TY - JOUR
T1 - Male Infertility and Risk of Nonmalignant Chronic Diseases
T2 - A Systematic Review of the Epidemiological Evidence
AU - Glazer, Clara Helene
AU - Bonde, Jens Peter
AU - Eisenberg, Michael L.
AU - Giwercman, Aleksander
AU - Hærvig, Katia Keglberg
AU - Rimborg, Susie
AU - Vassard, Ditte
AU - Pinborg, Anja
AU - Schmidt, Lone
AU - Bräuner, Elvira Vaclavik
PY - 2017/5/1
Y1 - 2017/5/1
N2 - The association between male infertility and increased risk of certain cancers is well studied. Less is known about the long-term risk of nonmalignant diseases in men with decreased fertility. A systemic literature review was performed on the epidemiologic evidence of male infertility as a precursor for increased risk of diabetes, cardiovascular diseases, and all-cause mortality. PubMed and Embase were searched from January 1, 1980, to September 1, 2016, to identify epidemiological studies reporting associations between male infertility and the outcomes of interest. Animal studies, case reports, reviews, studies not providing an accurate reference group, and studies including infertility due to vasectomy or malignancy were excluded. The literature search resulted in 2,485 references among which we identified seven articles fulfilling the eligibility criteria. Of these, four articles were prospective (three on risk of mortality, one on risk of chronic diseases) and three were cross-sectional relating male infertility to the Charlson Comorbidity Index. The current epidemiological evidence is compatible with an association between male infertility and risk of chronic disease and mortality, but the small number of prospective studies and insufficient adjustment of confounders preclude strong statements about male infertility as precursor of these outcomes.
AB - The association between male infertility and increased risk of certain cancers is well studied. Less is known about the long-term risk of nonmalignant diseases in men with decreased fertility. A systemic literature review was performed on the epidemiologic evidence of male infertility as a precursor for increased risk of diabetes, cardiovascular diseases, and all-cause mortality. PubMed and Embase were searched from January 1, 1980, to September 1, 2016, to identify epidemiological studies reporting associations between male infertility and the outcomes of interest. Animal studies, case reports, reviews, studies not providing an accurate reference group, and studies including infertility due to vasectomy or malignancy were excluded. The literature search resulted in 2,485 references among which we identified seven articles fulfilling the eligibility criteria. Of these, four articles were prospective (three on risk of mortality, one on risk of chronic diseases) and three were cross-sectional relating male infertility to the Charlson Comorbidity Index. The current epidemiological evidence is compatible with an association between male infertility and risk of chronic disease and mortality, but the small number of prospective studies and insufficient adjustment of confounders preclude strong statements about male infertility as precursor of these outcomes.
KW - Journal Article
U2 - 10.1055/s-0037-1603568
DO - 10.1055/s-0037-1603568
M3 - Review
C2 - 28658712
SN - 1526-8004
VL - 35
SP - 282
EP - 290
JO - Seminars in Reproductive Medicine
JF - Seminars in Reproductive Medicine
IS - 3
ER -
