Maternal serum retinol and β-carotene concentrations and neonatal bone mineralization: results from the Southampton Women’s Survey cohort

Mina N Händel; Rebecca J. Moon; Philip Titcombe; Bo Abrahamsen; Berit Heitmann; Calder Philip; Elaine M Dennison; Sian M. Robinson; Keith M Godfrey; Hazel Inskip; Cyrus Cooper; Nicholas C Harvey

doi:10.3945/ajcn.116.130146

Maternal serum retinol and β-carotene concentrations and neonatal bone mineralization: results from the Southampton Women’s Survey cohort

Mina N Händel, Rebecca J. Moon, Philip Titcombe, Bo Abrahamsen, Berit Heitmann, Calder Philip, Elaine M Dennison, Sian M. Robinson, Keith M Godfrey, Hazel Inskip, Cyrus Cooper, Nicholas C Harvey

13 Citationer (Scopus)

Abstract

Background: Studies in older adults and animals have suggested contrasting relations between bone health and different vitamin A compounds. To our knowledge, the associations between maternal vitamin A status and offspring bone development have not previously been elucidated. Objective: We examined the associations between maternal serum retinol and β-carotene concentrations during late pregnancy and offspring bone mineralization assessed at birth with the use of dual-energy X-ray absorptiometry. Design: In the Southampton Women's Survey mother-offspring birth cohort, maternal health, lifestyle, and diet were assessed prepregnancy and at 11 and 34 wk of gestation. In late pregnancy, maternal serum retinol and β-carotene concentrations were measured. Offspring total body bone mineral density (BMD), bone mineral content (BMC), and bone area (BA) were measured within 2 wk after birth. Results: In total, 520 and 446 mother-offspring pairs had measurements of maternal serum retinol and b-carotene, respectively. Higher maternal serum retinol in late pregnancy was associated with lower offspring total body BMC (β = 20.10 SD/SD; 95% CI: 20.19, 20.02; P = 0.020) and BA (β = 20.12 SD/SD; 95% CI: 20.20, 20.03; P = 0.009) but not BMD. Conversely, higher maternal serum b-carotene concentrations in late pregnancy were associated with greater total body BMC (β = 0.12 SD/SD; 95% CI: 0.02, 0.21; P = 0.016) and BA (β = 0.12 SD/SD; 95% CI: 0.03, 0.22; P = 0.010) but not BMD. Conclusions: Maternal serum retinol and β-carotene concentrations had differing associations with offspring bone size and growth at birth: retinol was negatively associated with these measurements, whereas β-carotene was positively associated. These findings highlight the need for further investigation of the effects of maternal retinol and carotenoid status on offspring bone development.

Originalsprog	Engelsk
Tidsskrift	The American Journal of Clinical Nutrition
Vol/bind	104
Udgave nummer	4
Sider (fra-til)	1183-1188
Antal sider	6
ISSN	0002-9165
DOI	https://doi.org/10.3945/ajcn.116.130146
Status	Udgivet - 1 okt. 2016

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10.3945/ajcn.116.130146Licens: CC BY

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Händel, M. N., Moon, R. J., Titcombe, P., Abrahamsen, B., Heitmann, B., Philip, C., Dennison, E. M., Robinson, S. M., Godfrey, K. M., Inskip, H., Cooper, C., & Harvey, N. C. (2016). Maternal serum retinol and β-carotene concentrations and neonatal bone mineralization: results from the Southampton Women’s Survey cohort. The American Journal of Clinical Nutrition, 104(4), 1183-1188. https://doi.org/10.3945/ajcn.116.130146

Maternal serum retinol and β-carotene concentrations and neonatal bone mineralization : results from the Southampton Women’s Survey cohort. / Händel, Mina N; Moon, Rebecca J.; Titcombe, Philip et al.

I: The American Journal of Clinical Nutrition, Bind 104, Nr. 4, 01.10.2016, s. 1183-1188.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Händel, MN, Moon, RJ, Titcombe, P, Abrahamsen, B, Heitmann, B, Philip, C, Dennison, EM, Robinson, SM, Godfrey, KM, Inskip, H, Cooper, C & Harvey, NC 2016, 'Maternal serum retinol and β-carotene concentrations and neonatal bone mineralization: results from the Southampton Women’s Survey cohort', The American Journal of Clinical Nutrition, bind 104, nr. 4, s. 1183-1188. https://doi.org/10.3945/ajcn.116.130146

@article{c3601d8266964fdd91481f6c86c124fa,

title = "Maternal serum retinol and β-carotene concentrations and neonatal bone mineralization: results from the Southampton Women{\textquoteright}s Survey cohort",

abstract = "Background: Studies in older adults and animals have suggested contrasting relations between bone health and different vitamin A compounds. To our knowledge, the associations between maternal vitamin A status and offspring bone development have not previously been elucidated. Objective: We examined the associations between maternal serum retinol and β-carotene concentrations during late pregnancy and offspring bone mineralization assessed at birth with the use of dual-energy X-ray absorptiometry. Design: In the Southampton Women's Survey mother-offspring birth cohort, maternal health, lifestyle, and diet were assessed prepregnancy and at 11 and 34 wk of gestation. In late pregnancy, maternal serum retinol and β-carotene concentrations were measured. Offspring total body bone mineral density (BMD), bone mineral content (BMC), and bone area (BA) were measured within 2 wk after birth. Results: In total, 520 and 446 mother-offspring pairs had measurements of maternal serum retinol and b-carotene, respectively. Higher maternal serum retinol in late pregnancy was associated with lower offspring total body BMC (β = 20.10 SD/SD; 95% CI: 20.19, 20.02; P = 0.020) and BA (β = 20.12 SD/SD; 95% CI: 20.20, 20.03; P = 0.009) but not BMD. Conversely, higher maternal serum b-carotene concentrations in late pregnancy were associated with greater total body BMC (β = 0.12 SD/SD; 95% CI: 0.02, 0.21; P = 0.016) and BA (β = 0.12 SD/SD; 95% CI: 0.03, 0.22; P = 0.010) but not BMD. Conclusions: Maternal serum retinol and β-carotene concentrations had differing associations with offspring bone size and growth at birth: retinol was negatively associated with these measurements, whereas β-carotene was positively associated. These findings highlight the need for further investigation of the effects of maternal retinol and carotenoid status on offspring bone development.",

author = "H{\"a}ndel, {Mina N} and Moon, {Rebecca J.} and Philip Titcombe and Bo Abrahamsen and Berit Heitmann and Calder Philip and Dennison, {Elaine M} and Robinson, {Sian M.} and Godfrey, {Keith M} and Hazel Inskip and Cyrus Cooper and Harvey, {Nicholas C}",

year = "2016",

month = oct,

day = "1",

doi = "10.3945/ajcn.116.130146",

language = "English",

volume = "104",

pages = "1183--1188",

journal = "American Journal of Clinical Nutrition",

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publisher = "American Society for Nutrition",

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TY - JOUR

T1 - Maternal serum retinol and β-carotene concentrations and neonatal bone mineralization

T2 - results from the Southampton Women’s Survey cohort

AU - Händel, Mina N

AU - Moon, Rebecca J.

AU - Titcombe, Philip

AU - Abrahamsen, Bo

AU - Heitmann, Berit

AU - Philip, Calder

AU - Dennison, Elaine M

AU - Robinson, Sian M.

AU - Godfrey, Keith M

AU - Inskip, Hazel

AU - Cooper, Cyrus

AU - Harvey, Nicholas C

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Background: Studies in older adults and animals have suggested contrasting relations between bone health and different vitamin A compounds. To our knowledge, the associations between maternal vitamin A status and offspring bone development have not previously been elucidated. Objective: We examined the associations between maternal serum retinol and β-carotene concentrations during late pregnancy and offspring bone mineralization assessed at birth with the use of dual-energy X-ray absorptiometry. Design: In the Southampton Women's Survey mother-offspring birth cohort, maternal health, lifestyle, and diet were assessed prepregnancy and at 11 and 34 wk of gestation. In late pregnancy, maternal serum retinol and β-carotene concentrations were measured. Offspring total body bone mineral density (BMD), bone mineral content (BMC), and bone area (BA) were measured within 2 wk after birth. Results: In total, 520 and 446 mother-offspring pairs had measurements of maternal serum retinol and b-carotene, respectively. Higher maternal serum retinol in late pregnancy was associated with lower offspring total body BMC (β = 20.10 SD/SD; 95% CI: 20.19, 20.02; P = 0.020) and BA (β = 20.12 SD/SD; 95% CI: 20.20, 20.03; P = 0.009) but not BMD. Conversely, higher maternal serum b-carotene concentrations in late pregnancy were associated with greater total body BMC (β = 0.12 SD/SD; 95% CI: 0.02, 0.21; P = 0.016) and BA (β = 0.12 SD/SD; 95% CI: 0.03, 0.22; P = 0.010) but not BMD. Conclusions: Maternal serum retinol and β-carotene concentrations had differing associations with offspring bone size and growth at birth: retinol was negatively associated with these measurements, whereas β-carotene was positively associated. These findings highlight the need for further investigation of the effects of maternal retinol and carotenoid status on offspring bone development.

AB - Background: Studies in older adults and animals have suggested contrasting relations between bone health and different vitamin A compounds. To our knowledge, the associations between maternal vitamin A status and offspring bone development have not previously been elucidated. Objective: We examined the associations between maternal serum retinol and β-carotene concentrations during late pregnancy and offspring bone mineralization assessed at birth with the use of dual-energy X-ray absorptiometry. Design: In the Southampton Women's Survey mother-offspring birth cohort, maternal health, lifestyle, and diet were assessed prepregnancy and at 11 and 34 wk of gestation. In late pregnancy, maternal serum retinol and β-carotene concentrations were measured. Offspring total body bone mineral density (BMD), bone mineral content (BMC), and bone area (BA) were measured within 2 wk after birth. Results: In total, 520 and 446 mother-offspring pairs had measurements of maternal serum retinol and b-carotene, respectively. Higher maternal serum retinol in late pregnancy was associated with lower offspring total body BMC (β = 20.10 SD/SD; 95% CI: 20.19, 20.02; P = 0.020) and BA (β = 20.12 SD/SD; 95% CI: 20.20, 20.03; P = 0.009) but not BMD. Conversely, higher maternal serum b-carotene concentrations in late pregnancy were associated with greater total body BMC (β = 0.12 SD/SD; 95% CI: 0.02, 0.21; P = 0.016) and BA (β = 0.12 SD/SD; 95% CI: 0.03, 0.22; P = 0.010) but not BMD. Conclusions: Maternal serum retinol and β-carotene concentrations had differing associations with offspring bone size and growth at birth: retinol was negatively associated with these measurements, whereas β-carotene was positively associated. These findings highlight the need for further investigation of the effects of maternal retinol and carotenoid status on offspring bone development.

U2 - 10.3945/ajcn.116.130146

DO - 10.3945/ajcn.116.130146

M3 - Journal article

C2 - 27629051

SN - 0002-9165

VL - 104

SP - 1183

EP - 1188

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 4

ER -

Maternal serum retinol and β-carotene concentrations and neonatal bone mineralization: results from the Southampton Women’s Survey cohort

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