Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific

Holger W Unger; Jordan E Cates; Julie Gutman; Valerie Briand; Nadine Fievet; Innocent Valea; Halidou Tinto; Umberto d'Alessandro; Sarah H Landis; Seth Adu-Afarwuah; Kathryn G Dewey; Feiko Ter Kuile; Stephanie Dellicour; Peter Ouma; Laurence Slutsker; Dianne J Terlouw; Simon Kariuki; John Ayisi; Bernard Nahlen; Meghna Desai; Mwayi Madanitsa; Linda Kalilani-Phiri; Per Ashorn; Kenneth Maleta; Ivo Mueller; Danielle Stanisic; Christentze Schmiegelow; John Lusingu; Daniel Westreich; Anna Maria van Eijk; Steven Meshnick; Stephen Rogerson

doi:10.1136/bmjopen-2016-012697

Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific

Holger W Unger, Jordan E Cates, Julie Gutman, Valerie Briand, Nadine Fievet, Innocent Valea, Halidou Tinto, Umberto d'Alessandro, Sarah H Landis, Seth Adu-Afarwuah, Kathryn G Dewey, Feiko Ter Kuile, Stephanie Dellicour, Peter Ouma, Laurence Slutsker, Dianne J Terlouw, Simon Kariuki, John Ayisi, Bernard Nahlen, Meghna DesaiMwayi Madanitsa, Linda Kalilani-Phiri, Per Ashorn, Kenneth Maleta, Ivo Mueller, Danielle Stanisic, Christentze Schmiegelow, John Lusingu, Daniel Westreich, Anna Maria van Eijk, Steven Meshnick, Stephen Rogerson

3 Citationer (Scopus)

71 Downloads (Pure)

Abstract

Purpose The Maternal Malaria and Malnutrition (M3) initiative has pooled together 13 studies with the hope of improving understanding of malaria-nutrition interactions during pregnancy and to foster collaboration between nutritionists and malariologists. Participants Data were pooled on 14â €..635 singleton, live birth pregnancies from women who had participated in 1 of 13 pregnancy studies. The 13 studies cover 8 countries in Africa and Papua New Guinea in the Western Pacific conducted from 1996 to 2015. Findings to date Data are available at the time of antenatal enrolment of women into their respective parent study and at delivery. The data set comprises essential data such as malaria infection status, anthropometric assessments of maternal nutritional status, presence of anaemia and birth weight, as well as additional variables such gestational age at delivery for a subset of women. Participating studies are described in detail with regard to setting and primary outcome measures, and summarised data are available from each contributing cohort. Future plans This pooled birth cohort is the largest pregnancy data set to date to permit a more definite evaluation of the impact of plausible interactions between poor nutritional status and malaria infection in pregnant women on fetal growth and gestational length. Given the current comparative lack of large pregnancy cohorts in malaria-endemic settings, compilation of suitable pregnancy cohorts is likely to provide adequate statistical power to assess malaria-nutrition interactions, and could point towards settings where such interactions are most relevant. The M3 cohort may thus help to identify pregnant women at high risk of adverse outcomes who may benefit from tailored intensive antenatal care including nutritional supplements and alternative or intensified malaria prevention regimens, and the settings in which these interventions would be most effective.

Originalsprog	Engelsk
Artikelnummer	e012697
Tidsskrift	B M J Open
Vol/bind	6
Udgave nummer	12
Antal sider	11
ISSN	2044-6055
DOI	https://doi.org/10.1136/bmjopen-2016-012697
Status	Udgivet - 1 dec. 2016

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1136/bmjopen-2016-012697Licens: CC BY

Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western PacificForlagets udgivne version, 962 KBLicens: CC BY

Citationsformater

Unger, H. W., Cates, J. E., Gutman, J., Briand, V., Fievet, N., Valea, I., Tinto, H., d'Alessandro, U., Landis, S. H., Adu-Afarwuah, S., Dewey, K. G., Ter Kuile, F., Dellicour, S., Ouma, P., Slutsker, L., Terlouw, D. J., Kariuki, S., Ayisi, J., Nahlen, B., ... Rogerson, S. (2016). Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific. B M J Open, 6(12), [e012697]. https://doi.org/10.1136/bmjopen-2016-012697

Unger, HW, Cates, JE, Gutman, J, Briand, V, Fievet, N, Valea, I, Tinto, H, d'Alessandro, U, Landis, SH, Adu-Afarwuah, S, Dewey, KG, Ter Kuile, F, Dellicour, S, Ouma, P, Slutsker, L, Terlouw, DJ, Kariuki, S, Ayisi, J, Nahlen, B, Desai, M, Madanitsa, M, Kalilani-Phiri, L, Ashorn, P, Maleta, K, Mueller, I, Stanisic, D, Schmiegelow, C, Lusingu, J, Westreich, D, van Eijk, AM, Meshnick, S & Rogerson, S 2016, 'Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific', B M J Open, bind 6, nr. 12, e012697. https://doi.org/10.1136/bmjopen-2016-012697

@article{a6fddff4fd8d4d0fa2111951450ac455,

title = "Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific",

abstract = "Purpose The Maternal Malaria and Malnutrition (M3) initiative has pooled together 13 studies with the hope of improving understanding of malaria-nutrition interactions during pregnancy and to foster collaboration between nutritionists and malariologists. Participants Data were pooled on 14{\^a} €..635 singleton, live birth pregnancies from women who had participated in 1 of 13 pregnancy studies. The 13 studies cover 8 countries in Africa and Papua New Guinea in the Western Pacific conducted from 1996 to 2015. Findings to date Data are available at the time of antenatal enrolment of women into their respective parent study and at delivery. The data set comprises essential data such as malaria infection status, anthropometric assessments of maternal nutritional status, presence of anaemia and birth weight, as well as additional variables such gestational age at delivery for a subset of women. Participating studies are described in detail with regard to setting and primary outcome measures, and summarised data are available from each contributing cohort. Future plans This pooled birth cohort is the largest pregnancy data set to date to permit a more definite evaluation of the impact of plausible interactions between poor nutritional status and malaria infection in pregnant women on fetal growth and gestational length. Given the current comparative lack of large pregnancy cohorts in malaria-endemic settings, compilation of suitable pregnancy cohorts is likely to provide adequate statistical power to assess malaria-nutrition interactions, and could point towards settings where such interactions are most relevant. The M3 cohort may thus help to identify pregnant women at high risk of adverse outcomes who may benefit from tailored intensive antenatal care including nutritional supplements and alternative or intensified malaria prevention regimens, and the settings in which these interventions would be most effective.",

author = "Unger, {Holger W} and Cates, {Jordan E} and Julie Gutman and Valerie Briand and Nadine Fievet and Innocent Valea and Halidou Tinto and Umberto d'Alessandro and Landis, {Sarah H} and Seth Adu-Afarwuah and Dewey, {Kathryn G} and {Ter Kuile}, Feiko and Stephanie Dellicour and Peter Ouma and Laurence Slutsker and Terlouw, {Dianne J} and Simon Kariuki and John Ayisi and Bernard Nahlen and Meghna Desai and Mwayi Madanitsa and Linda Kalilani-Phiri and Per Ashorn and Kenneth Maleta and Ivo Mueller and Danielle Stanisic and Christentze Schmiegelow and John Lusingu and Daniel Westreich and {van Eijk}, {Anna Maria} and Steven Meshnick and Stephen Rogerson",

note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.",

year = "2016",

month = dec,

day = "1",

doi = "10.1136/bmjopen-2016-012697",

language = "English",

volume = "6",

journal = "BMJ Open",

issn = "2044-6055",

publisher = "BMJ Publishing Group",

number = "12",

}

TY - JOUR

T1 - Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific

AU - Unger, Holger W

AU - Cates, Jordan E

AU - Gutman, Julie

AU - Briand, Valerie

AU - Fievet, Nadine

AU - Valea, Innocent

AU - Tinto, Halidou

AU - d'Alessandro, Umberto

AU - Landis, Sarah H

AU - Adu-Afarwuah, Seth

AU - Dewey, Kathryn G

AU - Ter Kuile, Feiko

AU - Dellicour, Stephanie

AU - Ouma, Peter

AU - Slutsker, Laurence

AU - Terlouw, Dianne J

AU - Kariuki, Simon

AU - Ayisi, John

AU - Nahlen, Bernard

AU - Desai, Meghna

AU - Madanitsa, Mwayi

AU - Kalilani-Phiri, Linda

AU - Ashorn, Per

AU - Maleta, Kenneth

AU - Mueller, Ivo

AU - Stanisic, Danielle

AU - Schmiegelow, Christentze

AU - Lusingu, John

AU - Westreich, Daniel

AU - van Eijk, Anna Maria

AU - Meshnick, Steven

AU - Rogerson, Stephen

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Purpose The Maternal Malaria and Malnutrition (M3) initiative has pooled together 13 studies with the hope of improving understanding of malaria-nutrition interactions during pregnancy and to foster collaboration between nutritionists and malariologists. Participants Data were pooled on 14â €..635 singleton, live birth pregnancies from women who had participated in 1 of 13 pregnancy studies. The 13 studies cover 8 countries in Africa and Papua New Guinea in the Western Pacific conducted from 1996 to 2015. Findings to date Data are available at the time of antenatal enrolment of women into their respective parent study and at delivery. The data set comprises essential data such as malaria infection status, anthropometric assessments of maternal nutritional status, presence of anaemia and birth weight, as well as additional variables such gestational age at delivery for a subset of women. Participating studies are described in detail with regard to setting and primary outcome measures, and summarised data are available from each contributing cohort. Future plans This pooled birth cohort is the largest pregnancy data set to date to permit a more definite evaluation of the impact of plausible interactions between poor nutritional status and malaria infection in pregnant women on fetal growth and gestational length. Given the current comparative lack of large pregnancy cohorts in malaria-endemic settings, compilation of suitable pregnancy cohorts is likely to provide adequate statistical power to assess malaria-nutrition interactions, and could point towards settings where such interactions are most relevant. The M3 cohort may thus help to identify pregnant women at high risk of adverse outcomes who may benefit from tailored intensive antenatal care including nutritional supplements and alternative or intensified malaria prevention regimens, and the settings in which these interventions would be most effective.

AB - Purpose The Maternal Malaria and Malnutrition (M3) initiative has pooled together 13 studies with the hope of improving understanding of malaria-nutrition interactions during pregnancy and to foster collaboration between nutritionists and malariologists. Participants Data were pooled on 14â €..635 singleton, live birth pregnancies from women who had participated in 1 of 13 pregnancy studies. The 13 studies cover 8 countries in Africa and Papua New Guinea in the Western Pacific conducted from 1996 to 2015. Findings to date Data are available at the time of antenatal enrolment of women into their respective parent study and at delivery. The data set comprises essential data such as malaria infection status, anthropometric assessments of maternal nutritional status, presence of anaemia and birth weight, as well as additional variables such gestational age at delivery for a subset of women. Participating studies are described in detail with regard to setting and primary outcome measures, and summarised data are available from each contributing cohort. Future plans This pooled birth cohort is the largest pregnancy data set to date to permit a more definite evaluation of the impact of plausible interactions between poor nutritional status and malaria infection in pregnant women on fetal growth and gestational length. Given the current comparative lack of large pregnancy cohorts in malaria-endemic settings, compilation of suitable pregnancy cohorts is likely to provide adequate statistical power to assess malaria-nutrition interactions, and could point towards settings where such interactions are most relevant. The M3 cohort may thus help to identify pregnant women at high risk of adverse outcomes who may benefit from tailored intensive antenatal care including nutritional supplements and alternative or intensified malaria prevention regimens, and the settings in which these interventions would be most effective.

U2 - 10.1136/bmjopen-2016-012697

DO - 10.1136/bmjopen-2016-012697

M3 - Journal article

C2 - 28003287

SN - 2044-6055

VL - 6

JO - BMJ Open

JF - BMJ Open

IS - 12

M1 - e012697

ER -

Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater