Maternal Urinary Bisphenol A Concentration During Midterm Pregnancy and Children's Blood Pressure at Age 4

TY - JOUR

T1 - Maternal Urinary Bisphenol A Concentration During Midterm Pregnancy and Children's Blood Pressure at Age 4

AU - Bae, Sanghyuk

AU - Lim, Youn-Hee

AU - Lee, Young Ah

AU - Shin, Choong Ho

AU - Oh, Se-Young

AU - Hong, Yun-Chul

N1 - © 2016 American Heart Association, Inc.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Bisphenol A (BPA) has been reported to be associated with adverse health effects, including high blood pressure (BP). BPA is also suspected to cross placenta in pregnancy and might affect children's health. The present study was aimed to evaluate the effect of prenatal exposure to BPA on the BP of the child at the age of 4. We followed up 645 children at the age of 4 who were born from women who participated midterm during their pregnancy in a birth cohort study from August 2008 to July 2011. Because BPA and BP showed nonlinear association, we constructed a piecewise regression model to examine the association between urinary BPA concentration of mother at around 20 weeks of gestation and BP of the child at age 4 and to determine threshold level of BPA for the association. Diastolic BP of the children was positively associated with maternal urinary concentration of BPA above the threshold level measured at around 20 weeks of gestation. For 1 log unit increment of prenatal urinary BPA concentration, diastolic BP was increased by 7.9 mm Hg (SE=2.072; P=0.0001) after adjusting potential confounders. Pulse pressure was decreased by -8.0 mm Hg (SE=2.528; P=0.0015). However, systolic BP was not significantly associated with prenatal BPA concentration. The present study suggests that exposure to BPA during pregnancy is associated with higher diastolic BP of the children above a certain threshold (4.5 μg/g creatinine).

AB - Bisphenol A (BPA) has been reported to be associated with adverse health effects, including high blood pressure (BP). BPA is also suspected to cross placenta in pregnancy and might affect children's health. The present study was aimed to evaluate the effect of prenatal exposure to BPA on the BP of the child at the age of 4. We followed up 645 children at the age of 4 who were born from women who participated midterm during their pregnancy in a birth cohort study from August 2008 to July 2011. Because BPA and BP showed nonlinear association, we constructed a piecewise regression model to examine the association between urinary BPA concentration of mother at around 20 weeks of gestation and BP of the child at age 4 and to determine threshold level of BPA for the association. Diastolic BP of the children was positively associated with maternal urinary concentration of BPA above the threshold level measured at around 20 weeks of gestation. For 1 log unit increment of prenatal urinary BPA concentration, diastolic BP was increased by 7.9 mm Hg (SE=2.072; P=0.0001) after adjusting potential confounders. Pulse pressure was decreased by -8.0 mm Hg (SE=2.528; P=0.0015). However, systolic BP was not significantly associated with prenatal BPA concentration. The present study suggests that exposure to BPA during pregnancy is associated with higher diastolic BP of the children above a certain threshold (4.5 μg/g creatinine).

KW - Adult

KW - Air Pollutants, Occupational/urine

KW - Benzhydryl Compounds/urine

KW - Blood Pressure/physiology

KW - Blood Pressure Determination

KW - Child, Preschool

KW - Diastole

KW - Female

KW - Follow-Up Studies

KW - Gestational Age

KW - Humans

KW - Incidence

KW - Male

KW - Phenols/urine

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects/epidemiology

KW - Republic of Korea/epidemiology

KW - Retrospective Studies

KW - Time Factors

U2 - 10.1161/hypertensionaha.116.08281

DO - 10.1161/hypertensionaha.116.08281

M3 - Journal article

C2 - 27920131

SN - 0194-911X

VL - 69

SP - 367

EP - 374

JO - Hypertension

JF - Hypertension

IS - 2

ER -