Membrane sialic acid influences basophil histamine release by interfering with calcium dependence

C Jensen; S Norn; P S Skov; B T Dahl; Ole Thastrup; A Leon; U G Svendsen

Membrane sialic acid influences basophil histamine release by interfering with calcium dependence

C Jensen, S Norn, P S Skov, B T Dahl, Ole Thastrup, A Leon, U G Svendsen

4 Citationer (Scopus)

Abstract

The influence of the cell membrane content of sialic acid on basophil histamine release was examined in vitro in allergic patients and normal controls. Enzymatical removal of sialic acid enhanced histamine release induced by allergen and anti-IgE, whereas an increase in membrane sialic acid content by insertion of sialic acid containing gangliosides into the membrane inhibited the mediator release. The reduction in membrane sialic acid content abolished the inhibitory capacity of the calcium channel antagonist nimodipine, whereas the inhibition produced by verapamil and lanthanum was not affected. This difference, together with the previous finding that alterations in membrane sialic acid content is reflected in the cell sensitivity to extracellular calcium, suggest an interaction between membrane sialic acid and the calcium channels involved in basophil histamine release.

Originalsprog	Engelsk
Tidsskrift	Agents and Actions
Vol/bind	20
Udgave nummer	3-4
Sider (fra-til)	161-4
Antal sider	4
ISSN	0065-4299
Status	Udgivet - 1987

Citationsformater

@article{8167f4771b8b4ccdbc15d6e092efe46f,

title = "Membrane sialic acid influences basophil histamine release by interfering with calcium dependence",

abstract = "The influence of the cell membrane content of sialic acid on basophil histamine release was examined in vitro in allergic patients and normal controls. Enzymatical removal of sialic acid enhanced histamine release induced by allergen and anti-IgE, whereas an increase in membrane sialic acid content by insertion of sialic acid containing gangliosides into the membrane inhibited the mediator release. The reduction in membrane sialic acid content abolished the inhibitory capacity of the calcium channel antagonist nimodipine, whereas the inhibition produced by verapamil and lanthanum was not affected. This difference, together with the previous finding that alterations in membrane sialic acid content is reflected in the cell sensitivity to extracellular calcium, suggest an interaction between membrane sialic acid and the calcium channels involved in basophil histamine release.",

keywords = "Basophils, Calcium, Calcium Channel Blockers, Cell Membrane, Histamine Release, Humans, Ion Channels, Rhinitis, Allergic, Seasonal, Sialic Acids",

author = "C Jensen and S Norn and Skov, {P S} and Dahl, {B T} and Ole Thastrup and A Leon and Svendsen, {U G}",

year = "1987",

language = "English",

volume = "20",

pages = "161--4",

journal = "Agents and Actions",

issn = "0065-4299",

publisher = "Birkhauser Verlag Basel",

number = "3-4",

}

TY - JOUR

T1 - Membrane sialic acid influences basophil histamine release by interfering with calcium dependence

AU - Jensen, C

AU - Norn, S

AU - Skov, P S

AU - Dahl, B T

AU - Thastrup, Ole

AU - Leon, A

AU - Svendsen, U G

PY - 1987

Y1 - 1987

N2 - The influence of the cell membrane content of sialic acid on basophil histamine release was examined in vitro in allergic patients and normal controls. Enzymatical removal of sialic acid enhanced histamine release induced by allergen and anti-IgE, whereas an increase in membrane sialic acid content by insertion of sialic acid containing gangliosides into the membrane inhibited the mediator release. The reduction in membrane sialic acid content abolished the inhibitory capacity of the calcium channel antagonist nimodipine, whereas the inhibition produced by verapamil and lanthanum was not affected. This difference, together with the previous finding that alterations in membrane sialic acid content is reflected in the cell sensitivity to extracellular calcium, suggest an interaction between membrane sialic acid and the calcium channels involved in basophil histamine release.

AB - The influence of the cell membrane content of sialic acid on basophil histamine release was examined in vitro in allergic patients and normal controls. Enzymatical removal of sialic acid enhanced histamine release induced by allergen and anti-IgE, whereas an increase in membrane sialic acid content by insertion of sialic acid containing gangliosides into the membrane inhibited the mediator release. The reduction in membrane sialic acid content abolished the inhibitory capacity of the calcium channel antagonist nimodipine, whereas the inhibition produced by verapamil and lanthanum was not affected. This difference, together with the previous finding that alterations in membrane sialic acid content is reflected in the cell sensitivity to extracellular calcium, suggest an interaction between membrane sialic acid and the calcium channels involved in basophil histamine release.

KW - Basophils

KW - Calcium

KW - Calcium Channel Blockers

KW - Cell Membrane

KW - Histamine Release

KW - Humans

KW - Ion Channels

KW - Rhinitis, Allergic, Seasonal

KW - Sialic Acids

M3 - Journal article

C2 - 2440260

SN - 0065-4299

VL - 20

SP - 161

EP - 164

JO - Agents and Actions

JF - Agents and Actions

IS - 3-4

ER -

Membrane sialic acid influences basophil histamine release by interfering with calcium dependence

Abstract

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