Mesenchymal stem cell therapy for salivary gland dysfunction and xerostomia: a systematic review of preclinical studies

David Hebbelstrup Jensen; Roberto Stefan Oliveri; Stig-Frederik Trojahn-Kølle; Anne Fischer-Nielsen; Lena Specht; Allan Bardow Jensen; Christian von Buchwald

doi:10.1016/j.oooo.2013.11.496

Mesenchymal stem cell therapy for salivary gland dysfunction and xerostomia: a systematic review of preclinical studies

David Hebbelstrup Jensen, Roberto Stefan Oliveri, Stig-Frederik Trojahn-Kølle, Anne Fischer-Nielsen, Lena Specht, Allan Bardow Jensen, Christian von Buchwald

20 Citationer (Scopus)

Abstract

The most severe forms of xerostomia and salivary gland dysfunction, as well as a severely reduced quality of life, are seen in Sjögren syndrome (SS) and after radiotherapy for head and neck cancer. For both conditions, no effective regenerative therapies yet exist. Thus, the aim of this article was to assess, through systematic review, the potential benefit of mesenchymal stem cell (MSC) therapy in radiation-induced and SS-related salivary gland dysfunction and xerostomia. We searched PubMed/MEDLINE, Embase, Web of Science, the Cochrane Database of Systematic Reviews, the World Health Organization Clinical Trials Registry Platform, and Google Scholar. We identified 6 separate study comparisons eligible for inclusion. Owing to the limited number of studies, we conclude that more randomized, adequately powered clinical trials are needed to validate the potential beneficial effect of MSCs on salivary gland dysfunction and xerostomia. Nonetheless, the preliminary studies identified in the present review were encouraging for further research.

Originalsprog	Engelsk
Tidsskrift	Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
Vol/bind	117
Udgave nummer	3
Sider (fra-til)	335-342
Antal sider	8
ISSN	1079-2104
DOI	https://doi.org/10.1016/j.oooo.2013.11.496
Status	Udgivet - mar. 2014

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10.1016/j.oooo.2013.11.496

http://www.ncbi.nlm.nih.gov/pubmed/24528792

Citationsformater

Jensen, D. H., Oliveri, R. S., Trojahn-Kølle, S-F., Fischer-Nielsen, A., Specht, L., Jensen, A. B., & von Buchwald, C. (2014). Mesenchymal stem cell therapy for salivary gland dysfunction and xerostomia: a systematic review of preclinical studies. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 117(3), 335-342. https://doi.org/10.1016/j.oooo.2013.11.496

Mesenchymal stem cell therapy for salivary gland dysfunction and xerostomia: a systematic review of preclinical studies. / Jensen, David Hebbelstrup; Oliveri, Roberto Stefan; Trojahn-Kølle, Stig-Frederik et al.

I: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, Bind 117, Nr. 3, 03.2014, s. 335-342.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Jensen, DH, Oliveri, RS, Trojahn-Kølle, S-F, Fischer-Nielsen, A , Specht, L, Jensen, AB & von Buchwald, C 2014, 'Mesenchymal stem cell therapy for salivary gland dysfunction and xerostomia: a systematic review of preclinical studies', Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, bind 117, nr. 3, s. 335-342. https://doi.org/10.1016/j.oooo.2013.11.496

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title = "Mesenchymal stem cell therapy for salivary gland dysfunction and xerostomia: a systematic review of preclinical studies",

abstract = "The most severe forms of xerostomia and salivary gland dysfunction, as well as a severely reduced quality of life, are seen in Sj{\"o}gren syndrome (SS) and after radiotherapy for head and neck cancer. For both conditions, no effective regenerative therapies yet exist. Thus, the aim of this article was to assess, through systematic review, the potential benefit of mesenchymal stem cell (MSC) therapy in radiation-induced and SS-related salivary gland dysfunction and xerostomia. We searched PubMed/MEDLINE, Embase, Web of Science, the Cochrane Database of Systematic Reviews, the World Health Organization Clinical Trials Registry Platform, and Google Scholar. We identified 6 separate study comparisons eligible for inclusion. Owing to the limited number of studies, we conclude that more randomized, adequately powered clinical trials are needed to validate the potential beneficial effect of MSCs on salivary gland dysfunction and xerostomia. Nonetheless, the preliminary studies identified in the present review were encouraging for further research.",

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AU - Jensen, David Hebbelstrup

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AU - Fischer-Nielsen, Anne

AU - Specht, Lena

AU - Jensen, Allan Bardow

AU - von Buchwald, Christian

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AB - The most severe forms of xerostomia and salivary gland dysfunction, as well as a severely reduced quality of life, are seen in Sjögren syndrome (SS) and after radiotherapy for head and neck cancer. For both conditions, no effective regenerative therapies yet exist. Thus, the aim of this article was to assess, through systematic review, the potential benefit of mesenchymal stem cell (MSC) therapy in radiation-induced and SS-related salivary gland dysfunction and xerostomia. We searched PubMed/MEDLINE, Embase, Web of Science, the Cochrane Database of Systematic Reviews, the World Health Organization Clinical Trials Registry Platform, and Google Scholar. We identified 6 separate study comparisons eligible for inclusion. Owing to the limited number of studies, we conclude that more randomized, adequately powered clinical trials are needed to validate the potential beneficial effect of MSCs on salivary gland dysfunction and xerostomia. Nonetheless, the preliminary studies identified in the present review were encouraging for further research.

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Mesenchymal stem cell therapy for salivary gland dysfunction and xerostomia: a systematic review of preclinical studies

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