Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring

TY - JOUR

T1 - Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring

AU - Søegaard, Signe Holst

AU - Rostgaard, Klaus

AU - Kamper-Jørgensen, Mads

AU - Schmiegelow, Kjeld

AU - Hjalgrim, Henrik

PY - 2018/1/1

Y1 - 2018/1/1

N2 - BACKGROUND: Maternal diabetes may be linked to childhood acute lymphoblastic leukaemia (ALL) in the offspring.METHODS: We assessed the association between maternal pregestational or gestational diabetes and offspring risk of childhood ALL in a register-based study, including all singletons born in Denmark during 1996-2015 (n=1 187 482).RESULTS: Adjusted hazard ratios of childhood ALL were 2.91 (95% confidence interval (CI): 1.30-6.51) for maternal pregestational diabetes and 1.75 (95% CI: 1.02-2.98) for maternal gestational diabetes. Paternal diabetes did not alter offspring ALL risk, and we found no association between offspring ALL and later maternal risk of diabetes.CONCLUSIONS: Regardless that absolute ALL risk among offspring of women with diabetes remains low, our findings suggest that characteristics of the diabetic intrauterine environment promote ALL development. This offers a setting for future research into the biological mechanisms underlying childhood ALL.

AB - BACKGROUND: Maternal diabetes may be linked to childhood acute lymphoblastic leukaemia (ALL) in the offspring.METHODS: We assessed the association between maternal pregestational or gestational diabetes and offspring risk of childhood ALL in a register-based study, including all singletons born in Denmark during 1996-2015 (n=1 187 482).RESULTS: Adjusted hazard ratios of childhood ALL were 2.91 (95% confidence interval (CI): 1.30-6.51) for maternal pregestational diabetes and 1.75 (95% CI: 1.02-2.98) for maternal gestational diabetes. Paternal diabetes did not alter offspring ALL risk, and we found no association between offspring ALL and later maternal risk of diabetes.CONCLUSIONS: Regardless that absolute ALL risk among offspring of women with diabetes remains low, our findings suggest that characteristics of the diabetic intrauterine environment promote ALL development. This offers a setting for future research into the biological mechanisms underlying childhood ALL.

U2 - 10.1038/bjc.2017.351

DO - 10.1038/bjc.2017.351

M3 - Journal article

C2 - 28972964

SN - 0007-0920

VL - 118

SP - 117

EP - 120

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 1

ER -