Magnetic Resonance Imaging: A New Tool to Optimize the Prediction of Fetal Anemia?

Ditte S. Jørgensen; Niels Vejlstrup; Line Rode; Charlotte K Ekelund; Christopher K Macgowan; Lisa N Jensen; Lone Nikoline Nørgaard; Sharon Portnoy; Mike Seed; Karin Sundberg; Kirsten Søgaard; Julie Lyng Forman; Ann Tabor

doi:10.1159/000494615

Magnetic Resonance Imaging: A New Tool to Optimize the Prediction of Fetal Anemia?

Ditte S. Jørgensen, Niels Vejlstrup, Line Rode, Charlotte K Ekelund, Christopher K Macgowan, Lisa N Jensen, Lone Nikoline Nørgaard, Sharon Portnoy, Mike Seed, Karin Sundberg, Kirsten Søgaard, Julie Lyng Forman, Ann Tabor

2 Citationer (Scopus)

Abstract

Introduction: The false-positive rate in the prediction of fetal anemia is 10-15%. We investigated if a new, noninvasive MRI method used as a supplement to ultrasound could improve the prediction. Methods: Fetuses suspected of anemia and controls were scanned in a 1.5-tesla MRI scanner 1-4 times during pregnancy. Cases were scanned before and after intrauterine blood transfusion with a T1-mapping MRI sequence in a cross-section of the umbilical vein. Results: Inclusion of 8 cases and 11 controls resulted in 10 case scans (2 cases were included twice) and 33 control scans. In controls, the T1 relaxation time was 1,005-1,391 ms; in cases with severe anemia, 1,505-1,595 ms, moderate anemia 1,503-1,525 ms, and no/mild anemia 1,245-1,410 ms. After blood transfusions, values dropped to 1,123-1,288 ms. The mean value in moderate and severe anemic cases was 275 ms higher than in controls (95% CI 210-341 ms, p < 0.0001), and after blood transfusion it was comparable to controls (3 ms, 95% CI -62 to 68 ms, p = 0.934). A 1,450-ms cut-off would have identified all cases in need of blood transfusion with no false-positive cases. Conclusions: Our findings indicate a potential for this new MRI method to improve the prediction of fetal anemia as a supplement to ultrasound.

Originalsprog	Engelsk
Tidsskrift	Fetal Diagnosis and Therapy
Vol/bind	46
Udgave nummer	4
Sider (fra-til)	257-265
Antal sider	9
ISSN	1015-3837
DOI	https://doi.org/10.1159/000494615
Status	Udgivet - 1 okt. 2019

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10.1159/000494615

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title = "Magnetic Resonance Imaging: A New Tool to Optimize the Prediction of Fetal Anemia?",

abstract = "Introduction: The false-positive rate in the prediction of fetal anemia is 10-15%. We investigated if a new, noninvasive MRI method used as a supplement to ultrasound could improve the prediction. Methods: Fetuses suspected of anemia and controls were scanned in a 1.5-tesla MRI scanner 1-4 times during pregnancy. Cases were scanned before and after intrauterine blood transfusion with a T1-mapping MRI sequence in a cross-section of the umbilical vein. Results: Inclusion of 8 cases and 11 controls resulted in 10 case scans (2 cases were included twice) and 33 control scans. In controls, the T1 relaxation time was 1,005-1,391 ms; in cases with severe anemia, 1,505-1,595 ms, moderate anemia 1,503-1,525 ms, and no/mild anemia 1,245-1,410 ms. After blood transfusions, values dropped to 1,123-1,288 ms. The mean value in moderate and severe anemic cases was 275 ms higher than in controls (95% CI 210-341 ms, p < 0.0001), and after blood transfusion it was comparable to controls (3 ms, 95% CI -62 to 68 ms, p = 0.934). A 1,450-ms cut-off would have identified all cases in need of blood transfusion with no false-positive cases. Conclusions: Our findings indicate a potential for this new MRI method to improve the prediction of fetal anemia as a supplement to ultrasound.",

author = "J{\o}rgensen, {Ditte S.} and Niels Vejlstrup and Line Rode and Ekelund, {Charlotte K} and Macgowan, {Christopher K} and Jensen, {Lisa N} and N{\o}rgaard, {Lone Nikoline} and Sharon Portnoy and Mike Seed and Karin Sundberg and Kirsten S{\o}gaard and Forman, {Julie Lyng} and Ann Tabor",

note = "{\textcopyright} 2019 S. Karger AG, Basel.",

year = "2019",

month = oct,

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doi = "10.1159/000494615",

language = "English",

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T1 - Magnetic Resonance Imaging

T2 - A New Tool to Optimize the Prediction of Fetal Anemia?

AU - Jørgensen, Ditte S.

AU - Vejlstrup, Niels

AU - Rode, Line

AU - Ekelund, Charlotte K

AU - Macgowan, Christopher K

AU - Jensen, Lisa N

AU - Nørgaard, Lone Nikoline

AU - Portnoy, Sharon

AU - Seed, Mike

AU - Sundberg, Karin

AU - Søgaard, Kirsten

AU - Forman, Julie Lyng

AU - Tabor, Ann

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Introduction: The false-positive rate in the prediction of fetal anemia is 10-15%. We investigated if a new, noninvasive MRI method used as a supplement to ultrasound could improve the prediction. Methods: Fetuses suspected of anemia and controls were scanned in a 1.5-tesla MRI scanner 1-4 times during pregnancy. Cases were scanned before and after intrauterine blood transfusion with a T1-mapping MRI sequence in a cross-section of the umbilical vein. Results: Inclusion of 8 cases and 11 controls resulted in 10 case scans (2 cases were included twice) and 33 control scans. In controls, the T1 relaxation time was 1,005-1,391 ms; in cases with severe anemia, 1,505-1,595 ms, moderate anemia 1,503-1,525 ms, and no/mild anemia 1,245-1,410 ms. After blood transfusions, values dropped to 1,123-1,288 ms. The mean value in moderate and severe anemic cases was 275 ms higher than in controls (95% CI 210-341 ms, p < 0.0001), and after blood transfusion it was comparable to controls (3 ms, 95% CI -62 to 68 ms, p = 0.934). A 1,450-ms cut-off would have identified all cases in need of blood transfusion with no false-positive cases. Conclusions: Our findings indicate a potential for this new MRI method to improve the prediction of fetal anemia as a supplement to ultrasound.

AB - Introduction: The false-positive rate in the prediction of fetal anemia is 10-15%. We investigated if a new, noninvasive MRI method used as a supplement to ultrasound could improve the prediction. Methods: Fetuses suspected of anemia and controls were scanned in a 1.5-tesla MRI scanner 1-4 times during pregnancy. Cases were scanned before and after intrauterine blood transfusion with a T1-mapping MRI sequence in a cross-section of the umbilical vein. Results: Inclusion of 8 cases and 11 controls resulted in 10 case scans (2 cases were included twice) and 33 control scans. In controls, the T1 relaxation time was 1,005-1,391 ms; in cases with severe anemia, 1,505-1,595 ms, moderate anemia 1,503-1,525 ms, and no/mild anemia 1,245-1,410 ms. After blood transfusions, values dropped to 1,123-1,288 ms. The mean value in moderate and severe anemic cases was 275 ms higher than in controls (95% CI 210-341 ms, p < 0.0001), and after blood transfusion it was comparable to controls (3 ms, 95% CI -62 to 68 ms, p = 0.934). A 1,450-ms cut-off would have identified all cases in need of blood transfusion with no false-positive cases. Conclusions: Our findings indicate a potential for this new MRI method to improve the prediction of fetal anemia as a supplement to ultrasound.

U2 - 10.1159/000494615

DO - 10.1159/000494615

M3 - Journal article

C2 - 30731466

SN - 1015-3837

VL - 46

SP - 257

EP - 265

JO - Fetal Diagnosis and Therapy

JF - Fetal Diagnosis and Therapy

IS - 4

ER -

Magnetic Resonance Imaging: A New Tool to Optimize the Prediction of Fetal Anemia?

Abstract

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