Maintained exercise-enhanced brain executive function related to cerebral lactate metabolism in men

TY - JOUR

T1 - Maintained exercise-enhanced brain executive function related to cerebral lactate metabolism in men

AU - Hashimoto, Takeshi

AU - Tsukamoto, Hayato

AU - Takenaka, Saki

AU - Olesen, Niels D.

AU - Petersen, Lonnie G.

AU - Sørensen, Henrik

AU - Nielsen, Henning B.

AU - Secher, Niels H.

AU - Ogoh, Shigehiko

PY - 2018

Y1 - 2018

N2 - High-intensity interval exercise (HIIE) improves cerebral executive function (EF), but the improvement in EF is attenuated after repeated HIIE, perhaps because of lower lactate availability for the brain. This investigation examined whether improved EF after exercise relates to brain lactate uptake. Fourteen healthy, male subjects performed 2HIIEprotocols separatedby 60min of rest.Blood sampleswere obtained fromthe right internal jugular venous bulb and from the brachial artery to determine arterial-venous differences across the brain for lactate (a-v difflactate), glucose (a-v diffglucose), oxygen (a-v diffoxygen), and brain-derived neurotrophic factor (BDNF; a-v diffBDNF). EF was evaluated by the color-word Stroop task. The first HIIE improved EF for 40 min, whereas the second HIIE improved EF only immediately after exercise. The a-v diffglucose was unchanged, whereas the a-v diffBDNF increased similarly after both HIIEs, and the a-v difflactate increased, but the increase was attenuated after the secondHIIE, compared with the firstHIIE (P < 0.05).The EF after HIIE correlatedwith the a-v difflactate (r2=0.62; P < 0.01). We propose that attenuated improvement in EF after repeated HIIE relates to reduced cerebral lactate metabolism and is, thereby, linked to systemic metabolism as an example of the lactate shuttle mechanism.

AB - High-intensity interval exercise (HIIE) improves cerebral executive function (EF), but the improvement in EF is attenuated after repeated HIIE, perhaps because of lower lactate availability for the brain. This investigation examined whether improved EF after exercise relates to brain lactate uptake. Fourteen healthy, male subjects performed 2HIIEprotocols separatedby 60min of rest.Blood sampleswere obtained fromthe right internal jugular venous bulb and from the brachial artery to determine arterial-venous differences across the brain for lactate (a-v difflactate), glucose (a-v diffglucose), oxygen (a-v diffoxygen), and brain-derived neurotrophic factor (BDNF; a-v diffBDNF). EF was evaluated by the color-word Stroop task. The first HIIE improved EF for 40 min, whereas the second HIIE improved EF only immediately after exercise. The a-v diffglucose was unchanged, whereas the a-v diffBDNF increased similarly after both HIIEs, and the a-v difflactate increased, but the increase was attenuated after the secondHIIE, compared with the firstHIIE (P < 0.05).The EF after HIIE correlatedwith the a-v difflactate (r2=0.62; P < 0.01). We propose that attenuated improvement in EF after repeated HIIE relates to reduced cerebral lactate metabolism and is, thereby, linked to systemic metabolism as an example of the lactate shuttle mechanism.

KW - Brain energy uptake

KW - Brain-derived neurotrophic factor

KW - Cognitive function

KW - Glucose

KW - High-intensity interval exercise

U2 - 10.1096/fj.201700381RR

DO - 10.1096/fj.201700381RR

M3 - Journal article

C2 - 29127193

AN - SCOPUS:85036637181

SN - 0892-6638

VL - 32

SP - 1417

EP - 1427

JO - F A S E B Journal

JF - F A S E B Journal

IS - 3

ER -