TY - JOUR
T1 - Mammary gland stem cells
T2 - current status and future challenges
AU - Fridriksdottir, Agla J R
AU - Petersen, Ole W
AU - Rønnov-Jessen, Lone
PY - 2011
Y1 - 2011
N2 - Distinct subsets of cells, including with cell-like properties, have been proposed to exist in normal human breast epithelium and carcinomas. The cellular origins epithelial cells contributing to gland development, tissue homeostasis and cancer are, however, still poorly understood. The mouse is a widely used model mammary gland development, both directly by studying the mouse mammary epithelial cells themselves and indirectly, studying development, morphogenesis, differentiation and carcinogenesis xenotransplanted human epithelium in vivo. While early studies, human or mouse epithelium was implanted as fragments into the mouse gland, more recent technical progress has allowed the self-renewal capacity and differentiation potential of distinct cell populations even individual cells to be interrogated. Here, we review and discuss similarities and differences between mouse and human gland development with particular emphasis on the identity and localization stem cells, and the influence the surrounding microenvironment. It is concluded that while recent advances in the field have contributed immense insight how the normal mammary gland develops and maintained, significant discrepancies exist the mouse and human gland which should taken into consideration current and future models of mammary stem cell biology.
AB - Distinct subsets of cells, including with cell-like properties, have been proposed to exist in normal human breast epithelium and carcinomas. The cellular origins epithelial cells contributing to gland development, tissue homeostasis and cancer are, however, still poorly understood. The mouse is a widely used model mammary gland development, both directly by studying the mouse mammary epithelial cells themselves and indirectly, studying development, morphogenesis, differentiation and carcinogenesis xenotransplanted human epithelium in vivo. While early studies, human or mouse epithelium was implanted as fragments into the mouse gland, more recent technical progress has allowed the self-renewal capacity and differentiation potential of distinct cell populations even individual cells to be interrogated. Here, we review and discuss similarities and differences between mouse and human gland development with particular emphasis on the identity and localization stem cells, and the influence the surrounding microenvironment. It is concluded that while recent advances in the field have contributed immense insight how the normal mammary gland develops and maintained, significant discrepancies exist the mouse and human gland which should taken into consideration current and future models of mammary stem cell biology.
KW - Animals
KW - Breast
KW - Breast Neoplasms
KW - Cell Differentiation
KW - Cell Lineage
KW - Female
KW - Humans
KW - Mammary Glands, Animal
KW - Mice
KW - Neoplastic Stem Cells
KW - Signal Transduction
KW - Stem Cell Niche
KW - Stem Cell Transplantation
KW - Stem Cells
KW - Transplantation, Heterologous
KW - Tumor Microenvironment
U2 - 10.1387/ijdb.113373af
DO - 10.1387/ijdb.113373af
M3 - Journal article
C2 - 22161829
SN - 0214-6282
VL - 55
SP - 719
EP - 729
JO - International Journal of Developmental Biology
JF - International Journal of Developmental Biology
IS - 7-9
ER -
