Mass-spectrometric exploration of proteome structure and function

TY - JOUR

T1 - Mass-spectrometric exploration of proteome structure and function

AU - Aebersold, Ruedi

AU - Mann, Matthias

N1 - AR2016

PY - 2016/9/14

Y1 - 2016/9/14

N2 - Numerous biological processes are concurrently and coordinately active in every living cell. Each of them encompasses synthetic, catalytic and regulatory functions that are, almost always, carried out by proteins organized further into higher-order structures and networks. For decades, the structures and functions of selected proteins have been studied using biochemical and biophysical methods. However, the properties and behaviour of the proteome as an integrated system have largely remained elusive. Powerful mass-spectrometry-based technologies now provide unprecedented insights into the composition, structure, function and control of the proteome, shedding light on complex biological processes and phenotypes.

AB - Numerous biological processes are concurrently and coordinately active in every living cell. Each of them encompasses synthetic, catalytic and regulatory functions that are, almost always, carried out by proteins organized further into higher-order structures and networks. For decades, the structures and functions of selected proteins have been studied using biochemical and biophysical methods. However, the properties and behaviour of the proteome as an integrated system have largely remained elusive. Powerful mass-spectrometry-based technologies now provide unprecedented insights into the composition, structure, function and control of the proteome, shedding light on complex biological processes and phenotypes.

KW - Journal Article

U2 - 10.1038/nature19949

DO - 10.1038/nature19949

M3 - Journal article

C2 - 27629641

SN - 0028-0836

VL - 537

SP - 347

EP - 355

JO - Nature

JF - Nature

IS - 7620

ER -