@article{0fed77e074c211dbbee902004c4f4f50,
title = "Mechanisms of hyperpolarization in regenerated mature motor axons in cat",
abstract = "We found persistent abnormalities in the recovery of membrane excitability in long-term regenerated motor nerve fibres in the cat as indicated in the companion paper. These abnormalities could partly be explained by membrane hyperpolarization. To further investigate this possibility, we compared the changes in excitability in control nerves and long-term regenerated cat nerves (3-5 years after tibial nerve crush) during manoeuvres known to alter axonal membrane Na(+)-K(+) pump function: polarization, cooling to 20 degrees C, reperfusion after 10 min ischaemia, and up to 60 s of repetitive stimulation at 200 Hz. The abnormalities in excitability of regenerated nerves were reduced by depolarization and cooling and increased by hyperpolarization and during postischaemia. Moreover, the time course of recovery of excitability from repetitive stimulation and ischaemia was prolonged in regenerated nerves. Our data are consistent with an increased demand for electrogenic Na(+)-K(+) pumping in regenerated nerves leading to membrane hyperpolarization. Such persistent hyperpolarization may influence the ability of the axon to compensate for changes in membrane potential following normal repetitive activity.",
author = "Mihai Moldovan and Christian Krarup",
note = "Keywords: Animals; Axons; Cats; Electric Stimulation; Membrane Potentials; Motor Neurons; Nerve Regeneration; Neural Conduction",
year = "2004",
doi = "10.1113/jphysiol.2004.069443",
language = "English",
volume = "560",
pages = "807--819",
journal = "Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "Pt 3",
}