

AU - Asferg, Camilla L

AU - Nielsen, Søren J

AU - Andersen, Ulrik B

AU - Linneberg, Allan

AU - Møller, Daniel V

AU - Hedley, Paula L

AU - Christiansen, Michael

AU - Gøtze, Jens P

AU - Jeppesen, Jørgen L

PY - 2014/4

Y1 - 2014/4

N2 - BACKGROUND: Several studies have shown that obese persons have lower circulating natriuretic peptide (NP) concentrations. The cause of the relative NP deficiency seen in obese persons is poorly understood, although variation in body composition and metabolic abnormalities has been suggested to play a role. Thus, the aim of this study was to assess whether variation in circulating NP concentrations would be associated with differences in metabolic disturbances rather than with differences in body composition.METHODS: In 27 normal weight men (body mass index (BMI) = 20.0-24.9kg/m(2)) and 103 obese men (BMI ≥ 30kg/m(2)), we determined body composition (total, android, and gynoid fat mass) by dual energy x-ray absorptiometry scanning, and we measured fasting serum concentrations of midregional proatrial NP (MR-proANP) and insulin, as well as fasting plasma glucose concentrations.RESULTS: Mean weight ± SD was 74.9±6.7kg in the normal weight men and 106.1±10.8kg in obese men. Applying multiple regressions, adjusting for age and weight status (normal weight vs. obese), serum MR-proANP concentrations were significantly inversely associated with serum insulin concentrations (β = -0.39; P < 0.0001) and plasma glucose concentrations (β = -0.21; P = 0.02) but not with total (β = 0.00), android (β = -0.01), or gynoid (β = 0.03) fat mass percentage (P > 0.76). No significant interaction effects between metabolic measurements or body composition measurements and weight status on MR-proANP concentrations were found (P > 0.08).CONCLUSIONS: In normal weight and obese men, lower circulating NP concentrations are associated with higher insulin and glucose concentrations and not with the proportion of total fat mass or the distribution of fat mass.

AB - BACKGROUND: Several studies have shown that obese persons have lower circulating natriuretic peptide (NP) concentrations. The cause of the relative NP deficiency seen in obese persons is poorly understood, although variation in body composition and metabolic abnormalities has been suggested to play a role. Thus, the aim of this study was to assess whether variation in circulating NP concentrations would be associated with differences in metabolic disturbances rather than with differences in body composition.METHODS: In 27 normal weight men (body mass index (BMI) = 20.0-24.9kg/m(2)) and 103 obese men (BMI ≥ 30kg/m(2)), we determined body composition (total, android, and gynoid fat mass) by dual energy x-ray absorptiometry scanning, and we measured fasting serum concentrations of midregional proatrial NP (MR-proANP) and insulin, as well as fasting plasma glucose concentrations.RESULTS: Mean weight ± SD was 74.9±6.7kg in the normal weight men and 106.1±10.8kg in obese men. Applying multiple regressions, adjusting for age and weight status (normal weight vs. obese), serum MR-proANP concentrations were significantly inversely associated with serum insulin concentrations (β = -0.39; P < 0.0001) and plasma glucose concentrations (β = -0.21; P = 0.02) but not with total (β = 0.00), android (β = -0.01), or gynoid (β = 0.03) fat mass percentage (P > 0.76). No significant interaction effects between metabolic measurements or body composition measurements and weight status on MR-proANP concentrations were found (P > 0.08).CONCLUSIONS: In normal weight and obese men, lower circulating NP concentrations are associated with higher insulin and glucose concentrations and not with the proportion of total fat mass or the distribution of fat mass.

KW - Adult

KW - Aged

KW - Atrial Natriuretic Factor

KW - Blood Glucose

KW - Body Composition

KW - Body Mass Index

KW - Cross-Sectional Studies

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

KW - Obesity

U2 - 10.1093/ajh/hpt145

DO - 10.1093/ajh/hpt145

M3 - Journal article

C2 - 24025723

SN - 0895-7061

VL - 27

SP - 620

EP - 627

JO - American Journal of Hypertension

JF - American Journal of Hypertension

IS - 4

ER -

Metabolic Rather Than Body Composition Measurements Are Associated With Lower Serum Natriuretic Peptide Concentrations in Normal Weight and Obese Men

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