@article{c8ded8b0a60111df928f000ea68e967b,
title = "Measurement of brain perfusion, blood volume, and blood-brain barrier permeability, using dynamic contrast-enhanced T(1)-weighted MRI at 3 tesla",
abstract = "Assessment of vascular properties is essential to diagnosis and follow-up and basic understanding of pathogenesis in brain tumors. In this study, a procedure is presented that allows concurrent estimation of cerebral perfusion, blood volume, and blood-brain permeability from dynamic T(1)-weighted imaging of a bolus of a paramagnetic contrast agent passing through the brain. The methods are applied in patients with brain tumors and in healthy subjects. Perfusion was estimated by model-free deconvolution using Tikhonov's method (gray matter/white matter/tumor: 72 +/- 16/30 +/- 8/56 +/- 45 mL/100 g/min); blood volume (6 +/- 2/4 +/- 1/7 +/- 6 mL/100 g) and permeability (0.9 +/- 0.4/0.8 +/- 0.3/3 +/- 5 mL/100 g/min) were estimated by using Patlak's method and a two-compartment model. A corroboration of these results was achieved by using model simulation. In addition, it was possible to generate maps on a pixel-by-pixel basis of cerebral perfusion, cerebral blood volume, and blood-brain barrier permeability.",
author = "Larsson, {Henrik B W} and Fr{\'e}d{\'e}ric Courivaud and Egill Rostrup and Hansen, {Adam E} and Larsson, {Henrik B W} and Fr{\'e}d{\'e}ric Courivaud and Egill Rostrup and Hansen, {Adam E}",
note = "Keywords: Adult; Algorithms; Blood Volume; Blood-Brain Barrier; Brain; Brain Neoplasms; Cerebrovascular Circulation; Computer Simulation; Female; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Models, Biological; Perfusion Imaging; Permeability",
year = "2009",
doi = "10.1002/mrm.22136",
language = "English",
volume = "62",
pages = "1270--81",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "JohnWiley & Sons, Inc.",
number = "5",
}