Mapuche herbal medicine inhibits blood platelet aggregation

TY - JOUR

T1 - Mapuche herbal medicine inhibits blood platelet aggregation

AU - Falkenberg, Susan Skanderup

AU - Tarnow, Inge

AU - Guzman, Alfonso

AU - Mølgaard, Per

AU - Simonsen, Henrik Toft

N1 - Article ID 647620

PY - 2012

Y1 - 2012

N2 - 12 plant species traditionally used by the Mapuche people in Chile to treat wounds and inflammations have been evaluated for their direct blood platelet inhibition. Seven of the 12 tested plant species showed platelet inhibitory effect in sheep blood, and four of these were also able to inhibit the ADP- (5.0 M) and collagen- (2.0 g/mL) induced aggregations in human blood. These four species in respective extracts (in brackets) were Blechnum chilense (MeOH), Luma apiculata (H2O), Amomyrtus luma (DCM:MeOH 1:1) and Cestrum parqui (DCM:MeOH 1:1). The platelet aggregating inhibitory effects of A. luma (DCM:MeOH 1:1), and L. apiculata (H2O) were substantial and confirmed by inhibition of platelet surface activation markers.

AB - 12 plant species traditionally used by the Mapuche people in Chile to treat wounds and inflammations have been evaluated for their direct blood platelet inhibition. Seven of the 12 tested plant species showed platelet inhibitory effect in sheep blood, and four of these were also able to inhibit the ADP- (5.0 M) and collagen- (2.0 g/mL) induced aggregations in human blood. These four species in respective extracts (in brackets) were Blechnum chilense (MeOH), Luma apiculata (H2O), Amomyrtus luma (DCM:MeOH 1:1) and Cestrum parqui (DCM:MeOH 1:1). The platelet aggregating inhibitory effects of A. luma (DCM:MeOH 1:1), and L. apiculata (H2O) were substantial and confirmed by inhibition of platelet surface activation markers.

U2 - 10.1155/2012/647620

DO - 10.1155/2012/647620

M3 - Journal article

C2 - 22028732

SN - 1741-427X

JO - Evidence - Based Complementary and Alternative Medicine

JF - Evidence - Based Complementary and Alternative Medicine

ER -