Mannan-binding lectin (MBL) in two chicken breeds and the correlation with experimental Pasteurella multocida infection

TY - JOUR

T1 - Mannan-binding lectin (MBL) in two chicken breeds and the correlation with experimental Pasteurella multocida infection

AU - Schou, Torben Wilde

AU - Permin, Anders

AU - Christensen, Jens Peter

AU - Cu, H.P.

AU - Juul-Madsen, Helle Risdahl

PY - 2010/5

Y1 - 2010/5

N2 - The present study is the first demonstration of an association of the genetic serum Mannan-binding lectin (MBL) concentration with bacterial infections in chickens. The genetic serum MBL concentration was determined in two chicken breeds, and the association with the specific Pasteurella multocida humoral immune response during an experimental infection was examined. Furthermore, we examined the association of the genetic serum MBL concentration with systemic infection. The chickens with systemic infection had a statistically significant lower mean serum MBL concentration than the rest of the chickens, suggesting that MBL plays an important role against P. multocida. A statistically significant negative correlation was found between the specific antibody response and the genetic serum MBL concentration for both breeds. This indicates that MBL in chickens is capable of acting as the first line of defence against P. multocida by diminishing the infection before the adaptive immune response takes over.

AB - The present study is the first demonstration of an association of the genetic serum Mannan-binding lectin (MBL) concentration with bacterial infections in chickens. The genetic serum MBL concentration was determined in two chicken breeds, and the association with the specific Pasteurella multocida humoral immune response during an experimental infection was examined. Furthermore, we examined the association of the genetic serum MBL concentration with systemic infection. The chickens with systemic infection had a statistically significant lower mean serum MBL concentration than the rest of the chickens, suggesting that MBL plays an important role against P. multocida. A statistically significant negative correlation was found between the specific antibody response and the genetic serum MBL concentration for both breeds. This indicates that MBL in chickens is capable of acting as the first line of defence against P. multocida by diminishing the infection before the adaptive immune response takes over.

KW - Former LIFE faculty

KW - Mannan-binding lectin

KW - MBL

KW - Innate immunity

KW - Humoral immunity

KW - pasteurella multocida

KW - chickens

U2 - 10.1016/j.cimid.2008.08.010

DO - 10.1016/j.cimid.2008.08.010

M3 - Journal article

C2 - 18922580

SN - 0147-9571

VL - 33

SP - 183

EP - 195

JO - Comparative Immunology, Microbiology & Infectious Diseases

JF - Comparative Immunology, Microbiology & Infectious Diseases

IS - 3

ER -