Lysosomal cell death at a glance

TY - JOUR

T1 - Lysosomal cell death at a glance

AU - Aits, Sonja

AU - Jaattela, Marja

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases that can degrade most cellular macromolecules. Lysosomal membrane permeabilization and the consequent leakage of the lysosomal content into the cytosol leads to so-called "lysosomal cell death". This form of cell death is mainly carried out by the lysosomal cathepsin proteases and can have necrotic, apoptotic or apoptosis-like features depending on the extent of the leakage and the cellular context. This article summarizes our current knowledge on lysosomal cell death with an emphasis on the upstream mechanisms that lead to lysosomal membrane permeabilization.

AB - Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases that can degrade most cellular macromolecules. Lysosomal membrane permeabilization and the consequent leakage of the lysosomal content into the cytosol leads to so-called "lysosomal cell death". This form of cell death is mainly carried out by the lysosomal cathepsin proteases and can have necrotic, apoptotic or apoptosis-like features depending on the extent of the leakage and the cellular context. This article summarizes our current knowledge on lysosomal cell death with an emphasis on the upstream mechanisms that lead to lysosomal membrane permeabilization.

U2 - 10.1242/jcs.091181

DO - 10.1242/jcs.091181

M3 - Journal article

C2 - 23720375

SN - 0021-9533

VL - 126

SP - 1905

EP - 1912

JO - Journal of Cell Science

JF - Journal of Cell Science

IS - Pt 9

ER -