Male reproductive health and environmental xenoestrogens

J Toppari; J C Larsen; Peter Christiansen; Alexander Giwercman; P Grandjean; L J Guillette; B Jégou; T K Jensen; P Jouannet; N Keiding; H Leffers; J A McLachlan; O Meyer; Jørn Müller; E Rajpert-De Meyts; T Scheike; R Sharpe; J Sumpter; N E Skakkebaek

Male reproductive health and environmental xenoestrogens

J Toppari, J C Larsen, Peter Christiansen, Alexander Giwercman, P Grandjean, L J Guillette, B Jégou, T K Jensen, P Jouannet, N Keiding, H Leffers, J A McLachlan, O Meyer, Jørn Müller, E Rajpert-De Meyts, T Scheike, R Sharpe, J Sumpter, N E Skakkebaek

1284 Citationer (Scopus)

Abstract

Male reproductive health has deteriorated in many countries during the last few decades. In the 1990s, declining semen quality has been reported from Belgium, Denmark, France, and Great Britain. The incidence of testicular cancer has increased during the same time incidences of hypospadias and cryptorchidism also appear to be increasing. Similar reproductive problems occur in many wildlife species. There are marked geographic differences in the prevalence of male reproductive disorders. While the reasons for these differences are currently unknown, both clinical and laboratory research suggest that the adverse changes may be inter-related and have a common origin in fetal life or childhood. Exposure of the male fetus to supranormal levels of estrogens, such as diethlylstilbestrol, can result in the above-mentioned reproductive defects. The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active (e.g., antiandrogenic) environmental chemicals during fetal and childhood development. An extensive research program is needed to understand the extent of the problem, its underlying etiology, and the development of a strategy for prevention and intervention.

Originalsprog	Engelsk
Tidsskrift	Environmental Health Perspectives
Vol/bind	104 Suppl 4
Sider (fra-til)	741-803
Antal sider	63
ISSN	0091-6765
Status	Udgivet - 1 aug. 1996

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Citationsformater

Toppari, J., Larsen, J. C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L. J., Jégou, B., Jensen, T. K., Jouannet, P., Keiding, N., Leffers, H., McLachlan, J. A., Meyer, O., Müller, J., Rajpert-De Meyts, E., Scheike, T., Sharpe, R., Sumpter, J., & Skakkebaek, N. E. (1996). Male reproductive health and environmental xenoestrogens. Environmental Health Perspectives, 104 Suppl 4, 741-803.

Toppari, J, Larsen, JC, Christiansen, P, Giwercman, A, Grandjean, P, Guillette, LJ, Jégou, B, Jensen, TK, Jouannet, P, Keiding, N, Leffers, H, McLachlan, JA, Meyer, O, Müller, J, Rajpert-De Meyts, E, Scheike, T, Sharpe, R, Sumpter, J & Skakkebaek, NE 1996, 'Male reproductive health and environmental xenoestrogens', Environmental Health Perspectives, bind 104 Suppl 4, s. 741-803.

@article{261484db791d4f3797a6f31b0e0073fb,

title = "Male reproductive health and environmental xenoestrogens",

abstract = "Male reproductive health has deteriorated in many countries during the last few decades. In the 1990s, declining semen quality has been reported from Belgium, Denmark, France, and Great Britain. The incidence of testicular cancer has increased during the same time incidences of hypospadias and cryptorchidism also appear to be increasing. Similar reproductive problems occur in many wildlife species. There are marked geographic differences in the prevalence of male reproductive disorders. While the reasons for these differences are currently unknown, both clinical and laboratory research suggest that the adverse changes may be inter-related and have a common origin in fetal life or childhood. Exposure of the male fetus to supranormal levels of estrogens, such as diethlylstilbestrol, can result in the above-mentioned reproductive defects. The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active (e.g., antiandrogenic) environmental chemicals during fetal and childhood development. An extensive research program is needed to understand the extent of the problem, its underlying etiology, and the development of a strategy for prevention and intervention.",

author = "J Toppari and Larsen, {J C} and Peter Christiansen and Alexander Giwercman and P Grandjean and Guillette, {L J} and B J{\'e}gou and Jensen, {T K} and P Jouannet and N Keiding and H Leffers and McLachlan, {J A} and O Meyer and J{\o}rn M{\"u}ller and {Rajpert-De Meyts}, E and T Scheike and R Sharpe and J Sumpter and Skakkebaek, {N E}",

year = "1996",

month = aug,

day = "1",

language = "English",

volume = "104 Suppl 4",

pages = "741--803",

journal = "Environmental Health Perspectives",

issn = "0091-6765",

publisher = "National Institute of Environmental Health Sciences",

}

TY - JOUR

T1 - Male reproductive health and environmental xenoestrogens

AU - Toppari, J

AU - Larsen, J C

AU - Christiansen, Peter

AU - Giwercman, Alexander

AU - Grandjean, P

AU - Guillette, L J

AU - Jégou, B

AU - Jensen, T K

AU - Jouannet, P

AU - Keiding, N

AU - Leffers, H

AU - McLachlan, J A

AU - Meyer, O

AU - Müller, Jørn

AU - Rajpert-De Meyts, E

AU - Scheike, T

AU - Sharpe, R

AU - Sumpter, J

AU - Skakkebaek, N E

PY - 1996/8/1

Y1 - 1996/8/1

N2 - Male reproductive health has deteriorated in many countries during the last few decades. In the 1990s, declining semen quality has been reported from Belgium, Denmark, France, and Great Britain. The incidence of testicular cancer has increased during the same time incidences of hypospadias and cryptorchidism also appear to be increasing. Similar reproductive problems occur in many wildlife species. There are marked geographic differences in the prevalence of male reproductive disorders. While the reasons for these differences are currently unknown, both clinical and laboratory research suggest that the adverse changes may be inter-related and have a common origin in fetal life or childhood. Exposure of the male fetus to supranormal levels of estrogens, such as diethlylstilbestrol, can result in the above-mentioned reproductive defects. The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active (e.g., antiandrogenic) environmental chemicals during fetal and childhood development. An extensive research program is needed to understand the extent of the problem, its underlying etiology, and the development of a strategy for prevention and intervention.

AB - Male reproductive health has deteriorated in many countries during the last few decades. In the 1990s, declining semen quality has been reported from Belgium, Denmark, France, and Great Britain. The incidence of testicular cancer has increased during the same time incidences of hypospadias and cryptorchidism also appear to be increasing. Similar reproductive problems occur in many wildlife species. There are marked geographic differences in the prevalence of male reproductive disorders. While the reasons for these differences are currently unknown, both clinical and laboratory research suggest that the adverse changes may be inter-related and have a common origin in fetal life or childhood. Exposure of the male fetus to supranormal levels of estrogens, such as diethlylstilbestrol, can result in the above-mentioned reproductive defects. The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active (e.g., antiandrogenic) environmental chemicals during fetal and childhood development. An extensive research program is needed to understand the extent of the problem, its underlying etiology, and the development of a strategy for prevention and intervention.

M3 - Journal article

SN - 0091-6765

VL - 104 Suppl 4

SP - 741

EP - 803

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

ER -

Male reproductive health and environmental xenoestrogens

Abstract

FN’s Verdensmål

Fingeraftryk

Citationsformater