Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health

Sune Dandanell Jørgensen; Camilla Skovborg; Charlotte Boslev Præst; Kasper Bøgh Kristensen; Malene Glerup Nielsen; Sofie Lionett; Sofie Drevsholt Jørgensen; Andreas Vigelsø Hansen; Flemming Dela; Jørn Wulff Helge

doi:10.1016/j.orcp.2016.09.009

Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health

Sune Dandanell Jørgensen, Camilla Skovborg, Charlotte Boslev Præst, Kasper Bøgh Kristensen, Malene Glerup Nielsen, Sofie Lionett, Sofie Drevsholt Jørgensen, Andreas Vigelsø Hansen, Flemming Dela, Jørn Wulff Helge

10 Citationer (Scopus)

Abstract

Objective Intensive lifestyle interventions (ILI) are criticised for ineffective obesity treatment because weight loss over time is modest and thus of limited clinical relevance. However, a subgroup (5–30%) maintains a clinical weight loss >10%, but it is not clear if cardiometabolic health follows this pattern. The aim was to study the effect of different magnitudes of weight loss maintenance after ILI on cardiometabolic health. Methods Eighty out of 2420 former participants (age: 36 ± 1, BMI: 38 ± 1, (means ±SE)) in an 11–12-week ILI were recruited into 3 groups; clinical weight loss maintenance (>10% weight loss), moderate maintenance (1–10%), and weight regain based on weight loss at follow-up (5.3 ± 0.4 years). Weight loss during the ILI was achieved by increased physical activity and hypo-caloric diet. Dual X-ray Absorptiometry, blood sample, skeletal muscle biopsy and VO_2max test were used to determine cardiometabolic health at follow-up. Results At follow-up, the clinical weight loss maintenance group scored better in the following variables compared to the other groups: BMI (31 ± 1, 33 ± 2, 43 ± 2 kg/m²), composition (34 ± 2, 40 ± 1, 49 ± 1% fat), visceral adipose tissue (0.8 ± 0.2, 1.7 ± 0.5, 2.4 ± 0.4 kg), plasma triglycerides (0.8 ± 0.2, 1.3 ± 0.4, 1.6 ± 0.3 mmol/L), plasma glucose (4.9 ± 0.1, 5.9 ± 0.4, 5.9 ± 0.1 mmol/L), Hb1Ac (5.1 ± 0.0, 5.6 ± 0.2, 5.8 ± 0.2%), protein content in skeletal muscle of GLUT4 (1.5 ± 0.2, 0.9 ± 0.1, 1.0 ± 0.1 AU) and hexokinase II (1.6 ± 0.2, 1.0 ± 0.2, 0.7 ± 0.1 AU), citrate synthase activity (155 ± 6, 130 ± 5, 113 ± 5 μmol/g/min) and VO_2max (49 ± 1, 43 ± 1, 41 ± 1 mL/min/FFM) (p < 0.05). Conclusion Cardiometabolic health is better in participants who have maintained >10% weight loss compared to moderate weight loss and weight regain.

Originalsprog	Engelsk
Tidsskrift	Obesity Research & Clinical Practice
Vol/bind	11
Udgave nummer	4
Sider (fra-til)	489-498
Antal sider	10
ISSN	1871-403X
DOI	https://doi.org/10.1016/j.orcp.2016.09.009
Status	Udgivet - jul. 2017

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10.1016/j.orcp.2016.09.009

Citationsformater

Jørgensen, S. D., Skovborg, C., Præst, C. B., Kristensen, K. B., Nielsen, M. G., Lionett, S., Jørgensen, S. D., Vigelsø Hansen, A., Dela, F., & Helge, J. W. (2017). Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health. Obesity Research & Clinical Practice, 11(4), 489-498. https://doi.org/10.1016/j.orcp.2016.09.009

@article{b324a34cca614033b87486da14d42dbf,

title = "Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health",

abstract = "Objective Intensive lifestyle interventions (ILI) are criticised for ineffective obesity treatment because weight loss over time is modest and thus of limited clinical relevance. However, a subgroup (5–30%) maintains a clinical weight loss >10%, but it is not clear if cardiometabolic health follows this pattern. The aim was to study the effect of different magnitudes of weight loss maintenance after ILI on cardiometabolic health. Methods Eighty out of 2420 former participants (age: 36 ± 1, BMI: 38 ± 1, (means ±SE)) in an 11–12-week ILI were recruited into 3 groups; clinical weight loss maintenance (>10% weight loss), moderate maintenance (1–10%), and weight regain based on weight loss at follow-up (5.3 ± 0.4 years). Weight loss during the ILI was achieved by increased physical activity and hypo-caloric diet. Dual X-ray Absorptiometry, blood sample, skeletal muscle biopsy and VO2max test were used to determine cardiometabolic health at follow-up. Results At follow-up, the clinical weight loss maintenance group scored better in the following variables compared to the other groups: BMI (31 ± 1, 33 ± 2, 43 ± 2 kg/m2), composition (34 ± 2, 40 ± 1, 49 ± 1% fat), visceral adipose tissue (0.8 ± 0.2, 1.7 ± 0.5, 2.4 ± 0.4 kg), plasma triglycerides (0.8 ± 0.2, 1.3 ± 0.4, 1.6 ± 0.3 mmol/L), plasma glucose (4.9 ± 0.1, 5.9 ± 0.4, 5.9 ± 0.1 mmol/L), Hb1Ac (5.1 ± 0.0, 5.6 ± 0.2, 5.8 ± 0.2%), protein content in skeletal muscle of GLUT4 (1.5 ± 0.2, 0.9 ± 0.1, 1.0 ± 0.1 AU) and hexokinase II (1.6 ± 0.2, 1.0 ± 0.2, 0.7 ± 0.1 AU), citrate synthase activity (155 ± 6, 130 ± 5, 113 ± 5 μmol/g/min) and VO2max (49 ± 1, 43 ± 1, 41 ± 1 mL/min/FFM) (p < 0.05). Conclusion Cardiometabolic health is better in participants who have maintained >10% weight loss compared to moderate weight loss and weight regain.",

author = "J{\o}rgensen, {Sune Dandanell} and Camilla Skovborg and Pr{\ae}st, {Charlotte Boslev} and Kristensen, {Kasper B{\o}gh} and Nielsen, {Malene Glerup} and Sofie Lionett and J{\o}rgensen, {Sofie Drevsholt} and {Vigels{\o} Hansen}, Andreas and Flemming Dela and Helge, {J{\o}rn Wulff}",

year = "2017",

month = jul,

doi = "10.1016/j.orcp.2016.09.009",

language = "English",

volume = "11",

pages = "489--498",

journal = "Obesity Research & Clinical Practice",

issn = "1871-403X",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health

AU - Jørgensen, Sune Dandanell

AU - Skovborg, Camilla

AU - Præst, Charlotte Boslev

AU - Kristensen, Kasper Bøgh

AU - Nielsen, Malene Glerup

AU - Lionett, Sofie

AU - Jørgensen, Sofie Drevsholt

AU - Vigelsø Hansen, Andreas

AU - Dela, Flemming

AU - Helge, Jørn Wulff

PY - 2017/7

Y1 - 2017/7

N2 - Objective Intensive lifestyle interventions (ILI) are criticised for ineffective obesity treatment because weight loss over time is modest and thus of limited clinical relevance. However, a subgroup (5–30%) maintains a clinical weight loss >10%, but it is not clear if cardiometabolic health follows this pattern. The aim was to study the effect of different magnitudes of weight loss maintenance after ILI on cardiometabolic health. Methods Eighty out of 2420 former participants (age: 36 ± 1, BMI: 38 ± 1, (means ±SE)) in an 11–12-week ILI were recruited into 3 groups; clinical weight loss maintenance (>10% weight loss), moderate maintenance (1–10%), and weight regain based on weight loss at follow-up (5.3 ± 0.4 years). Weight loss during the ILI was achieved by increased physical activity and hypo-caloric diet. Dual X-ray Absorptiometry, blood sample, skeletal muscle biopsy and VO2max test were used to determine cardiometabolic health at follow-up. Results At follow-up, the clinical weight loss maintenance group scored better in the following variables compared to the other groups: BMI (31 ± 1, 33 ± 2, 43 ± 2 kg/m2), composition (34 ± 2, 40 ± 1, 49 ± 1% fat), visceral adipose tissue (0.8 ± 0.2, 1.7 ± 0.5, 2.4 ± 0.4 kg), plasma triglycerides (0.8 ± 0.2, 1.3 ± 0.4, 1.6 ± 0.3 mmol/L), plasma glucose (4.9 ± 0.1, 5.9 ± 0.4, 5.9 ± 0.1 mmol/L), Hb1Ac (5.1 ± 0.0, 5.6 ± 0.2, 5.8 ± 0.2%), protein content in skeletal muscle of GLUT4 (1.5 ± 0.2, 0.9 ± 0.1, 1.0 ± 0.1 AU) and hexokinase II (1.6 ± 0.2, 1.0 ± 0.2, 0.7 ± 0.1 AU), citrate synthase activity (155 ± 6, 130 ± 5, 113 ± 5 μmol/g/min) and VO2max (49 ± 1, 43 ± 1, 41 ± 1 mL/min/FFM) (p < 0.05). Conclusion Cardiometabolic health is better in participants who have maintained >10% weight loss compared to moderate weight loss and weight regain.

AB - Objective Intensive lifestyle interventions (ILI) are criticised for ineffective obesity treatment because weight loss over time is modest and thus of limited clinical relevance. However, a subgroup (5–30%) maintains a clinical weight loss >10%, but it is not clear if cardiometabolic health follows this pattern. The aim was to study the effect of different magnitudes of weight loss maintenance after ILI on cardiometabolic health. Methods Eighty out of 2420 former participants (age: 36 ± 1, BMI: 38 ± 1, (means ±SE)) in an 11–12-week ILI were recruited into 3 groups; clinical weight loss maintenance (>10% weight loss), moderate maintenance (1–10%), and weight regain based on weight loss at follow-up (5.3 ± 0.4 years). Weight loss during the ILI was achieved by increased physical activity and hypo-caloric diet. Dual X-ray Absorptiometry, blood sample, skeletal muscle biopsy and VO2max test were used to determine cardiometabolic health at follow-up. Results At follow-up, the clinical weight loss maintenance group scored better in the following variables compared to the other groups: BMI (31 ± 1, 33 ± 2, 43 ± 2 kg/m2), composition (34 ± 2, 40 ± 1, 49 ± 1% fat), visceral adipose tissue (0.8 ± 0.2, 1.7 ± 0.5, 2.4 ± 0.4 kg), plasma triglycerides (0.8 ± 0.2, 1.3 ± 0.4, 1.6 ± 0.3 mmol/L), plasma glucose (4.9 ± 0.1, 5.9 ± 0.4, 5.9 ± 0.1 mmol/L), Hb1Ac (5.1 ± 0.0, 5.6 ± 0.2, 5.8 ± 0.2%), protein content in skeletal muscle of GLUT4 (1.5 ± 0.2, 0.9 ± 0.1, 1.0 ± 0.1 AU) and hexokinase II (1.6 ± 0.2, 1.0 ± 0.2, 0.7 ± 0.1 AU), citrate synthase activity (155 ± 6, 130 ± 5, 113 ± 5 μmol/g/min) and VO2max (49 ± 1, 43 ± 1, 41 ± 1 mL/min/FFM) (p < 0.05). Conclusion Cardiometabolic health is better in participants who have maintained >10% weight loss compared to moderate weight loss and weight regain.

U2 - 10.1016/j.orcp.2016.09.009

DO - 10.1016/j.orcp.2016.09.009

M3 - Journal article

C2 - 27720417

SN - 1871-403X

VL - 11

SP - 489

EP - 498

JO - Obesity Research & Clinical Practice

JF - Obesity Research & Clinical Practice

IS - 4

ER -

Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health

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