TY - JOUR
T1 - Mammalian heme peroxidases
T2 - from molecular mechanisms to health implications
AU - Davies, Michael Jonathan
AU - Hawkins, Clare Louise
AU - Pattison, David I
AU - Rees, Martin D
PY - 2008/7
Y1 - 2008/7
N2 - A marked increase in interest has occurred over the last few years in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase, and lactoperoxidase, may play in both disease prevention and human pathologies. This increased interest has been sparked by developments in our understanding of polymorphisms that control the levels of these enzymes, a greater understanding of the basic chemistry and biochemistry of the oxidants formed by these species, the development of specific biomarkers that can be used in vivo to detect damage induced by these oxidants, the detection of active forms of these peroxidases at most, if not all, sites of inflammation, and a correlation between the levels of these enzymes and a number of major human pathologies. This article reviews recent developments in our understanding of the enzymology, chemistry, biochemistry and biologic roles of mammalian peroxidases and the oxidants that they generate, the potential role of these oxidants in human disease, and the use of the levels of these enzymes in disease prognosis.
AB - A marked increase in interest has occurred over the last few years in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase, and lactoperoxidase, may play in both disease prevention and human pathologies. This increased interest has been sparked by developments in our understanding of polymorphisms that control the levels of these enzymes, a greater understanding of the basic chemistry and biochemistry of the oxidants formed by these species, the development of specific biomarkers that can be used in vivo to detect damage induced by these oxidants, the detection of active forms of these peroxidases at most, if not all, sites of inflammation, and a correlation between the levels of these enzymes and a number of major human pathologies. This article reviews recent developments in our understanding of the enzymology, chemistry, biochemistry and biologic roles of mammalian peroxidases and the oxidants that they generate, the potential role of these oxidants in human disease, and the use of the levels of these enzymes in disease prognosis.
KW - Animals
KW - Eosinophil Peroxidase
KW - Heme
KW - Humans
KW - Inflammation
KW - Lactoperoxidase
KW - Oxidants
KW - Peroxidase
KW - Peroxidases
U2 - 10.1089/ars.2007.1927
DO - 10.1089/ars.2007.1927
M3 - Journal article
C2 - 18331199
SN - 1523-0864
VL - 10
SP - 1199
EP - 1234
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
IS - 7
ER -
