Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy

Talita Honorato; Annemieke Hoek; Anna-Karina Henningsen; Anja Pinborg; Ojvind Lidegaard; Thea Mooij; Floor van Leeuwen; Jolande Land; Henk Groen; Maaike Haadsma; OMEGA project group

doi:10.1016/j.rbmo.2017.08.022

Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy

Talita Honorato, Annemieke Hoek, Anna-Karina Henningsen, Anja Pinborg, Ojvind Lidegaard, Thea Mooij, Floor van Leeuwen, Jolande Land, Henk Groen, Maaike Haadsma, OMEGA project group

Institut for Klinisk Medicin

3 Citationer (Scopus)

Abstract

A low number of antral follicles may result in the selection of suboptimal oocytes that are prone to meiotic errors. The aim of this case-control study was to evaluate women receiving IVF treatment with low oocyte yield (defined as three or fewer oocytes retrieved after ovarian stimulation) who are at an increased risk of a trisomic pregnancy. Data were obtained from Danish and Dutch medical registries between 1983 and 2011. Analyses were carried out in 105 cases and 442 controls matched by age and year of IVF treatment. Cases were women with a trisomic pregnancy (trisomies 13, 18 or 21) resulting from fresh IVF treatment and confirmed by karyotyping. Cases were included regardless of pregnancy outcome. Controls were women with a live born child without a trisomy, resulting from fresh IVF treatment. Low oocyte yield was observed in 6.6% (29/440) of the women, of which 8.4% (7/83) were cases and 6.2% (22/357) controls. Low oocyte yield in IVF treatment was not associated with a higher risk of trisomic pregnancy (OR 1.43, 95% CI 0.64 to 3.19). Stratification for female age, adjustment for history of ovarian surgery, and gonadotrophin-releasing hormone protocol used did not change the results.

Originalsprog	Engelsk
Tidsskrift	Reproductive BioMedicine Online
Vol/bind	35
Udgave nummer	6
Sider (fra-til)	685-692
Antal sider	8
ISSN	1472-6483
DOI	https://doi.org/10.1016/j.rbmo.2017.08.022
Status	Udgivet - dec. 2017

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10.1016/j.rbmo.2017.08.022

http://www.rbmojournal.com/article/S147264831730411X/pdf

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title = "Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy",

abstract = "A low number of antral follicles may result in the selection of suboptimal oocytes that are prone to meiotic errors. The aim of this case-control study was to evaluate women receiving IVF treatment with low oocyte yield (defined as three or fewer oocytes retrieved after ovarian stimulation) who are at an increased risk of a trisomic pregnancy. Data were obtained from Danish and Dutch medical registries between 1983 and 2011. Analyses were carried out in 105 cases and 442 controls matched by age and year of IVF treatment. Cases were women with a trisomic pregnancy (trisomies 13, 18 or 21) resulting from fresh IVF treatment and confirmed by karyotyping. Cases were included regardless of pregnancy outcome. Controls were women with a live born child without a trisomy, resulting from fresh IVF treatment. Low oocyte yield was observed in 6.6% (29/440) of the women, of which 8.4% (7/83) were cases and 6.2% (22/357) controls. Low oocyte yield in IVF treatment was not associated with a higher risk of trisomic pregnancy (OR 1.43, 95% CI 0.64 to 3.19). Stratification for female age, adjustment for history of ovarian surgery, and gonadotrophin-releasing hormone protocol used did not change the results.",

author = "Talita Honorato and Annemieke Hoek and Anna-Karina Henningsen and Anja Pinborg and Ojvind Lidegaard and Thea Mooij and {van Leeuwen}, Floor and Jolande Land and Henk Groen and Maaike Haadsma and {OMEGA project group}",

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AU - Honorato, Talita

AU - Hoek, Annemieke

AU - Henningsen, Anna-Karina

AU - Pinborg, Anja

AU - Lidegaard, Ojvind

AU - Mooij, Thea

AU - van Leeuwen, Floor

AU - Land, Jolande

AU - Groen, Henk

AU - Haadsma, Maaike

AU - OMEGA project group

PY - 2017/12

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N2 - A low number of antral follicles may result in the selection of suboptimal oocytes that are prone to meiotic errors. The aim of this case-control study was to evaluate women receiving IVF treatment with low oocyte yield (defined as three or fewer oocytes retrieved after ovarian stimulation) who are at an increased risk of a trisomic pregnancy. Data were obtained from Danish and Dutch medical registries between 1983 and 2011. Analyses were carried out in 105 cases and 442 controls matched by age and year of IVF treatment. Cases were women with a trisomic pregnancy (trisomies 13, 18 or 21) resulting from fresh IVF treatment and confirmed by karyotyping. Cases were included regardless of pregnancy outcome. Controls were women with a live born child without a trisomy, resulting from fresh IVF treatment. Low oocyte yield was observed in 6.6% (29/440) of the women, of which 8.4% (7/83) were cases and 6.2% (22/357) controls. Low oocyte yield in IVF treatment was not associated with a higher risk of trisomic pregnancy (OR 1.43, 95% CI 0.64 to 3.19). Stratification for female age, adjustment for history of ovarian surgery, and gonadotrophin-releasing hormone protocol used did not change the results.

AB - A low number of antral follicles may result in the selection of suboptimal oocytes that are prone to meiotic errors. The aim of this case-control study was to evaluate women receiving IVF treatment with low oocyte yield (defined as three or fewer oocytes retrieved after ovarian stimulation) who are at an increased risk of a trisomic pregnancy. Data were obtained from Danish and Dutch medical registries between 1983 and 2011. Analyses were carried out in 105 cases and 442 controls matched by age and year of IVF treatment. Cases were women with a trisomic pregnancy (trisomies 13, 18 or 21) resulting from fresh IVF treatment and confirmed by karyotyping. Cases were included regardless of pregnancy outcome. Controls were women with a live born child without a trisomy, resulting from fresh IVF treatment. Low oocyte yield was observed in 6.6% (29/440) of the women, of which 8.4% (7/83) were cases and 6.2% (22/357) controls. Low oocyte yield in IVF treatment was not associated with a higher risk of trisomic pregnancy (OR 1.43, 95% CI 0.64 to 3.19). Stratification for female age, adjustment for history of ovarian surgery, and gonadotrophin-releasing hormone protocol used did not change the results.

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DO - 10.1016/j.rbmo.2017.08.022

M3 - Journal article

C2 - 28942116

SN - 1472-6483

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SP - 685

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JO - Reproductive BioMedicine Online

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Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy

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