Mechanisms behind functional avidity maturation in T cells

Marina Rode von Essen; Martin Kongsbak; Carsten Geisler

doi:10.1155/2012/163453

Mechanisms behind functional avidity maturation in T cells

Marina Rode von Essen, Martin Kongsbak, Carsten Geisler

LUKKET: Institut for Immunologi og Mikrobiologi

28 Citationer (Scopus)

Abstract

During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (nave) T cells in a process called functional avidity maturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells.

Originalsprog	Engelsk
Artikelnummer	163453
Tidsskrift	Clinical & Developmental Immunology
Vol/bind	2012
Antal sider	8
ISSN	1740-2522
DOI	https://doi.org/10.1155/2012/163453
Status	Udgivet - jan. 2012

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10.1155/2012/163453

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title = "Mechanisms behind functional avidity maturation in T cells",

abstract = "During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (nave) T cells in a process called functional avidity maturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells.",

keywords = "Animals, Cell Differentiation, Cellular Microenvironment, Cytokines, Humans, Immunologic Memory, Lymphocyte Activation, Receptor Cross-Talk, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocyte Subsets, T-Lymphocytes",

author = "{von Essen}, {Marina Rode} and Martin Kongsbak and Carsten Geisler",

year = "2012",

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doi = "10.1155/2012/163453",

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AU - Kongsbak, Martin

AU - Geisler, Carsten

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N2 - During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (nave) T cells in a process called functional avidity maturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells.

AB - During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (nave) T cells in a process called functional avidity maturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells.

KW - Animals

KW - Cell Differentiation

KW - Cellular Microenvironment

KW - Cytokines

KW - Humans

KW - Immunologic Memory

KW - Lymphocyte Activation

KW - Receptor Cross-Talk

KW - Receptors, Antigen, T-Cell

KW - Signal Transduction

KW - T-Lymphocyte Subsets

KW - T-Lymphocytes

U2 - 10.1155/2012/163453

DO - 10.1155/2012/163453

M3 - Journal article

C2 - 22611418

SN - 2314-8861

VL - 2012

JO - Journal of Immunology Research

JF - Journal of Immunology Research

M1 - 163453

ER -

Mechanisms behind functional avidity maturation in T cells

Abstract

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