Mandibular advancement device therapy for obstructive sleep apnea: a prospective study on predictors of treatment success

Niels Petri; Ib Jarle Christensen; Palle Svanholt; Liselotte Sonnesen; Gordon Wildschiødtz; Søren Berg

doi:10.1016/j.sleep.2018.09.033

Mandibular advancement device therapy for obstructive sleep apnea: a prospective study on predictors of treatment success

Niels Petri^*, Ib Jarle Christensen, Palle Svanholt, Liselotte Sonnesen, Gordon Wildschiødtz, Søren Berg

^*Corresponding author af dette arbejde

Sektion 02

5 Citationer (Scopus)

Abstract

Objective: To survey potential predictors of success of mandibular advancement device (MAD) therapy in patients with obstructive sleep apnea (OSA), and in particular, to examine anatomical narrowings and sleep-related collapse levels in the upper airway. Methods: This was a prospective study of 62 OSA patients (median apnea–hypopnea index [AHI] of 34), who were treated with a custom-made, monobloc MAD. The upper airway was examined by inspection, nasopharyngoscopy, overnight acoustic reflectometry recording collapses, and cephalometry of soft tissue dimensions (in addition to skeletal parameters). MAD treatment was controlled by polysomnograpy before and after at least five weeks from the beginning of treatment. Independent predictors of actual reduction in AHI and treatment success (reduction in AHI ≥ 50% with residual AHI < 10) were determined, using multivariable linear and logistic regression. Results: Positional OSA (POSA) and nonsupine AHI (adjusted for upper airway narrowness and collapses, together with gender, age, body mass index, neck circumference, and baseline AHI) were the only independent predictors: POSA indicative for success, and nonsupine AHI inversely related to success. Cephalometry was not predictive. Two predictive models were proposed, one based on POSA having a specificity of 70% and sensitivity of 69%, and the other based on nonsupine AHI, generating a receiver operating characteristic (ROC) curve (area under ROC = 0.78). Using the ROC model, specificity could be increased to 80% without lowering sensitivity. Conclusions: Only variables related to sleep position proved to be independent predictors of success with MAD therapy. The results could be explained by the MAD counteracting the mandible from moving backwards when sleeping supine.

Originalsprog	Engelsk
Tidsskrift	Sleep Medicine
Vol/bind	54
Sider (fra-til)	187-194
Antal sider	8
ISSN	1389-9457
DOI	https://doi.org/10.1016/j.sleep.2018.09.033
Status	Udgivet - 2019

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10.1016/j.sleep.2018.09.033

Citationsformater

@article{3b417008e6c5459296f998d5496ee999,

title = "Mandibular advancement device therapy for obstructive sleep apnea: a prospective study on predictors of treatment success",

abstract = "Objective: To survey potential predictors of success of mandibular advancement device (MAD) therapy in patients with obstructive sleep apnea (OSA), and in particular, to examine anatomical narrowings and sleep-related collapse levels in the upper airway. Methods: This was a prospective study of 62 OSA patients (median apnea–hypopnea index [AHI] of 34), who were treated with a custom-made, monobloc MAD. The upper airway was examined by inspection, nasopharyngoscopy, overnight acoustic reflectometry recording collapses, and cephalometry of soft tissue dimensions (in addition to skeletal parameters). MAD treatment was controlled by polysomnograpy before and after at least five weeks from the beginning of treatment. Independent predictors of actual reduction in AHI and treatment success (reduction in AHI ≥ 50% with residual AHI < 10) were determined, using multivariable linear and logistic regression. Results: Positional OSA (POSA) and nonsupine AHI (adjusted for upper airway narrowness and collapses, together with gender, age, body mass index, neck circumference, and baseline AHI) were the only independent predictors: POSA indicative for success, and nonsupine AHI inversely related to success. Cephalometry was not predictive. Two predictive models were proposed, one based on POSA having a specificity of 70% and sensitivity of 69%, and the other based on nonsupine AHI, generating a receiver operating characteristic (ROC) curve (area under ROC = 0.78). Using the ROC model, specificity could be increased to 80% without lowering sensitivity. Conclusions: Only variables related to sleep position proved to be independent predictors of success with MAD therapy. The results could be explained by the MAD counteracting the mandible from moving backwards when sleeping supine.",

keywords = "Acoustic reflectometry, Cephalometry, Mandibular advancement device, Obstructive sleep apnea, Positional sleep apnea, Predictors of outcome",

author = "Niels Petri and Christensen, {Ib Jarle} and Palle Svanholt and Liselotte Sonnesen and Gordon Wildschi{\o}dtz and S{\o}ren Berg",

year = "2019",

doi = "10.1016/j.sleep.2018.09.033",

language = "English",

volume = "54",

pages = "187--194",

journal = "Sleep Medicine",

issn = "1389-9457",

publisher = "Elsevier",

}

TY - JOUR

T1 - Mandibular advancement device therapy for obstructive sleep apnea

T2 - a prospective study on predictors of treatment success

AU - Petri, Niels

AU - Christensen, Ib Jarle

AU - Svanholt, Palle

AU - Sonnesen, Liselotte

AU - Wildschiødtz, Gordon

AU - Berg, Søren

PY - 2019

Y1 - 2019

N2 - Objective: To survey potential predictors of success of mandibular advancement device (MAD) therapy in patients with obstructive sleep apnea (OSA), and in particular, to examine anatomical narrowings and sleep-related collapse levels in the upper airway. Methods: This was a prospective study of 62 OSA patients (median apnea–hypopnea index [AHI] of 34), who were treated with a custom-made, monobloc MAD. The upper airway was examined by inspection, nasopharyngoscopy, overnight acoustic reflectometry recording collapses, and cephalometry of soft tissue dimensions (in addition to skeletal parameters). MAD treatment was controlled by polysomnograpy before and after at least five weeks from the beginning of treatment. Independent predictors of actual reduction in AHI and treatment success (reduction in AHI ≥ 50% with residual AHI < 10) were determined, using multivariable linear and logistic regression. Results: Positional OSA (POSA) and nonsupine AHI (adjusted for upper airway narrowness and collapses, together with gender, age, body mass index, neck circumference, and baseline AHI) were the only independent predictors: POSA indicative for success, and nonsupine AHI inversely related to success. Cephalometry was not predictive. Two predictive models were proposed, one based on POSA having a specificity of 70% and sensitivity of 69%, and the other based on nonsupine AHI, generating a receiver operating characteristic (ROC) curve (area under ROC = 0.78). Using the ROC model, specificity could be increased to 80% without lowering sensitivity. Conclusions: Only variables related to sleep position proved to be independent predictors of success with MAD therapy. The results could be explained by the MAD counteracting the mandible from moving backwards when sleeping supine.

AB - Objective: To survey potential predictors of success of mandibular advancement device (MAD) therapy in patients with obstructive sleep apnea (OSA), and in particular, to examine anatomical narrowings and sleep-related collapse levels in the upper airway. Methods: This was a prospective study of 62 OSA patients (median apnea–hypopnea index [AHI] of 34), who were treated with a custom-made, monobloc MAD. The upper airway was examined by inspection, nasopharyngoscopy, overnight acoustic reflectometry recording collapses, and cephalometry of soft tissue dimensions (in addition to skeletal parameters). MAD treatment was controlled by polysomnograpy before and after at least five weeks from the beginning of treatment. Independent predictors of actual reduction in AHI and treatment success (reduction in AHI ≥ 50% with residual AHI < 10) were determined, using multivariable linear and logistic regression. Results: Positional OSA (POSA) and nonsupine AHI (adjusted for upper airway narrowness and collapses, together with gender, age, body mass index, neck circumference, and baseline AHI) were the only independent predictors: POSA indicative for success, and nonsupine AHI inversely related to success. Cephalometry was not predictive. Two predictive models were proposed, one based on POSA having a specificity of 70% and sensitivity of 69%, and the other based on nonsupine AHI, generating a receiver operating characteristic (ROC) curve (area under ROC = 0.78). Using the ROC model, specificity could be increased to 80% without lowering sensitivity. Conclusions: Only variables related to sleep position proved to be independent predictors of success with MAD therapy. The results could be explained by the MAD counteracting the mandible from moving backwards when sleeping supine.

KW - Acoustic reflectometry

KW - Cephalometry

KW - Mandibular advancement device

KW - Obstructive sleep apnea

KW - Positional sleep apnea

KW - Predictors of outcome

U2 - 10.1016/j.sleep.2018.09.033

DO - 10.1016/j.sleep.2018.09.033

M3 - Journal article

C2 - 30580193

AN - SCOPUS:85058714073

SN - 1389-9457

VL - 54

SP - 187

EP - 194

JO - Sleep Medicine

JF - Sleep Medicine

ER -

Mandibular advancement device therapy for obstructive sleep apnea: a prospective study on predictors of treatment success

Abstract

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