@article{d746e7c01a4811df8ed1000ea68e967b,
title = "Maintaining the immunological balance in parasitic infections: a role for TGF-{\ss}?",
abstract = "Transforming growth factor beta (TGF-beta) is an important regulator of inflammation, being proinflammatory at low concentrations and anti-inflammatory at high concentrations. As such, TGF-beta might be important in maintaining the balance between control and clearance of infectious organisms on the one hand and prevention of immune-mediated pathology on the other. In this article, Fakhereldin Omer, J{\o}rgen Kurtzhals and Eleanor Riley review the immunoregulatory properties of TGF-beta in the context of parasitic infections. Data from murine malaria infections suggest that TGF-beta modifies the severity of the disease, and a number of potential protective mechanisms are discussed. Evidence is accumulating that TGF-beta is important for the regulation of other host-parasite interactions and that parasites might directly influence TGF-beta-dependent pathways via the synthesis of TGF-beta or TGF-beta-receptor homologues.",
author = "Omer, {F M} and Kurtzhals, {J A} and Riley, {E M}",
note = "Keywords: Animals; Chagas Disease; Genetic Variation; Host-Parasite Interactions; Humans; Leishmaniasis; Malaria; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Plasmodium falciparum; Schistosoma mansoni; Schistosomiasis mansoni; Transforming Growth Factor beta; Trypanosoma cruzi",
year = "2000",
language = "English",
volume = "16",
pages = "18--23",
journal = "Trends in Parasitology",
issn = "1471-4922",
publisher = "Elsevier Ltd. * Trends Journals",
number = "1",
}
