Lymphoproliferative responses to Plasmodium falciparum antigens in children with and without the sickle cell trait

TY - JOUR

T1 - Lymphoproliferative responses to Plasmodium falciparum antigens in children with and without the sickle cell trait

AU - Abu-Zeid, Y A

AU - Abdulhadi, N H

AU - Hviid, L

AU - Theander, T G

AU - Saeed, B O

AU - Jepsen, S

AU - Jensen, J B

AU - Bayoumi, R A

N1 - Keywords: Animals; Antigens, Protozoan; Child; Humans; Immunologic Memory; Lymphocyte Activation; Malaria; Phytohemagglutinins; Plasmodium falciparum; Sickle Cell Trait; Tuberculin

PY - 1991

Y1 - 1991

N2 - Blood mononuclear cells (BMNC) were isolated from sickle cell trait (HbAS) healthy donors and normal haemoglobin (HbAA) healthy donors resident in a P. falciparum endemic area of eastern Sudan. Blood samples were collected during the malaria season. BMNC were tested for their proliferative responses to phytohaemagglutinin (PHA), purified protein derivative of tuberculin (PPD) and to soluble P. falciparum antigens (SPAg). Higher responses to SPAg and PPD were observed in the HbAS children compared with the HbAA children, whereas no differences were observed among adults of the two phenotypes. Proliferative responses to PHA were comparable in all individuals tested. The significance of these findings in relation to haemoglobin phenotype, age and the possible immunoregulatory mechanisms operating in HbAS and HbAA children during the malaria season is discussed.

AB - Blood mononuclear cells (BMNC) were isolated from sickle cell trait (HbAS) healthy donors and normal haemoglobin (HbAA) healthy donors resident in a P. falciparum endemic area of eastern Sudan. Blood samples were collected during the malaria season. BMNC were tested for their proliferative responses to phytohaemagglutinin (PHA), purified protein derivative of tuberculin (PPD) and to soluble P. falciparum antigens (SPAg). Higher responses to SPAg and PPD were observed in the HbAS children compared with the HbAA children, whereas no differences were observed among adults of the two phenotypes. Proliferative responses to PHA were comparable in all individuals tested. The significance of these findings in relation to haemoglobin phenotype, age and the possible immunoregulatory mechanisms operating in HbAS and HbAA children during the malaria season is discussed.

M3 - Journal article

C2 - 1866602

SN - 0300-9475

VL - 34

SP - 237

EP - 242

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

IS - 2

ER -