MAP kinases in inflammatory bowel disease

Mehmet Coskun; Jørgen Olsen; Jakob Benedict Seidelin; Ole Haagen Nielsen

doi:10.1016/j.cca.2010.12.020

MAP kinases in inflammatory bowel disease

Mehmet Coskun, Jørgen Olsen, Jakob Benedict Seidelin, Ole Haagen Nielsen

101 Citationer (Scopus)

Abstract

The mammalian family of mitogen-activated protein kinases (MAPKs) is activated by diverse extracellular and intracellular stimuli, and thereby they play an essential role in connecting cell-surface receptors to changes in transcriptional programs. The MAPK signaling pathways regulate a wide range of cellular activities and have been implicated in the pathogenesis of several diseases, including inflammatory bowel disease (IBD). This review summarizes recent findings on the regulatory mechanism of MAPK signaling pathways, focusing on nuclear targets and their role in IBD. Finally, it summarizes how these signaling pathways have been exploited for the development of therapeutics and discuss the current knowledge of potential MAPK inhibitors and their anti-inflammatory effects in clinical trials related to IBD.

Originalsprog	Engelsk
Tidsskrift	Clinica Chimica Acta
Vol/bind	412
Udgave nummer	7-8
Sider (fra-til)	513-20
Antal sider	8
ISSN	0009-8981
DOI	https://doi.org/10.1016/j.cca.2010.12.020
Status	Udgivet - 18 mar. 2011

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10.1016/j.cca.2010.12.020

Citationsformater

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title = "MAP kinases in inflammatory bowel disease",

abstract = "The mammalian family of mitogen-activated protein kinases (MAPKs) is activated by diverse extracellular and intracellular stimuli, and thereby they play an essential role in connecting cell-surface receptors to changes in transcriptional programs. The MAPK signaling pathways regulate a wide range of cellular activities and have been implicated in the pathogenesis of several diseases, including inflammatory bowel disease (IBD). This review summarizes recent findings on the regulatory mechanism of MAPK signaling pathways, focusing on nuclear targets and their role in IBD. Finally, it summarizes how these signaling pathways have been exploited for the development of therapeutics and discuss the current knowledge of potential MAPK inhibitors and their anti-inflammatory effects in clinical trials related to IBD.",

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TY - JOUR

T1 - MAP kinases in inflammatory bowel disease

AU - Coskun, Mehmet

AU - Olsen, Jørgen

AU - Seidelin, Jakob Benedict

AU - Nielsen, Ole Haagen

PY - 2011/3/18

Y1 - 2011/3/18

N2 - The mammalian family of mitogen-activated protein kinases (MAPKs) is activated by diverse extracellular and intracellular stimuli, and thereby they play an essential role in connecting cell-surface receptors to changes in transcriptional programs. The MAPK signaling pathways regulate a wide range of cellular activities and have been implicated in the pathogenesis of several diseases, including inflammatory bowel disease (IBD). This review summarizes recent findings on the regulatory mechanism of MAPK signaling pathways, focusing on nuclear targets and their role in IBD. Finally, it summarizes how these signaling pathways have been exploited for the development of therapeutics and discuss the current knowledge of potential MAPK inhibitors and their anti-inflammatory effects in clinical trials related to IBD.

AB - The mammalian family of mitogen-activated protein kinases (MAPKs) is activated by diverse extracellular and intracellular stimuli, and thereby they play an essential role in connecting cell-surface receptors to changes in transcriptional programs. The MAPK signaling pathways regulate a wide range of cellular activities and have been implicated in the pathogenesis of several diseases, including inflammatory bowel disease (IBD). This review summarizes recent findings on the regulatory mechanism of MAPK signaling pathways, focusing on nuclear targets and their role in IBD. Finally, it summarizes how these signaling pathways have been exploited for the development of therapeutics and discuss the current knowledge of potential MAPK inhibitors and their anti-inflammatory effects in clinical trials related to IBD.

U2 - 10.1016/j.cca.2010.12.020

DO - 10.1016/j.cca.2010.12.020

M3 - Journal article

C2 - 21185271

SN - 0009-8981

VL - 412

SP - 513

EP - 520

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 7-8

ER -

MAP kinases in inflammatory bowel disease

Abstract

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